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Neoplasm of oropharynx

MedGen UID:
14519
•Concept ID:
C0029295
•
Neoplastic Process
Synonyms: Neoplasm, Oropharyngeal; Neoplasm, Oropharynx; Neoplasms, Oropharyngeal; Neoplasms, Oropharynx; Oropharyngeal Neoplasm; Oropharyngeal Neoplasms; Oropharynx Neoplasm; Oropharynx Neoplasms
SNOMED CT: Neoplasm of oropharynx (126809003); Tumor of oropharynx (126809003)
 
Monarch Initiative: MONDO:0021364

Definition

A benign or malignant neoplasm that affects the oropharynx. [from NCI]

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

Cancer of the Oropharynx and the Association with Human Papillomavirus.
Rettig EM, Sethi RKV
Hematol Oncol Clin North Am 2021 Oct;35(5):913-931. Epub 2021 Jul 7 doi: 10.1016/j.hoc.2021.05.004. PMID: 34244016
Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual.
Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, Loomis AM, Shah JP
CA Cancer J Clin 2017 Mar;67(2):122-137. Epub 2017 Jan 27 doi: 10.3322/caac.21389. PMID: 28128848
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
Epidemiology of cancer from the oral cavity and oropharynx.
Lambert R, Sauvaget C, de Camargo Cancela M, Sankaranarayanan R
Eur J Gastroenterol Hepatol 2011 Aug;23(8):633-41. doi: 10.1097/MEG.0b013e3283484795. PMID: 21654320
Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.
Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Calais G
J Clin Oncol 2004 Jan 1;22(1):69-76. Epub 2003 Dec 2 doi: 10.1200/JCO.2004.08.021. PMID: 14657228

Diagnosis

Cancer of the Oropharynx and the Association with Human Papillomavirus.
Rettig EM, Sethi RKV
Hematol Oncol Clin North Am 2021 Oct;35(5):913-931. Epub 2021 Jul 7 doi: 10.1016/j.hoc.2021.05.004. PMID: 34244016
Human papillomavirus-associated oropharyngeal cancer: review of current evidence and management.
You EL, Henry M, Zeitouni AG
Curr Oncol 2019 Apr;26(2):119-123. Epub 2019 Apr 1 doi: 10.3747/co.26.4819. PMID: 31043814Free PMC Article
Human Papillomavirus and Oropharyngeal Cancer.
Tanaka TI, Alawi F
Dent Clin North Am 2018 Jan;62(1):111-120. Epub 2017 Oct 7 doi: 10.1016/j.cden.2017.08.008. PMID: 29126488
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
Oropharyngeal cancer.
Psyrri A, Prezas L, Burtness B
Clin Adv Hematol Oncol 2008 Aug;6(8):604-12. PMID: 18820604

Therapy

Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.
Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma.
Denis F, Garaud P, Bardet E, Alfonsi M, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Calais G
J Clin Oncol 2004 Jan 1;22(1):69-76. Epub 2003 Dec 2 doi: 10.1200/JCO.2004.08.021. PMID: 14657228
Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer.
Pignon JP, Bourhis J, Domenge C, Designé L
Lancet 2000 Mar 18;355(9208):949-55. PMID: 10768432

Prognosis

Staging of human papilloma virus related cancers of the oropharynx.
Valero C, Shah JP
J Surg Oncol 2021 Nov;124(6):931-934. doi: 10.1002/jso.26584. PMID: 34622962Free PMC Article
Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).
Yom SS, Torres-Saavedra P, Caudell JJ, Waldron JN, Gillison ML, Xia P, Truong MT, Kong C, Jordan R, Subramaniam RM, Yao M, Chung CH, Geiger JL, Chan JW, O'Sullivan B, Blakaj DM, Mell LK, Thorstad WL, Jones CU, Banerjee RN, Lominska C, Le QT
J Clin Oncol 2021 Mar 20;39(9):956-965. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03128. PMID: 33507809Free PMC Article
Oral and oropharyngeal cancer.
Huber MA, Tantiwongkosi B
Med Clin North Am 2014 Nov;98(6):1299-321. Epub 2014 Sep 20 doi: 10.1016/j.mcna.2014.08.005. PMID: 25443678
Robotic assisted reconstruction of the oropharynx.
de Almeida JR, Genden EM
Curr Opin Otolaryngol Head Neck Surg 2012 Aug;20(4):237-45. doi: 10.1097/MOO.0b013e328354c24e. PMID: 22894991
HPV-associated head and neck cancer: a virus-related cancer epidemic.
Marur S, D'Souza G, Westra WH, Forastiere AA
Lancet Oncol 2010 Aug;11(8):781-9. Epub 2010 May 5 doi: 10.1016/S1470-2045(10)70017-6. PMID: 20451455Free PMC Article

Clinical prediction guides

MRI Dynamic Contrast Imaging of Oral Cavity and Oropharyngeal Tumors.
Sideras P, Singh G
Top Magn Reson Imaging 2021 Apr 1;30(2):97-104. doi: 10.1097/RMR.0000000000000283. PMID: 33828061
Radiotherapy in Metastatic Oropharyngeal Cancer.
Nguy S, Oh C, Karp JM, Wu SP, Li Z, Persky MJ, Hu KS, Givi B, Tam MM
Laryngoscope 2021 Jun;131(6):E1847-E1853. Epub 2020 Nov 3 doi: 10.1002/lary.29245. PMID: 33141455
The New Face of Head and Neck Cancer: The HPV Epidemic.
Lewis A, Kang R, Levine A, Maghami E
Oncology (Williston Park) 2015 Sep;29(9):616-26. PMID: 26384796
Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review.
Grimminger CM, Danenberg PV
Eur Arch Otorhinolaryngol 2011 Jan;268(1):5-16. Epub 2010 Sep 9 doi: 10.1007/s00405-010-1369-x. PMID: 20827554
Surgical salvage of the oropharynx after failure of organ-sparing therapy.
Nichols AC, Kneuertz PJ, Deschler DG, Lin DT, Emerick KS, Clark JR, Busse PW, Rocco JW
Head Neck 2011 Apr;33(4):516-24. doi: 10.1002/hed.21480. PMID: 20652974

Recent systematic reviews

Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis.
Fonsêca TC, Jural LA, Marañón-Vásquez GA, Magno MB, Roza ALOC, Ferreira DMTP, Maia LC, Romañach MJ, Agostini M, Abrahão AC
Clin Oral Investig 2023 Dec 30;28(1):62. doi: 10.1007/s00784-023-05425-0. PMID: 38158517
Expert Consensus Statement: Management of Dysphagia in Head and Neck Cancer Patients.
Kuhn MA, Gillespie MB, Ishman SL, Ishii LE, Brody R, Cohen E, Dhar SI, Hutcheson K, Jefferson G, Johnson F, Rameau A, Sher D, Starmer H, Strohl M, Ulmer K, Vaitaitis V, Begum S, Batjargal M, Dhepyasuwan N
Otolaryngol Head Neck Surg 2023 Apr;168(4):571-592. doi: 10.1002/ohn.302. PMID: 36965195
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Parmar A, Macluskey M, Mc Goldrick N, Conway DI, Glenny AM, Clarkson JE, Worthington HV, Chan KK
Cochrane Database Syst Rev 2021 Dec 20;12(12):CD006386. doi: 10.1002/14651858.CD006386.pub4. PMID: 34929047Free PMC Article
Swallowing exercises for head and neck cancer patients: A systematic review and meta-analysis of randomized control trials.
Banda KJ, Chu H, Kao CC, Voss J, Chiu HL, Chang PC, Chen R, Chou KR
Int J Nurs Stud 2021 Feb;114:103827. Epub 2020 Nov 11 doi: 10.1016/j.ijnurstu.2020.103827. PMID: 33352439
Association between physical activity and digestive-system cancer: An updated systematic review and meta-analysis.
Xie F, You Y, Huang J, Guan C, Chen Z, Fang M, Yao F, Han J
J Sport Health Sci 2021 Jan;10(1):4-13. Epub 2020 Sep 30 doi: 10.1016/j.jshs.2020.09.009. PMID: 33010525Free PMC Article

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