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Neoplasms, Multiple Primary

MedGen UID:
14323
•Concept ID:
C0027663
•
Neoplastic Process
Synonyms: Multiple Primary Neoplasm; Multiple Primary Neoplasms; Multiple Primary Neoplasms, Synchronous; Neoplasm, Multiple Primary; Neoplasm, Synchronous; Neoplasms, Synchronous; Neoplasms, Synchronous Multiple Primary; Primary Neoplasm, Multiple; Primary Neoplasms, Multiple; Synchronous Multiple Primary Neoplasms; Synchronous Neoplasm; Synchronous Neoplasms

Definition

Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites. [from MeSH]

Professional guidelines

PubMed

Does synchronous early head and neck cancer with esophageal cancer need treatment after preoperative chemotherapy?
Kanamori K, Kurita D, Hirano Y, Ishiyama K, Oguma J, Masutomi K, Daiko H
Gen Thorac Cardiovasc Surg 2022 Mar;70(3):280-284. Epub 2021 Nov 27 doi: 10.1007/s11748-021-01744-9. PMID: 34837129
Genetic susceptibility to multiple primary neoplasms in the upper aero-digestive tract: genotype score and phenotype correlation.
Hussain T, Kotnis A, Sarin R, Mulherkar R
Cancer Lett 2013 May 10;332(1):46-54. Epub 2013 Jan 21 doi: 10.1016/j.canlet.2013.01.017. PMID: 23348701
Glutathione S-transferase M1 or T1 null genotype as a risk factor for developing multiple primary neoplasms in the upper aero-digestive tract, in Indian males using tobacco.
Jhavar S, Sarin R, Mulherkar R, Benner A, Agarwal JP, Dinshaw K
Oral Oncol 2004 Jan;40(1):84-91. doi: 10.1016/s1368-8375(03)00140-4. PMID: 14662420

Recent clinical studies

Etiology

Multiple primary melanomas: A literature review.
Apostu AP, Ungureanu L, Halmagyi SR, Trufin II, Șenilă SC
Medicine (Baltimore) 2023 Jul 28;102(30):e34378. doi: 10.1097/MD.0000000000034378. PMID: 37505174Free PMC Article
Multiple Primary Melanomas Occurring Around the Same Time: A Review of Terminology and Implications.
Shih S, Dai C, Shih T, Khachemoune A
J Drugs Dermatol 2020 May 1;19(5):471-474. PMID: 32484627
Synchronous Esophageal and Lung Cancer.
Mukerji AN, Wolf A
Thorac Surg Clin 2018 Feb;28(1):97-104. doi: 10.1016/j.thorsurg.2017.09.002. PMID: 29150043
Second primary cancers -  causes, incidence and the future.
Koubková L, Hrstka R, Dobes P, Vojtesek B, Vyzula R
Klin Onkol 2014;27(1):11-7. doi: 10.14735/amko201411. PMID: 24635432
Bilateral breast cancer.
Fracchia AA, Borgen PI
Semin Surg Oncol 1991 Sep-Oct;7(5):300-5. doi: 10.1002/ssu.2980070513. PMID: 1775816

Diagnosis

Synchronous laryngeal cancer.
Ciolofan MS, Anghelina F, Vlăescu AN, Mitroi MR, Căpitănescu AN, Ioniţă E, Ioniţă I, Ionovici N, Vrînceanu D, Mogoantă CA
Rom J Morphol Embryol 2024 Apr-Jun;65(2):309-315. doi: 10.47162/RJME.65.2.18. PMID: 39020546Free PMC Article
Lung Cancer Staging.
Kutob L, Schneider F
Surg Pathol Clin 2020 Mar;13(1):57-71. Epub 2019 Dec 18 doi: 10.1016/j.path.2019.10.003. PMID: 32005435
Multiple primary lung cancer: A literature review.
Romaszko AM, Doboszyńska A
Adv Clin Exp Med 2018 May;27(5):725-730. doi: 10.17219/acem/68631. PMID: 29790681
Primary and secondary neoplasms of the spleen.
Kaza RK, Azar S, Al-Hawary MM, Francis IR
Cancer Imaging 2010 Aug 13;10(1):173-82. doi: 10.1102/1470-7330.2010.0026. PMID: 20713317Free PMC Article
Multiple, giant fibroadenoma.
Musio F, Mozingo D, Otchy DP
Am Surg 1991 Jul;57(7):438-41. PMID: 1647714

Therapy

Breast Cancer and Multiple Primary Malignant Tumors: Case Report and Review of the Literature.
De Luca A, Frusone F, Vergine M, Cocchiara R, La Torre G, Ballesio L, Monti M, Amabile MI
In Vivo 2019 Jul-Aug;33(4):1313-1324. doi: 10.21873/invivo.11605. PMID: 31280224Free PMC Article
Nicotinamide: New Indications in Dermatology.
Escudero-Góngora MM, Fernández-Peñas P
Actas Dermosifiliogr 2016 Nov;107(9):777-778. Epub 2016 Jul 1 doi: 10.1016/j.ad.2016.05.015. PMID: 27377936
Gastrointestinal stromal tumors: diagnosis, therapy and follow-up care in Austria.
Bareck E, Ba-Ssalamah A, Brodowicz T, Eisterer W, Häfner M, Högenauer C, Kastner U, Kühr T, Längle F, Liegl-Atzwanger B, Schoppmann SF, Widmann G, Wrba F, Zacherl J, Ploner F; Austrian representatives of Medical and Surgical Oncology, Pathology, Radiology, Nuclear Medicine, Gastroenterology, and Laboratory Medicine
Wien Med Wochenschr 2013 Mar;163(5-6):137-52. Epub 2013 Mar 19 doi: 10.1007/s10354-013-0187-3. PMID: 23508516
Double pituitary adenomas.
Iacovazzo D, Bianchi A, Lugli F, Milardi D, Giampietro A, Lucci-Cordisco E, Doglietto F, Lauriola L, De Marinis L
Endocrine 2013 Apr;43(2):452-7. Epub 2013 Jan 17 doi: 10.1007/s12020-013-9876-3. PMID: 23325364
Non-invasive breast carcinoma.
Posner MC, Wolmark N
Breast Cancer Res Treat 1992;21(3):155-64. doi: 10.1007/BF01974998. PMID: 1325215

Prognosis

Multiple primary melanomas: A literature review.
Apostu AP, Ungureanu L, Halmagyi SR, Trufin II, Șenilă SC
Medicine (Baltimore) 2023 Jul 28;102(30):e34378. doi: 10.1097/MD.0000000000034378. PMID: 37505174Free PMC Article
Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.
Nie Y, Wang X, Yang F, Zhou Z, Wang J, Chen K
Clin Lung Cancer 2021 Jul;22(4):341-350.e3. Epub 2020 Nov 5 doi: 10.1016/j.cllc.2020.10.022. PMID: 33243621
Clinicopathologic features and prognosis of synchronous and metachronous multiple primary colorectal cancer.
Zhang C, Cui M, Xing J, Yang H, Yao Z, Zhang N, Su X
Clin Transl Oncol 2021 Feb;23(2):335-343. Epub 2020 Jun 26 doi: 10.1007/s12094-020-02426-3. PMID: 32592156
Multiple Primary Melanomas Occurring Around the Same Time: A Review of Terminology and Implications.
Shih S, Dai C, Shih T, Khachemoune A
J Drugs Dermatol 2020 May 1;19(5):471-474. PMID: 32484627
Second primary cancers -  causes, incidence and the future.
Koubková L, Hrstka R, Dobes P, Vojtesek B, Vyzula R
Klin Onkol 2014;27(1):11-7. doi: 10.14735/amko201411. PMID: 24635432

Clinical prediction guides

Genetic and immune characteristics of multiple primary lung cancers and lung metastases.
Yang R, Li P, Wang D, Wang L, Yin J, Yu B, Li M, Wang S, Wang Y
Thorac Cancer 2021 Oct;12(19):2544-2550. Epub 2021 Sep 12 doi: 10.1111/1759-7714.14134. PMID: 34510768Free PMC Article
Multiomics analysis reveals a distinct response mechanism in multiple primary lung adenocarcinoma after neoadjuvant immunotherapy.
Zhang C, Yin K, Liu SY, Yan LX, Su J, Wu YL, Zhang XC, Zhong WZ, Yang XN
J Immunother Cancer 2021 Apr;9(4) doi: 10.1136/jitc-2020-002312. PMID: 33820821Free PMC Article
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.
Pritchard AL, Johansson PA, Nathan V, Howlie M, Symmons J, Palmer JM, Hayward NK
PLoS One 2018;13(4):e0194098. Epub 2018 Apr 11 doi: 10.1371/journal.pone.0194098. PMID: 29641532Free PMC Article
Multiple primary cancers in BRCA 1/2 carriers - A review of literature and our observations.
Markowska A, Lubin J, Markowska J, Kasprzak B, Chajewska-Czekańska M, Madry R, Stawicka M
Eur J Gynaecol Oncol 2017;38(3):361-363. PMID: 29693873
Bilateral breast cancer.
Fracchia AA, Borgen PI
Semin Surg Oncol 1991 Sep-Oct;7(5):300-5. doi: 10.1002/ssu.2980070513. PMID: 1775816

Recent systematic reviews

Surgical Prognosis of Synchronous Multiple Primary Lung Cancer: Systematic Review and Meta-Analysis.
Nie Y, Wang X, Yang F, Zhou Z, Wang J, Chen K
Clin Lung Cancer 2021 Jul;22(4):341-350.e3. Epub 2020 Nov 5 doi: 10.1016/j.cllc.2020.10.022. PMID: 33243621
Survival in patients with multiple primary melanomas: Systematic review and meta-analysis.
Peek G, Olsen CM, Baade P, Youlden DR, Aitken JF, Green AC, Khosrotehrani K
J Am Acad Dermatol 2020 Nov;83(5):1406-1414. Epub 2020 Apr 1 doi: 10.1016/j.jaad.2020.03.076. PMID: 32246965
Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654
Prognosis of synchronous and metachronous multiple primary lung cancers: systematic review and meta-analysis.
Jiang L, He J, Shi X, Shen J, Liang W, Yang C, He J
Lung Cancer 2015 Mar;87(3):303-10. Epub 2015 Jan 14 doi: 10.1016/j.lungcan.2014.12.013. PMID: 25617985
Diagnosis of multiple primary lung cancer: a systematic review.
Xue X, Liu Y, Pan L, Wang Y, Wang K, Zhang M, Wang P, Wang J
J Int Med Res 2013 Dec;41(6):1779-87. doi: 10.1177/0300060513504707. PMID: 24265329

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