Benign Osteoclastic Giant Cell-Rich Tumor of Bone

MedGen UID:: 1380763
•Concept ID:: C4316923
•: Neoplastic Process

Synonym:

Benign Osteoclastic Giant Cell-Rich Tumor of the Bone

Definition

A giant cell tumor that arises from the bone and is characterized by the absence of local aggression and lack of metastatic potential. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign Osteoclastic Giant Cell-Rich Tumor of Bone

Disease
- Disorder by Site
  - Connective and Soft Tissue Disorder
    - Connective tissue disorder
      - Bone Neoplasm
        Bone benign neoplasm
        Benign Osteoclastic Giant Cell-Rich Tumor of Bone
        Giant Cell Lesion of Small Bones

Recent clinical studies

Etiology

Recurrent Fusion of the Genes for High-mobility Group AT-hook 2 (HMGA2) and Nuclear Receptor Co-repressor 2 (NCOR2) in Osteoclastic Giant Cell-rich Tumors of Bone.

Panagopoulos I, Andersen K, Gorunova L, Lund-Iversen M, Lobmaier I, Heim S
Cancer Genomics Proteomics 2022 Mar-Apr;19(2):163-177. doi: 10.21873/cgp.20312. PMID: 35181586 Free PMC Article

Diagnostic accuracies of intraoperative frozen section and permanent section examinations for histological grades during open biopsy of bone tumors.

Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Tada K, Higuchi T, Yonezawa H, Morinaga S, Araki Y, Asano Y, Ikeda H, Nojima T, Tsuchiya H
Int J Clin Oncol 2021 Mar;26(3):613-619. Epub 2020 Nov 23 doi: 10.1007/s10147-020-01836-1. PMID: 33225397

Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone.

Lipplaa A, Dijkstra S, Gelderblom H
Curr Opin Oncol 2019 Jul;31(4):329-335. doi: 10.1097/CCO.0000000000000529. PMID: 30844887 Free PMC Article

A diagnosis of giant cell-rich tumour of bone is supported by p63 immunohistochemistry, when more than 50 % of cells is stained.

Maues De Paula A, Vasiljevic A, Giorgi R, Gomez-Brouchet A, Aubert S, Leroy X, Duval H, de Pinieux G, Bouvier C
Virchows Arch 2014 Oct;465(4):487-94. Epub 2014 Aug 7 doi: 10.1007/s00428-014-1637-z. PMID: 25100342

Giant-cell-rich pseudotumour in Paget's disease.

Gamage NM, Kashima TG, McNally MA, Gibbons CL, Smith R, Ostlere SJ, Athanasou NA
Skeletal Radiol 2013 Apr;42(4):595-9. Epub 2012 Dec 29 doi: 10.1007/s00256-012-1558-3. PMID: 23275027

See all (7)

Diagnosis

Molecular and immunohistochemical testing of bone tumours: review and update.

Kovacs SK, Manassaporn A, Nielsen GP, Hung YP
Histopathology 2023 May;82(6):794-811. Epub 2022 Dec 16 doi: 10.1111/his.14845. PMID: 36424903

Giant cell tumor of bone in an eighteenth-century Italian mummy.

Ventura L, Petrella E, Piciucchi S, Cilli E, Luiselli D, Feeney RNM, Traversari M
Virchows Arch 2021 Dec;479(6):1255-1261. Epub 2021 Aug 30 doi: 10.1007/s00428-021-03192-5. PMID: 34462806 Free PMC Article

Diagnostic accuracies of intraoperative frozen section and permanent section examinations for histological grades during open biopsy of bone tumors.

A diagnosis of giant cell-rich tumour of bone is supported by p63 immunohistochemistry, when more than 50 % of cells is stained.

Giant-cell-rich pseudotumour in Paget's disease.

Gamage NM, Kashima TG, McNally MA, Gibbons CL, Smith R, Ostlere SJ, Athanasou NA
Skeletal Radiol 2013 Apr;42(4):595-9. Epub 2012 Dec 29 doi: 10.1007/s00256-012-1558-3. PMID: 23275027

See all (9)

Therapy

Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone.

Lipplaa A, Dijkstra S, Gelderblom H
Curr Opin Oncol 2019 Jul;31(4):329-335. doi: 10.1097/CCO.0000000000000529. PMID: 30844887 Free PMC Article

See all (1)

Prognosis

Giant cell tumor of bone in an eighteenth-century Italian mummy.

Giant-cell-rich pseudotumour in Paget's disease.

Gamage NM, Kashima TG, McNally MA, Gibbons CL, Smith R, Ostlere SJ, Athanasou NA
Skeletal Radiol 2013 Apr;42(4):595-9. Epub 2012 Dec 29 doi: 10.1007/s00256-012-1558-3. PMID: 23275027

Primary giant cell tumor of soft tissue of the groin - a case of 46 years duration.

Boneschi V, Parafioriti A, Armiraglio E, Gaiani F, Brambilla L
J Cutan Pathol 2009 Oct;36 Suppl 1:20-4. Epub 2009 Feb 4 doi: 10.1111/j.1600-0560.2008.01202.x. PMID: 19222697

Chondroblastoma: varied histologic appearance, potential diagnostic pitfalls, and clinicopathologic features associated with local recurrence.

de Silva MV, Reid R
Ann Diagn Pathol 2003 Aug;7(4):205-13. doi: 10.1016/s1092-9134(03)00048-0. PMID: 12913842

Giant cell tumors of soft tissue: a clinicopathologic study of 18 benign and malignant tumors.

O'Connell JX, Wehrli BM, Nielsen GP, Rosenberg AE
Am J Surg Pathol 2000 Mar;24(3):386-95. doi: 10.1097/00000478-200003000-00007. PMID: 10716152

See all (5)