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Metastatic malignant neoplasm in the spinal cord

MedGen UID:
138075
•Concept ID:
C0347016
•
Neoplastic Process
Synonyms: Metastasis to Spinal Cord; Metastasis to spinal cord; metastasis to spinal cord; Metastatic Malignant Neoplasm in the Spinal Cord; metastatic malignant neoplasm in the spinal cord; Metastatic malignant neoplasm of spinal cord; Metastatic malignant neoplasm to spinal cord; Metastatic Malignant Neoplasm to the Spinal Cord; Metastatic malignant neoplasm to the spinal cord; Metastatic Neoplasm to the Spinal Cord; Metastatic neoplasm to the spinal cord; Metastatic Tumor to the Spinal Cord; Metastatic tumor to the spinal cord; Metastatic tumour to the spinal cord; Secondary malignant neoplasm of spinal cord; Secondary Malignant Neoplasm to the Spinal Cord; Secondary malignant neoplasm to the spinal cord; Secondary Malignant Tumor to the Spinal Cord; Secondary malignant tumor to the spinal cord; Secondary malignant tumour to the spinal cord
SNOMED CT: Metastasis to spinal cord (94600009); Secondary malignant neoplasm of spinal cord (94600009); Metastatic malignant neoplasm to spinal cord (94600009); Metastatic malignant neoplasm of spinal cord (94600009)
 
Monarch Initiative: MONDO:0044912

Definition

A malignant neoplasm that has spread to the spinal cord from another anatomic site or system. Representative examples include carcinoma, lymphoma, and melanoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic malignant neoplasm in the spinal cord

Professional guidelines

PubMed

Ependymoma: Evaluation and Management Updates.
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Bone Pain in Cancer Patients: Mechanisms and Current Treatment.
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954

Recent clinical studies

Etiology

Consensus Contouring Guidelines for Postoperative Stereotactic Body Radiation Therapy for Metastatic Solid Tumor Malignancies to the Spine.
Redmond KJ, Robertson S, Lo SS, Soltys SG, Ryu S, McNutt T, Chao ST, Yamada Y, Ghia A, Chang EL, Sheehan J, Sahgal A
Int J Radiat Oncol Biol Phys 2017 Jan 1;97(1):64-74. Epub 2016 Sep 17 doi: 10.1016/j.ijrobp.2016.09.014. PMID: 27843035Free PMC Article
Consensus guidelines for postoperative stereotactic body radiation therapy for spinal metastases: results of an international survey.
Redmond KJ, Lo SS, Soltys SG, Yamada Y, Barani IJ, Brown PD, Chang EL, Gerszten PC, Chao ST, Amdur RJ, De Salles AA, Guckenberger M, Teh BS, Sheehan J, Kersh CR, Fehlings MG, Sohn MJ, Chang UK, Ryu S, Gibbs IC, Sahgal A
J Neurosurg Spine 2017 Mar;26(3):299-306. Epub 2016 Nov 11 doi: 10.3171/2016.8.SPINE16121. PMID: 27834628Free PMC Article
Reliability analysis of the epidural spinal cord compression scale.
Bilsky MH, Laufer I, Fourney DR, Groff M, Schmidt MH, Varga PP, Vrionis FD, Yamada Y, Gerszten PC, Kuklo TR
J Neurosurg Spine 2010 Sep;13(3):324-8. doi: 10.3171/2010.3.SPINE09459. PMID: 20809724
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708
Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial.
Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B
Lancet 2005 Aug 20-26;366(9486):643-8. doi: 10.1016/S0140-6736(05)66954-1. PMID: 16112300

Diagnosis

Metastatic spinal cord compression.
Patnaik S, Turner J, Inaparthy P, Kieffer WK
Br J Hosp Med (Lond) 2020 Apr 2;81(4):1-10. doi: 10.12968/hmed.2019.0399. PMID: 32339020
Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review.
Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, Abrahm JL
J Clin Oncol 2019 Jan 1;37(1):61-71. Epub 2018 Nov 5 doi: 10.1200/JCO.2018.78.1211. PMID: 30395488
Metastatic spinal cord compression: diagnosis and management.
Al-Qurainy R, Collis E
BMJ 2016 May 19;353:i2539. doi: 10.1136/bmj.i2539. PMID: 27199232
Spinal cord involvement.
Oberndorfer S, Grisold W
Handb Clin Neurol 2012;105:767-80. doi: 10.1016/B978-0-444-53502-3.00023-9. PMID: 22230533
Reliability analysis of the epidural spinal cord compression scale.
Bilsky MH, Laufer I, Fourney DR, Groff M, Schmidt MH, Varga PP, Vrionis FD, Yamada Y, Gerszten PC, Kuklo TR
J Neurosurg Spine 2010 Sep;13(3):324-8. doi: 10.3171/2010.3.SPINE09459. PMID: 20809724

Therapy

Metastatic spinal cord compression.
Patnaik S, Turner J, Inaparthy P, Kieffer WK
Br J Hosp Med (Lond) 2020 Apr 2;81(4):1-10. doi: 10.12968/hmed.2019.0399. PMID: 32339020
Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review.
Lawton AJ, Lee KA, Cheville AL, Ferrone ML, Rades D, Balboni TA, Abrahm JL
J Clin Oncol 2019 Jan 1;37(1):61-71. Epub 2018 Nov 5 doi: 10.1200/JCO.2018.78.1211. PMID: 30395488
Reliability analysis of the epidural spinal cord compression scale.
Bilsky MH, Laufer I, Fourney DR, Groff M, Schmidt MH, Varga PP, Vrionis FD, Yamada Y, Gerszten PC, Kuklo TR
J Neurosurg Spine 2010 Sep;13(3):324-8. doi: 10.3171/2010.3.SPINE09459. PMID: 20809724
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708
Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial.
Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Mohiuddin M, Young B
Lancet 2005 Aug 20-26;366(9486):643-8. doi: 10.1016/S0140-6736(05)66954-1. PMID: 16112300

Prognosis

Surgery for spina bifida occulta: spinal lipoma and tethered spinal cord.
Morota N, Sakamoto H
Childs Nerv Syst 2023 Oct;39(10):2847-2864. Epub 2023 Jul 8 doi: 10.1007/s00381-023-06024-w. PMID: 37421423
Combined intramedullary and intradural extramedullary spinal metastases in malignant melanoma.
O'Reilly MK, Sugrue G, Byrne D, MacMahon P
BMJ Case Rep 2017 Mar 25;2017 doi: 10.1136/bcr-2017-220031. PMID: 28343150Free PMC Article
Metastatic spinal cord compression: diagnosis and management.
Al-Qurainy R, Collis E
BMJ 2016 May 19;353:i2539. doi: 10.1136/bmj.i2539. PMID: 27199232
Spinal cord glioma metastasizing to the brain.
Saidha S, Pardo CA
Arch Neurol 2012 Aug;69(8):1078-9. doi: 10.1001/archneurol.2012.8. PMID: 22529250
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708

Clinical prediction guides

Conventional Radiotherapy and Stereotactic Radiosurgery in the Management of Metastatic Spine Disease.
Zhang HR, Li JK, Yang XG, Qiao RQ, Hu YC
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820945798. doi: 10.1177/1533033820945798. PMID: 32757820Free PMC Article
The role of 5-aminolevulinic acid in spinal tumor surgery: a review.
Wainwright JV, Endo T, Cooper JB, Tominaga T, Schmidt MH
J Neurooncol 2019 Feb;141(3):575-584. Epub 2018 Dec 29 doi: 10.1007/s11060-018-03080-0. PMID: 30594965Free PMC Article
Instability and impending instability in patients with vertebral metastatic disease.
Leone A, Cianfoni A, Zecchi V, Cortese MC, Rumi N, Colosimo C
Skeletal Radiol 2019 Feb;48(2):195-207. Epub 2018 Aug 1 doi: 10.1007/s00256-018-3032-3. PMID: 30069584
Reliability analysis of the epidural spinal cord compression scale.
Bilsky MH, Laufer I, Fourney DR, Groff M, Schmidt MH, Varga PP, Vrionis FD, Yamada Y, Gerszten PC, Kuklo TR
J Neurosurg Spine 2010 Sep;13(3):324-8. doi: 10.3171/2010.3.SPINE09459. PMID: 20809724
Clinical features of metastatic bone disease and risk of skeletal morbidity.
Coleman RE
Clin Cancer Res 2006 Oct 15;12(20 Pt 2):6243s-6249s. doi: 10.1158/1078-0432.CCR-06-0931. PMID: 17062708

Recent systematic reviews

Malignant spinal cord compression in the paediatric population-a systematic review, meta-analysis.
Quraishi NA, Palliyil N, Hassanin MA, D'Aquino D, Shetaiwi A, Walker D
Eur Spine J 2023 Dec;32(12):4306-4313. Epub 2023 Jun 20 doi: 10.1007/s00586-023-07820-3. PMID: 37338630
Vertebroplasty and Kyphoplasty for Metastatic Spinal Lesions: A Systematic Review.
Sadeghi-Naini M, Aarabi S, Shokraneh F, Janani L, Vaccaro AR, Rahimi-Movaghar V
Clin Spine Surg 2018 Jun;31(5):203-210. doi: 10.1097/BSD.0000000000000601. PMID: 29283901
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article
Breast cancer (metastatic).
Stebbing J, Slater S, Slevin M
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454050Free PMC Article

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