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Nevus of Ota

MedGen UID:
14363
•Concept ID:
C0027961
•
Neoplastic Process
Synonyms: Nevus, Ota's; Ota Nevus; Ota's Nevus; Otas Nevus
SNOMED CT: Oculocutaneous melanocytic nevus (254817005); Nevus fusoceruleus ophthalmomaxillaris (254817005); Nevus of Ota (254817005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0009920
Monarch Initiative: MONDO:0016984
Orphanet: ORPHA263425

Definition

A dermal melanocytic hamartoma that presents as bluish hyperpigmentation on the face along the first or second branches of the trigeminal nerve. Nevus of Ota may involve the sclera. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNevus of Ota
Follow this link to review classifications for Nevus of Ota in Orphanet.

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Characteristics and management of Asian skin.
Chan IL, Cohen S, da Cunha MG, Maluf LC
Int J Dermatol 2019 Feb;58(2):131-143. Epub 2018 Jul 24 doi: 10.1111/ijd.14153. PMID: 30039861
Picosecond Laser Treatment for Acquired Bilateral Nevus of Ota-like Macules.
Wong THS
JAMA Dermatol 2018 Oct 1;154(10):1226-1228. doi: 10.1001/jamadermatol.2018.2671. PMID: 30208473

Recent clinical studies

Etiology

Picosecond alexandrite laser treatment of nevus of Ota in children.
Zhao W, Yang Y, Shi H, Guo L, Ding H, Zhen H, Lin T, Ge Y
Lasers Surg Med 2024 Jul;56(5):437-445. Epub 2024 May 6 doi: 10.1002/lsm.23795. PMID: 38711166
High-fluence 1064nm Q-switched Nd:YAG laser treatment for ectopic Mongolian spot.
Shin JO, Roh D, Shin K, Kim HS, Kim BS, Kim MB, Ko HC
J Dermatolog Treat 2023 Dec;34(1):2255057. Epub 2023 Oct 2 doi: 10.1080/09546634.2023.2255057. PMID: 37781886
Changes in melanocytic nevi treated with laser hair removal: A systematic review.
Cices A, Dover JS, Labadie JG
Lasers Surg Med 2023 Sep;55(7):617-624. Epub 2023 Jul 26 doi: 10.1002/lsm.23712. PMID: 37493510
Melanoma in the setting of nevus of Ota: a review for dermatologists.
Williams NM, Gurnani P, Labib A, Nuesi R, Nouri K
Int J Dermatol 2021 May;60(5):523-532. Epub 2020 Aug 17 doi: 10.1111/ijd.15135. PMID: 32808287
Characteristics and management of Asian skin.
Chan IL, Cohen S, da Cunha MG, Maluf LC
Int J Dermatol 2019 Feb;58(2):131-143. Epub 2018 Jul 24 doi: 10.1111/ijd.14153. PMID: 30039861

Diagnosis

Shades of blue: Nevus of Ota in a child.
El Belidi H, Benkirane R, Saoiabi Y, Cherkaoui LO
J Fr Ophtalmol 2024 Jan;47(1):103964. Epub 2023 Oct 10 doi: 10.1016/j.jfo.2023.03.045. PMID: 37827944
Nevus of Ota in 8-year-old male.
Berelli S, Daigavane S
Pan Afr Med J 2023;45:81. Epub 2023 Jun 9 doi: 10.11604/pamj.2023.45.81.40463. PMID: 37663639Free PMC Article
Nevus of Ota.
Patrocínio J, de Sousa D, Frade JV
J Gen Intern Med 2023 Apr;38(5):1302. Epub 2022 Nov 28 doi: 10.1007/s11606-022-07968-6. PMID: 36443633Free PMC Article
Nevus of Ota with ipsilateral optic disc pigmentation and pigmentary glaucoma.
Rungta N, Ranjan A, Nishant P, Sinha S
Indian J Ophthalmol 2022 Jul;70(7):2656-2657. doi: 10.4103/ijo.IJO_2893_21. PMID: 35791191Free PMC Article
Optimizing Q-switched lasers for melasma and acquired dermal melanoses.
Aurangabadkar SJ
Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):10-17. doi: 10.4103/ijdvl.IJDVL_1086_16. PMID: 30027914

Therapy

Variables that predict response of nevus of ota to lasers.
Rani S, Sardana K
J Cosmet Dermatol 2019 Apr;18(2):464-468. Epub 2019 Feb 5 doi: 10.1111/jocd.12875. PMID: 30723997
Characteristics and management of Asian skin.
Chan IL, Cohen S, da Cunha MG, Maluf LC
Int J Dermatol 2019 Feb;58(2):131-143. Epub 2018 Jul 24 doi: 10.1111/ijd.14153. PMID: 30039861
Optimizing Q-switched lasers for melasma and acquired dermal melanoses.
Aurangabadkar SJ
Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):10-17. doi: 10.4103/ijdvl.IJDVL_1086_16. PMID: 30027914
Lasers and nevus of Ota: a comprehensive review.
Shah VV, Bray FN, Aldahan AS, Mlacker S, Nouri K
Lasers Med Sci 2016 Jan;31(1):179-85. Epub 2015 Nov 12 doi: 10.1007/s10103-015-1834-2. PMID: 26563954
Pigmentary disorders in India.
Pasricha JS, Khaitan BK, Dash S
Dermatol Clin 2007 Jul;25(3):343-52, viii. doi: 10.1016/j.det.2007.05.004. PMID: 17662900

Prognosis

The risk of glaucoma associated with phacomatosis cesioflammea and phacomatosis cesioflammeo-marmorata.
Huang S, Yang Y, Ouyang Z, Guo X, Zhan Z, Liu X, Chen Z, Xu J, Yu M
Eur J Dermatol 2022 Sep 1;32(5):589-596. doi: 10.1684/ejd.2022.4317. PMID: 36468718
Melanoma in the setting of nevus of Ota: a review for dermatologists.
Williams NM, Gurnani P, Labib A, Nuesi R, Nouri K
Int J Dermatol 2021 May;60(5):523-532. Epub 2020 Aug 17 doi: 10.1111/ijd.15135. PMID: 32808287
Variables that predict response of nevus of ota to lasers.
Rani S, Sardana K
J Cosmet Dermatol 2019 Apr;18(2):464-468. Epub 2019 Feb 5 doi: 10.1111/jocd.12875. PMID: 30723997
Dermal melanocytosis and associated disorders.
Franceschini D, Dinulos JG
Curr Opin Pediatr 2015 Aug;27(4):480-5. doi: 10.1097/MOP.0000000000000247. PMID: 26087431
Recurrence of nevus of Ota after successful treatment with Q-switched lasers.
Chan HH, Leung RS, Ying SY, Lai CF, Chua J, Kono T
Arch Dermatol 2000 Sep;136(9):1175-6. doi: 10.1001/archderm.136.9.1175. PMID: 10987887

Clinical prediction guides

High-fluence 1064nm Q-switched Nd:YAG laser treatment for ectopic Mongolian spot.
Shin JO, Roh D, Shin K, Kim HS, Kim BS, Kim MB, Ko HC
J Dermatolog Treat 2023 Dec;34(1):2255057. Epub 2023 Oct 2 doi: 10.1080/09546634.2023.2255057. PMID: 37781886
Changes in melanocytic nevi treated with laser hair removal: A systematic review.
Cices A, Dover JS, Labadie JG
Lasers Surg Med 2023 Sep;55(7):617-624. Epub 2023 Jul 26 doi: 10.1002/lsm.23712. PMID: 37493510
The risk of glaucoma associated with phacomatosis cesioflammea and phacomatosis cesioflammeo-marmorata.
Huang S, Yang Y, Ouyang Z, Guo X, Zhan Z, Liu X, Chen Z, Xu J, Yu M
Eur J Dermatol 2022 Sep 1;32(5):589-596. doi: 10.1684/ejd.2022.4317. PMID: 36468718
Variables that predict response of nevus of ota to lasers.
Rani S, Sardana K
J Cosmet Dermatol 2019 Apr;18(2):464-468. Epub 2019 Feb 5 doi: 10.1111/jocd.12875. PMID: 30723997
Characteristics and management of Asian skin.
Chan IL, Cohen S, da Cunha MG, Maluf LC
Int J Dermatol 2019 Feb;58(2):131-143. Epub 2018 Jul 24 doi: 10.1111/ijd.14153. PMID: 30039861

Recent systematic reviews

Changes in melanocytic nevi treated with laser hair removal: A systematic review.
Cices A, Dover JS, Labadie JG
Lasers Surg Med 2023 Sep;55(7):617-624. Epub 2023 Jul 26 doi: 10.1002/lsm.23712. PMID: 37493510
The risk of glaucoma associated with phacomatosis cesioflammea and phacomatosis cesioflammeo-marmorata.
Huang S, Yang Y, Ouyang Z, Guo X, Zhan Z, Liu X, Chen Z, Xu J, Yu M
Eur J Dermatol 2022 Sep 1;32(5):589-596. doi: 10.1684/ejd.2022.4317. PMID: 36468718
Comparing the efficacy and safety of Q-switched and picosecond lasers in the treatment of nevus of Ota: a systematic review and meta-analysis.
Williams NM, Gurnani P, Long J, Reynolds J, Pan Y, Suzuki T, Alhetheli GI, Nouri K
Lasers Med Sci 2021 Jun;36(4):723-733. Epub 2020 Aug 24 doi: 10.1007/s10103-020-03125-9. PMID: 32839837
Therapeutic options for management of Hori's nevus: A systematic review.
Kaur H, Sarma P, Kaur S, Kaur H, Prajapat M, Mahendiratta S, Kumar S, Thota P, Parsad D, Medhi B
Dermatol Ther 2020 Jan;33(1):e13167. Epub 2019 Dec 3 doi: 10.1111/dth.13167. PMID: 31714651
Comparison of clinical efficacy and complications between Q-switched alexandrite laser and Q-switched Nd:YAG laser on nevus of Ota: a systematic review and meta-analysis.
Yu P, Yu N, Diao W, Yang X, Feng Y, Qi Z
Lasers Med Sci 2016 Apr;31(3):581-91. Epub 2016 Feb 9 doi: 10.1007/s10103-016-1885-z. PMID: 26861980

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