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Glomerular extracapillary hypercellularity

MedGen UID:
1370662
•Concept ID:
C4476733
•
Finding
Synonyms: Extracapillary glomerular hypercellularity; Extracapillary hypercellularity
 
HPO: HP:0025364

Definition

Hypercellularity (increased number of cells) in the renal glomerulus but external to the glomerular capillaries, i.e., in the Bowman space or more than one layer of parietal or visceral epithelial cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular extracapillary hypercellularity

Professional guidelines

PubMed

Methylprednisolone pulse therapy in the treatment of severe forms of Schönlein-Henoch purpura nephritis.
Niaudet P, Habib R
Pediatr Nephrol 1998 Apr;12(3):238-43. doi: 10.1007/s004670050446. PMID: 9630046

Recent clinical studies

Etiology

IgA nephropathy in children with minimal proteinuria: to biopsy or not to biopsy?
Cambier A, Roy JP, Dossier C, Patey N, Rabant M, Boyer O, Delbet JD, Lapeyraque AL, Hogan J
Pediatr Nephrol 2024 Mar;39(3):781-787. Epub 2023 Sep 12 doi: 10.1007/s00467-023-06121-7. PMID: 37698655
Clinicopathological features and outcomes of diabetic kidney disease with extracapillary hypercellularity: a Japanese single-center experience.
Saito A, Komatsuda A, Saito M, Kaga H, Abe F, Sawamura M, Nara M, Sato R, Wakui H, Takahashi N
Clin Exp Nephrol 2020 Jun;24(6):509-517. Epub 2020 Feb 10 doi: 10.1007/s10157-020-01859-y. PMID: 32037471
Segmental Sclerosis and Extracapillary Hypercellularity Predict Diabetic ESRD.
Mottl AK, Gasim A, Schober FP, Hu Y, Dunnon AK, Hogan SL, Jennette JC
J Am Soc Nephrol 2018 Feb;29(2):694-703. Epub 2017 Nov 27 doi: 10.1681/ASN.2017020192. PMID: 29180393Free PMC Article
Validation study of Oxford Classification of IgA Nephropathy: the significance of extracapillary hypercellularity and mesangial IgG immunostaining.
Ştefan G, Ismail G, Stancu S, Zugravu A, Andronesi A, Mandache E, Mircescu G
Pathol Int 2016 Aug;66(8):453-9. Epub 2016 Jul 21 doi: 10.1111/pin.12442. PMID: 27439692
Morphologic variants of focal segmental glomerulosclerosis and their significance.
Stokes MB, D'Agati VD
Adv Chronic Kidney Dis 2014 Sep;21(5):400-7. doi: 10.1053/j.ackd.2014.02.010. PMID: 25168828

Diagnosis

IgA nephropathy in children with minimal proteinuria: to biopsy or not to biopsy?
Cambier A, Roy JP, Dossier C, Patey N, Rabant M, Boyer O, Delbet JD, Lapeyraque AL, Hogan J
Pediatr Nephrol 2024 Mar;39(3):781-787. Epub 2023 Sep 12 doi: 10.1007/s00467-023-06121-7. PMID: 37698655
Clinical course of Immunoglobulin A nephropathy with crescents in a multi-ethnic Southeast Asian cohort.
Lim CC, Baikunje S, Choo JCJ, Tan PH, Foo M, Woo KT
Nephrology (Carlton) 2020 Sep;25(9):708-713. Epub 2020 Jun 8 doi: 10.1111/nep.13723. PMID: 32400945
Clinicopathological features and outcomes of diabetic kidney disease with extracapillary hypercellularity: a Japanese single-center experience.
Saito A, Komatsuda A, Saito M, Kaga H, Abe F, Sawamura M, Nara M, Sato R, Wakui H, Takahashi N
Clin Exp Nephrol 2020 Jun;24(6):509-517. Epub 2020 Feb 10 doi: 10.1007/s10157-020-01859-y. PMID: 32037471
Prognostic nomogram and score to predict renal survival of patients with biopsy-proven diabetic nephropathy.
Jiang S, Yu T, Zhang Z, Fang J, Wang Y, Yang Y, Liu L, Zou G, Gao H, Zhuo L, Li W
Diabetes Res Clin Pract 2019 Sep;155:107809. Epub 2019 Aug 8 doi: 10.1016/j.diabres.2019.107809. PMID: 31401150
Segmental Sclerosis and Extracapillary Hypercellularity Predict Diabetic ESRD.
Mottl AK, Gasim A, Schober FP, Hu Y, Dunnon AK, Hogan SL, Jennette JC
J Am Soc Nephrol 2018 Feb;29(2):694-703. Epub 2017 Nov 27 doi: 10.1681/ASN.2017020192. PMID: 29180393Free PMC Article

Therapy

Clinical course of Immunoglobulin A nephropathy with crescents in a multi-ethnic Southeast Asian cohort.
Lim CC, Baikunje S, Choo JCJ, Tan PH, Foo M, Woo KT
Nephrology (Carlton) 2020 Sep;25(9):708-713. Epub 2020 Jun 8 doi: 10.1111/nep.13723. PMID: 32400945
Renal injury following long-term exposure to carbon disulfide: analysis of a case series.
Yan Y, Wang C, Zheng Z, Qu L, Zeng D, Li M
BMC Nephrol 2019 Oct 17;20(1):377. doi: 10.1186/s12882-019-1553-1. PMID: 31623563Free PMC Article
Collapsing Glomerulopathy in Lambda Light Chain Amyloidosis: A Report of 2 Cases.
Khalighi MA, Gallan AJ, Chang A, Meehan SM
Am J Kidney Dis 2018 Oct;72(4):612-616. Epub 2018 Jun 19 doi: 10.1053/j.ajkd.2018.04.009. PMID: 29908693
IgA nephropathy: an update.
Soares MF, Roberts IS
Curr Opin Nephrol Hypertens 2017 May;26(3):165-171. doi: 10.1097/MNH.0000000000000312. PMID: 28221174
Methylprednisolone pulse therapy in the treatment of severe forms of Schönlein-Henoch purpura nephritis.
Niaudet P, Habib R
Pediatr Nephrol 1998 Apr;12(3):238-43. doi: 10.1007/s004670050446. PMID: 9630046

Prognosis

Clinicopathological features and outcomes of diabetic kidney disease with extracapillary hypercellularity: a Japanese single-center experience.
Saito A, Komatsuda A, Saito M, Kaga H, Abe F, Sawamura M, Nara M, Sato R, Wakui H, Takahashi N
Clin Exp Nephrol 2020 Jun;24(6):509-517. Epub 2020 Feb 10 doi: 10.1007/s10157-020-01859-y. PMID: 32037471
Segmental Sclerosis and Extracapillary Hypercellularity Predict Diabetic ESRD.
Mottl AK, Gasim A, Schober FP, Hu Y, Dunnon AK, Hogan SL, Jennette JC
J Am Soc Nephrol 2018 Feb;29(2):694-703. Epub 2017 Nov 27 doi: 10.1681/ASN.2017020192. PMID: 29180393Free PMC Article
IgA nephropathy: an update.
Soares MF, Roberts IS
Curr Opin Nephrol Hypertens 2017 May;26(3):165-171. doi: 10.1097/MNH.0000000000000312. PMID: 28221174
Validation study of Oxford Classification of IgA Nephropathy: the significance of extracapillary hypercellularity and mesangial IgG immunostaining.
Ştefan G, Ismail G, Stancu S, Zugravu A, Andronesi A, Mandache E, Mircescu G
Pathol Int 2016 Aug;66(8):453-9. Epub 2016 Jul 21 doi: 10.1111/pin.12442. PMID: 27439692
Morphologic variants of focal segmental glomerulosclerosis and their significance.
Stokes MB, D'Agati VD
Adv Chronic Kidney Dis 2014 Sep;21(5):400-7. doi: 10.1053/j.ackd.2014.02.010. PMID: 25168828

Clinical prediction guides

Clinicopathological features and outcomes of diabetic kidney disease with extracapillary hypercellularity: a Japanese single-center experience.
Saito A, Komatsuda A, Saito M, Kaga H, Abe F, Sawamura M, Nara M, Sato R, Wakui H, Takahashi N
Clin Exp Nephrol 2020 Jun;24(6):509-517. Epub 2020 Feb 10 doi: 10.1007/s10157-020-01859-y. PMID: 32037471
Prognostic nomogram and score to predict renal survival of patients with biopsy-proven diabetic nephropathy.
Jiang S, Yu T, Zhang Z, Fang J, Wang Y, Yang Y, Liu L, Zou G, Gao H, Zhuo L, Li W
Diabetes Res Clin Pract 2019 Sep;155:107809. Epub 2019 Aug 8 doi: 10.1016/j.diabres.2019.107809. PMID: 31401150
Segmental Sclerosis and Extracapillary Hypercellularity Predict Diabetic ESRD.
Mottl AK, Gasim A, Schober FP, Hu Y, Dunnon AK, Hogan SL, Jennette JC
J Am Soc Nephrol 2018 Feb;29(2):694-703. Epub 2017 Nov 27 doi: 10.1681/ASN.2017020192. PMID: 29180393Free PMC Article
IgA nephropathy: an update.
Soares MF, Roberts IS
Curr Opin Nephrol Hypertens 2017 May;26(3):165-171. doi: 10.1097/MNH.0000000000000312. PMID: 28221174
Validation study of Oxford Classification of IgA Nephropathy: the significance of extracapillary hypercellularity and mesangial IgG immunostaining.
Ştefan G, Ismail G, Stancu S, Zugravu A, Andronesi A, Mandache E, Mircescu G
Pathol Int 2016 Aug;66(8):453-9. Epub 2016 Jul 21 doi: 10.1111/pin.12442. PMID: 27439692

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