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Benign neoplasm of brain stem

MedGen UID:
146353
•Concept ID:
C0686400
•
Neoplastic Process
Synonyms: Benign Brain Stem Neoplasm; benign brain stem neoplasm; Benign Brain Stem Neoplasms; benign brain stem neoplasms; Benign Brain Stem Tumor; benign brain stem tumor; benign brain stem tumour; Benign Brainstem Neoplasm; benign brainstem neoplasm; Benign Brainstem Neoplasms; benign brainstem neoplasms; Benign Brainstem Tumor; benign brainstem tumor; Benign Brainstem Tumors; benign brainstem tumors; benign brainstem tumour; benign brainstem tumours; Benign Neoplasm of Brain Stem; benign neoplasm of brain stem; Benign Neoplasm of Brainstem; benign neoplasm of brainstem; Benign Neoplasm of the Brain Stem; benign neoplasm of the brain stem; Benign Neoplasm of the Brainstem; benign neoplasm of the brainstem; Benign Neoplasms of Brainstem; benign neoplasms of brainstem; Benign Neoplasms of the Brainstem; benign neoplasms of the brainstem; Benign Tumor of Brain Stem; benign tumor of brain stem; Benign Tumor of Brainstem; benign tumor of brainstem; Benign Tumor of the Brain Stem; benign tumor of the brain stem; Benign Tumor of the Brainstem; benign tumor of the brainstem; Benign Tumors of Brainstem; benign tumors of brainstem; Benign Tumors of the Brainstem; benign tumors of the brainstem; benign tumour of brain stem; benign tumour of brainstem; benign tumour of the brain stem; benign tumour of the brainstem; benign tumours of brainstem; benign tumours of the brainstem; brainstem benign neoplasm
SNOMED CT: Benign neoplasm of brain stem (92029009)
 
Monarch Initiative: MONDO:0021507

Definition

A neoplasm that arises from the brain stem and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign neoplasm of brain stem

Professional guidelines

PubMed

Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
Biermann J, Melms JC, Amin AD, Wang Y, Caprio LA, Karz A, Tagore S, Barrera I, Ibarra-Arellano MA, Andreatta M, Fullerton BT, Gretarsson KH, Sahu V, Mangipudy VS, Nguyen TTT, Nair A, Rogava M, Ho P, Koch PD, Banu M, Humala N, Mahajan A, Walsh ZH, Shah SB, Vaccaro DH, Caldwell B, Mu M, Wünnemann F, Chazotte M, Berhe S, Luoma AM, Driver J, Ingham M, Khan SA, Rapisuwon S, Slingluff CL Jr, Eigentler T, Röcken M, Carvajal R, Atkins MB, Davies MA, Agustinus A, Bakhoum SF, Azizi E, Siegelin M, Lu C, Carmona SJ, Hibshoosh H, Ribas A, Canoll P, Bruce JN, Bi WL, Agrawal P, Schapiro D, Hernando E, Macosko EZ, Chen F, Schwartz GK, Izar B
Cell 2022 Jul 7;185(14):2591-2608.e30. doi: 10.1016/j.cell.2022.06.007. PMID: 35803246Free PMC Article
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I
Cells 2021 Mar 11;10(3) doi: 10.3390/cells10030621. PMID: 33799798Free PMC Article

Recent clinical studies

Etiology

Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma.
Li G, Wang D, Zhai Y, Pan C, Zhang J, Wang C, Huang R, Yu M, Li Y, Liu X, Liu Y, Wu F, Zhao Z, Hu H, Shi Z, Kahlert UD, Jiang T, Zhang W
Cell Metab 2024 Aug 6;36(8):1696-1710.e10. doi: 10.1016/j.cmet.2024.07.011. PMID: 39111285
Classification of Brain Tumors by Nanopore Sequencing of Cell-Free DNA from Cerebrospinal Fluid.
Afflerbach AK, Rohrandt C, Brändl B, Sönksen M, Hench J, Frank S, Börnigen D, Alawi M, Mynarek M, Winkler B, Ricklefs F, Synowitz M, Dührsen L, Rutkowski S, Wefers AK, Müller FJ, Schoof M, Schüller U
Clin Chem 2024 Jan 4;70(1):250-260. doi: 10.1093/clinchem/hvad115. PMID: 37624932
Identification of a novel cuproptosis-related gene signature and integrative analyses in patients with lower-grade gliomas.
Bao JH, Lu WC, Duan H, Ye YQ, Li JB, Liao WT, Li YC, Sun YP
Front Immunol 2022;13:933973. Epub 2022 Aug 15 doi: 10.3389/fimmu.2022.933973. PMID: 36045691Free PMC Article
Molecular targeted therapy of glioblastoma.
Le Rhun E, Preusser M, Roth P, Reardon DA, van den Bent M, Wen P, Reifenberger G, Weller M
Cancer Treat Rev 2019 Nov;80:101896. Epub 2019 Sep 11 doi: 10.1016/j.ctrv.2019.101896. PMID: 31541850
Glioma.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790

Diagnosis

Glioma.
Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
Pilocytic Astrocytoma: A Review of General, Clinical, and Molecular Characteristics.
Salles D, Laviola G, Malinverni ACM, Stávale JN
J Child Neurol 2020 Oct;35(12):852-858. Epub 2020 Jul 20 doi: 10.1177/0883073820937225. PMID: 32691644
Brain malignancies: Glioblastoma and brain metastases.
Lah TT, Novak M, Breznik B
Semin Cancer Biol 2020 Feb;60:262-273. Epub 2019 Oct 22 doi: 10.1016/j.semcancer.2019.10.010. PMID: 31654711
A comprehensive profile of recurrent glioblastoma.
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580
Glioblastoma multiforme: Pathogenesis and treatment.
Alifieris C, Trafalis DT
Pharmacol Ther 2015 Aug;152:63-82. Epub 2015 May 2 doi: 10.1016/j.pharmthera.2015.05.005. PMID: 25944528

Therapy

Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I
Cells 2021 Mar 11;10(3) doi: 10.3390/cells10030621. PMID: 33799798Free PMC Article
Tumor Treating Fields in the Management of Patients with Malignant Gliomas.
Ghiaseddin AP, Shin D, Melnick K, Tran DD
Curr Treat Options Oncol 2020 Jul 30;21(9):76. doi: 10.1007/s11864-020-00773-5. PMID: 32734509Free PMC Article
Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma.
Ahir BK, Engelhard HH, Lakka SS
Mol Neurobiol 2020 May;57(5):2461-2478. Epub 2020 Mar 9 doi: 10.1007/s12035-020-01892-8. PMID: 32152825Free PMC Article
Molecular targeted therapy of glioblastoma.
Le Rhun E, Preusser M, Roth P, Reardon DA, van den Bent M, Wen P, Reifenberger G, Weller M
Cancer Treat Rev 2019 Nov;80:101896. Epub 2019 Sep 11 doi: 10.1016/j.ctrv.2019.101896. PMID: 31541850
Glioblastoma multiforme: Pathogenesis and treatment.
Alifieris C, Trafalis DT
Pharmacol Ther 2015 Aug;152:63-82. Epub 2015 May 2 doi: 10.1016/j.pharmthera.2015.05.005. PMID: 25944528

Prognosis

Glioma.
Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma.
Yang E, Wang L, Jin W, Liu X, Wang Q, Wu Y, Tan Y, Wang Y, Cui X, Zhao J, Tong F, Hong B, Xiao M, Liu X, Fang C, Kang C
Theranostics 2022;12(9):4330-4347. Epub 2022 May 16 doi: 10.7150/thno.71763. PMID: 35673568Free PMC Article
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I
Cells 2021 Mar 11;10(3) doi: 10.3390/cells10030621. PMID: 33799798Free PMC Article
Synaptic proximity enables NMDAR signalling to promote brain metastasis.
Zeng Q, Michael IP, Zhang P, Saghafinia S, Knott G, Jiao W, McCabe BD, Galván JA, Robinson HPC, Zlobec I, Ciriello G, Hanahan D
Nature 2019 Sep;573(7775):526-531. Epub 2019 Sep 18 doi: 10.1038/s41586-019-1576-6. PMID: 31534217Free PMC Article
A comprehensive profile of recurrent glioblastoma.
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580

Clinical prediction guides

Identification of a novel cuproptosis-related gene signature and integrative analyses in patients with lower-grade gliomas.
Bao JH, Lu WC, Duan H, Ye YQ, Li JB, Liao WT, Li YC, Sun YP
Front Immunol 2022;13:933973. Epub 2022 Aug 15 doi: 10.3389/fimmu.2022.933973. PMID: 36045691Free PMC Article
Pilocytic Astrocytoma: A Review of General, Clinical, and Molecular Characteristics.
Salles D, Laviola G, Malinverni ACM, Stávale JN
J Child Neurol 2020 Oct;35(12):852-858. Epub 2020 Jul 20 doi: 10.1177/0883073820937225. PMID: 32691644
The Glioma Stem Cell Model in the Era of Single-Cell Genomics.
Suvà ML, Tirosh I
Cancer Cell 2020 May 11;37(5):630-636. doi: 10.1016/j.ccell.2020.04.001. PMID: 32396858
MGMT Status as a Clinical Biomarker in Glioblastoma.
Butler M, Pongor L, Su YT, Xi L, Raffeld M, Quezado M, Trepel J, Aldape K, Pommier Y, Wu J
Trends Cancer 2020 May;6(5):380-391. Epub 2020 Mar 27 doi: 10.1016/j.trecan.2020.02.010. PMID: 32348734Free PMC Article
A comprehensive profile of recurrent glioblastoma.
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580

Recent systematic reviews

Surgical Management of Adult Brainstem Gliomas: A Systematic Review and Meta-Analysis.
Ius T, Lombardi G, Baiano C, Berardinelli J, Romano A, Montemurro N, Cavallo LM, Pasqualetti F, Feletti A
Curr Oncol 2023 Nov 7;30(11):9772-9785. doi: 10.3390/curroncol30110709. PMID: 37999129Free PMC Article
The clinical importance of medulloblastoma extent of resection: a systematic review.
Thompson EM, Bramall A, Herndon JE 2nd, Taylor MD, Ramaswamy V
J Neurooncol 2018 Sep;139(3):523-539. Epub 2018 May 23 doi: 10.1007/s11060-018-2906-5. PMID: 29796724
Overweight, obesity and adiposity in survivors of childhood brain tumours: a systematic review and meta-analysis.
Wang KW, Fleming A, Johnston DL, Zelcer SM, Rassekh SR, Ladhani S, Socha A, Shinuda J, Jaber S, Burrow S, Singh SK, Banfield L, de Souza RJ, Thabane L, Samaan MC
Clin Obes 2018 Feb;8(1):55-67. Epub 2017 Oct 11 doi: 10.1111/cob.12224. PMID: 29024558
Childhood Brain Tumors: a Systematic Review of the Structural Neuroimaging Literature.
Ailion AS, Hortman K, King TZ
Neuropsychol Rev 2017 Sep;27(3):220-244. Epub 2017 Jun 23 doi: 10.1007/s11065-017-9352-6. PMID: 28646252
Natural history of cavernous malformation: Systematic review and meta-analysis of 25 studies.
Taslimi S, Modabbernia A, Amin-Hanjani S, Barker FG 2nd, Macdonald RL
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