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Internal ophthalmoplegia

MedGen UID:
137925
•Concept ID:
C0339693
•
Finding; Finding
Synonyms: Internal Ophthalmoplegia; Internal Ophthalmoplegias; Ophthalmoplegia, Internal; Ophthalmoplegias, Internal
SNOMED CT: Internal ophthalmoplegia (232146005)
 
HPO: HP:0007942

Definition

Paralysis of the iris and ciliary apparatus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInternal ophthalmoplegia

Conditions with this feature

Ophthalmoplegia, familial total, with iris transillumination
MedGen UID:
371665
•Concept ID:
C1833836
•
Disease or Syndrome
See: Condition Record
Ophthalmoplegia, familial total, with iris transillumination

Professional guidelines

PubMed

Diagnosis and treatment of retrobulbar haematomas following blunt orbital trauma: a description of eight cases.
Gerbino G, Ramieri GA, Nasi A
Int J Oral Maxillofac Surg 2005 Mar;34(2):127-31. doi: 10.1016/j.ijom.2004.05.001. PMID: 15695039

Recent clinical studies

Etiology

Isolated squamous cell carcinoma of the orbital apex.
Peckinpaugh JL, Winn BJ, Barrett RV, Jacobsen DW, Sires BS, Meyer DR, Jian-Amadi A
Ophthalmic Plast Reconstr Surg 2012 May-Jun;28(3):e72-4. doi: 10.1097/IOP.0b013e31822ddd91. PMID: 22082594
Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody.
Lee SH, Lim GH, Kim JS, Oh SY, Kim JK, Cha JK, Yun CH, Kang JK, Lee H, Song HK, Chung KC
Neurology 2008 Aug 5;71(6):426-9. doi: 10.1212/01.wnl.0000324266.95814.74. PMID: 18678825
Diagnosis and treatment of retrobulbar haematomas following blunt orbital trauma: a description of eight cases.
Gerbino G, Ramieri GA, Nasi A
Int J Oral Maxillofac Surg 2005 Mar;34(2):127-31. doi: 10.1016/j.ijom.2004.05.001. PMID: 15695039
Relative pupil-sparing third nerve palsy: etiology and clinical variables predictive of a mass.
Jacobson DM
Neurology 2001 Mar 27;56(6):797-8. doi: 10.1212/wnl.56.6.797. PMID: 11274322
Argon versus krypton panretinal photocoagulation side effects on the anterior segment.
Menchini U, Scialdone A, Pietroni C, Carones F, Brancato R
Ophthalmologica 1990;201(2):66-70. doi: 10.1159/000310129. PMID: 2234817

Diagnosis

Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies.
Murakami K, Kajimoto Y, Ito H
Intern Med 2022 Oct 15;61(20):3121-3124. Epub 2022 Apr 2 doi: 10.2169/internalmedicine.8416-21. PMID: 35370231Free PMC Article
Isolated Bilateral Internal Ophthalmoplegia as an Atypical Initial Presentation of anti-GQ1b Antibody Syndrome.
Jebaraj AP, Swiston CJ, Vegunta S, Warner JEA
J Neuroophthalmol 2022 Mar 1;42(1):e389-e390. Epub 2021 Jul 23 doi: 10.1097/WNO.0000000000001314. PMID: 34310460
Relative pupil-sparing third nerve palsy: etiology and clinical variables predictive of a mass.
Jacobson DM
Neurology 2001 Mar 27;56(6):797-8. doi: 10.1212/wnl.56.6.797. PMID: 11274322
Neuro-ophthalmic sarcoidosis.
Turner RG, James DG, Friedmann AI, Vijendram M, Davies JP
Br J Ophthalmol 1975 Nov;59(11):657-63. doi: 10.1136/bjo.59.11.657. PMID: 1203222Free PMC Article
Unilateral internal ophthalmoplegia with intracranial aneurysm.
Payne JW, Adamkiewicz J Jr
Am J Ophthalmol 1969 Aug;68(2):349-52. doi: 10.1016/0002-9394(69)94084-7. PMID: 5798817

Therapy

Acute Oropharyngeal Palsy Following Bilateral Adie's Tonic Pupils Associated with Anti-GT1a and GQ1b IgG Antibodies.
Murakami K, Kajimoto Y, Ito H
Intern Med 2022 Oct 15;61(20):3121-3124. Epub 2022 Apr 2 doi: 10.2169/internalmedicine.8416-21. PMID: 35370231Free PMC Article
Heerfordt syndrome with internal ophthalmoplegia.
Blair MP, Rizen M
Arch Ophthalmol 2005 Jul;123(7):1017. doi: 10.1001/archopht.123.7.1017. PMID: 16009851
Presentations of cranial nerve involvement in two patients with Herpes zoster ophthalmicus.
Sodhi PK, Goel JL
J Commun Dis 2001 Jun;33(2):130-5. PMID: 12170933
Argon versus krypton panretinal photocoagulation side effects on the anterior segment.
Menchini U, Scialdone A, Pietroni C, Carones F, Brancato R
Ophthalmologica 1990;201(2):66-70. doi: 10.1159/000310129. PMID: 2234817
Internal 'ophthalmoplegia' in myasthenia gravis.
Herishanu Y, Lavy S
Ophthalmologica 1971;163(5):302-5. doi: 10.1159/000306658. PMID: 5157885

Prognosis

Benign food-borne type B botulism presenting as unilateral internal ophthalmoplegia: a case report.
Crescenzo F, Del Colle R, Ajena D, Stecca M, Ferigo L, Rossi F, Turazzini M
BMC Neurol 2022 Nov 28;22(1):444. doi: 10.1186/s12883-022-02939-0. PMID: 36443684Free PMC Article
Orbital apex syndrome as a complication of herpes zoster ophthalmicus.
Chandrasekharan A, Gandhi U, Badakere A, Sangwan V
BMJ Case Rep 2017 Feb 24;2017 doi: 10.1136/bcr-2016-217382. PMID: 28237946Free PMC Article
Isolated squamous cell carcinoma of the orbital apex.
Peckinpaugh JL, Winn BJ, Barrett RV, Jacobsen DW, Sires BS, Meyer DR, Jian-Amadi A
Ophthalmic Plast Reconstr Surg 2012 May-Jun;28(3):e72-4. doi: 10.1097/IOP.0b013e31822ddd91. PMID: 22082594
Diagnosis and treatment of retrobulbar haematomas following blunt orbital trauma: a description of eight cases.
Gerbino G, Ramieri GA, Nasi A
Int J Oral Maxillofac Surg 2005 Mar;34(2):127-31. doi: 10.1016/j.ijom.2004.05.001. PMID: 15695039
Relative pupil-sparing third nerve palsy: etiology and clinical variables predictive of a mass.
Jacobson DM
Neurology 2001 Mar 27;56(6):797-8. doi: 10.1212/wnl.56.6.797. PMID: 11274322

Clinical prediction guides

Delayed internal ophthalmoplegia and amblyopia following chickenpox.
Orssaud C, Roche O, El Dirani H, Dufier JL
Eur J Pediatr 2006 Oct;165(10):728-9. Epub 2006 May 12 doi: 10.1007/s00431-006-0155-7. PMID: 16691403
Relative pupil-sparing third nerve palsy: etiology and clinical variables predictive of a mass.
Jacobson DM
Neurology 2001 Mar 27;56(6):797-8. doi: 10.1212/wnl.56.6.797. PMID: 11274322
Argon versus krypton panretinal photocoagulation side effects on the anterior segment.
Menchini U, Scialdone A, Pietroni C, Carones F, Brancato R
Ophthalmologica 1990;201(2):66-70. doi: 10.1159/000310129. PMID: 2234817
Internal ophthalmoplegia and cranial neuropathy without external ophthalmoplegia. A report of 2 cases.
Hammond-Tooke GD, Voll CL
S Afr Med J 1988 May 7;73(9):554-6. PMID: 3375951
Ocular and orbital toxicity following intracarotid injection of BCNU (carmustine) and cisplatinum for malignant gliomas.
Miller DF, Bay JW, Lederman RJ, Purvis JD, Rogers LR, Tomsak RL
Ophthalmology 1985 Mar;92(3):402-6. doi: 10.1016/s0161-6420(85)34036-8. PMID: 2986069

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