Definition

A failure of spermatogenesis to progress beyond the round spermatid stage. The round spermatid is the first haploid cells produced during spermatogenesis and normally further develop into mature spermatozoa. This abnormality can be visualized with testicular biopsy and is characterized seminiferous tubules with increased numbers of round spermatids with few or no mature spermatozoa. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRound spermatid arrest

Abnormality of the genital system
- Abnormality of reproductive system physiology
  - Abnormal male reproductive system physiology
    - Functional abnormality of male internal genitalia
      - Abnormal spermatogenesis
        Spermatogenesis maturation arrest
        Round spermatid arrest

Conditions with this feature

Spermatogenic failure 14

MedGen UID:: 862891
•Concept ID:: C4014454
•: Disease or Syndrome

Any azoospermia in which the cause of the disease is a mutation in the ZMYND15 gene.

See: Condition Record

Spermatogenic failure 14

Professional guidelines

PubMed

Bortezomib treatment causes long-term testicular dysfunction in young male mice.

Hou M, Eriksson E, Svechnikov K, Jahnukainen K, Söder O, Meinhardt A, Sävendahl L
Mol Cancer 2014 Jun 20;13:155. doi: 10.1186/1476-4598-13-155. PMID: 24950741 Free PMC Article

Treatment of severe male infertility by micromanipulation-assisted fertilization: news and views.

Tesarik J, Mendoza C, Greco E
Front Biosci 1998 Dec 15;3:E238-46. doi: 10.2741/a383. PMID: 9851915

See all (2)

Recent clinical studies

Diagnosis

The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.

Wyrwoll MJ, Gaasbeek CM, Golubickaite I, Stakaitis R, Oud MS, Nagirnaja L, Dion C, Sindi EB, Leitch HG, Jayasena CN, Sironen A, Dicke AK, Rotte N, Stallmeyer B, Kliesch S, Grangeiro CHP, Araujo TF, Lasko P; Genetics of Male Infertility Initiative (GEMINI) consortium, D'Hauwers K, Smits RM, Ramos L, Xavier MJ, Conrad DF, Almstrup K, Veltman JA, Tüttelmann F, van der Heijden GW
Am J Hum Genet 2022 Oct 6;109(10):1850-1866. Epub 2022 Sep 22 doi: 10.1016/j.ajhg.2022.09.002. PMID: 36150389 Free PMC Article

See all (1)

Therapy

Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?

Vouk K, Hudler P, Strmsnik L, Fink M, Majdic G, Zorn B, Lalli E, Sassone-Corsi P, Debeljak N, Komel R, Rozman D
Mol Hum Reprod 2005 Aug;11(8):567-74. Epub 2005 Sep 2 doi: 10.1093/molehr/gah209. PMID: 16143638

See all (1)

Prognosis

The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.

Wyrwoll MJ, Gaasbeek CM, Golubickaite I, Stakaitis R, Oud MS, Nagirnaja L, Dion C, Sindi EB, Leitch HG, Jayasena CN, Sironen A, Dicke AK, Rotte N, Stallmeyer B, Kliesch S, Grangeiro CHP, Araujo TF, Lasko P; Genetics of Male Infertility Initiative (GEMINI) consortium, D'Hauwers K, Smits RM, Ramos L, Xavier MJ, Conrad DF, Almstrup K, Veltman JA, Tüttelmann F, van der Heijden GW
Am J Hum Genet 2022 Oct 6;109(10):1850-1866. Epub 2022 Sep 22 doi: 10.1016/j.ajhg.2022.09.002. PMID: 36150389 Free PMC Article

Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?

Vouk K, Hudler P, Strmsnik L, Fink M, Majdic G, Zorn B, Lalli E, Sassone-Corsi P, Debeljak N, Komel R, Rozman D
Mol Hum Reprod 2005 Aug;11(8):567-74. Epub 2005 Sep 2 doi: 10.1093/molehr/gah209. PMID: 16143638

See all (2)

Clinical prediction guides

The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.

Wyrwoll MJ, Gaasbeek CM, Golubickaite I, Stakaitis R, Oud MS, Nagirnaja L, Dion C, Sindi EB, Leitch HG, Jayasena CN, Sironen A, Dicke AK, Rotte N, Stallmeyer B, Kliesch S, Grangeiro CHP, Araujo TF, Lasko P; Genetics of Male Infertility Initiative (GEMINI) consortium, D'Hauwers K, Smits RM, Ramos L, Xavier MJ, Conrad DF, Almstrup K, Veltman JA, Tüttelmann F, van der Heijden GW
Am J Hum Genet 2022 Oct 6;109(10):1850-1866. Epub 2022 Sep 22 doi: 10.1016/j.ajhg.2022.09.002. PMID: 36150389 Free PMC Article

Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?

Vouk K, Hudler P, Strmsnik L, Fink M, Majdic G, Zorn B, Lalli E, Sassone-Corsi P, Debeljak N, Komel R, Rozman D
Mol Hum Reprod 2005 Aug;11(8):567-74. Epub 2005 Sep 2 doi: 10.1093/molehr/gah209. PMID: 16143638

See all (2)

Synonyms:	Late spermatogenesis maturation arrest; Maturation arrest of spermatogenesis at spermatid stage

HPO:	HP:0031040

MedGen

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Round spermatid arrest

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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Practice guidelines

Consumer resources

Reviews

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