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Abnormal circulating apolipoprotein concentration

MedGen UID:
1369272
•Concept ID:
C4476649
•
Finding
Synonym: Abnormal apolipoprotein level
 
HPO: HP:0025201

Definition

A deviation from the normal concentration in blood of an apolipoprotein, i.e., of a protein that binds lipids to form lipoprotein and is thereby responsible for the transport of lipids in the blood and lymph circulation. [from HPO]

Professional guidelines

PubMed

Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice.
Mishra M, Muthuramu I, Aboumsallem JP, Kempen H, De Geest B
Int J Mol Sci 2018 Oct 30;19(11) doi: 10.3390/ijms19113399. PMID: 30380754Free PMC Article
Effects of treatment of secondary hyperparathyroidism on the lipid profile in patients on hemodialysis.
Lim PS, Hung TS, Yeh CH, Yu MH
Blood Purif 1998;16(1):22-9. doi: 10.1159/000014309. PMID: 9513759

Recent clinical studies

Etiology

Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease.
Amaya-Garrido A, Brunet M, Buffin-Meyer B, Piedrafita A, Grzesiak L, Agbegbo E, Del Bello A, Ferrandiz I, Ardeleanu S, Bermudez-Lopez M, Fedou C, Camus M, Burlet-Schiltz O, Massines J, Buléon M, Feuillet G, Alves M, Neau E, Casemayou A, Breuil B, Saulnier-Blache JS, Denis C, Voelkl J, Glorieux G, Hobson S, Arefin S, Rahman A, Kublickiene K, Stenvinkel P, Bascands JL, Faguer S, Valdivielso JM, Schanstra JP, Klein J
Sci Transl Med 2023 Sep 6;15(712):eabn5939. doi: 10.1126/scitranslmed.abn5939. PMID: 37672568
Lack of association of apoE ε4 allele with insulin resistance.
Ragogna F, Lattuada G, Ruotolo G, Luzi L, Perseghin G
Acta Diabetol 2012 Feb;49(1):25-32. Epub 2011 Feb 3 doi: 10.1007/s00592-011-0255-3. PMID: 21290252
Mechanisms of hepatic chylomicron remnant clearance.
Willnow TE
Diabet Med 1997 Aug;14 Suppl 3:S75-80. doi: 10.1002/(sici)1096-9136(199708)14:3+<s75::aid-dia449>3.3.co;2-0. PMID: 9272618
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910
Recent progress in understanding apolipoprotein B.
Young SG
Circulation 1990 Nov;82(5):1574-94. doi: 10.1161/01.cir.82.5.1574. PMID: 1977530

Diagnosis

Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Lack of association of apoE ε4 allele with insulin resistance.
Ragogna F, Lattuada G, Ruotolo G, Luzi L, Perseghin G
Acta Diabetol 2012 Feb;49(1):25-32. Epub 2011 Feb 3 doi: 10.1007/s00592-011-0255-3. PMID: 21290252
Portal vein and systemic adiponectin concentrations are closely linked with hepatic glucose and lipoprotein kinetics in extremely obese subjects.
Magkos F, Fabbrini E, Patterson BW, Eagon JC, Klein S
Metabolism 2011 Nov;60(11):1641-8. Epub 2011 May 31 doi: 10.1016/j.metabol.2011.03.019. PMID: 21632078Free PMC Article
Antiphospholipid antibodies: discovery, definitions, detection and disease.
McIntyre JA, Wagenknecht DR, Faulk WP
Prog Lipid Res 2003 May;42(3):176-237. doi: 10.1016/s0163-7827(02)00048-6. PMID: 12689618

Therapy

Lack of association of apoE ε4 allele with insulin resistance.
Ragogna F, Lattuada G, Ruotolo G, Luzi L, Perseghin G
Acta Diabetol 2012 Feb;49(1):25-32. Epub 2011 Feb 3 doi: 10.1007/s00592-011-0255-3. PMID: 21290252
Antiatherogenic small, dense HDL--guardian angel of the arterial wall?
Kontush A, Chapman MJ
Nat Clin Pract Cardiovasc Med 2006 Mar;3(3):144-53. doi: 10.1038/ncpcardio0500. PMID: 16505860
Fasting and postprandial lipid abnormalities in hypopituitary women receiving conventional replacement therapy.
al-Shoumer KA, Cox KH, Hughes CL, Richmond W, Johnston DG
J Clin Endocrinol Metab 1997 Aug;82(8):2653-9. doi: 10.1210/jcem.82.8.4129. PMID: 9253349
Lipids, risk factors and ischaemic heart disease.
Castelli WP
Atherosclerosis 1996 Jul;124 Suppl:S1-9. doi: 10.1016/0021-9150(96)05851-0. PMID: 8831910
Thyroid replacement therapy and its influence on postheparin plasma lipases and apolipoprotein-B metabolism in hypothyroidism.
Packard CJ, Shepherd J, Lindsay GM, Gaw A, Taskinen MR
J Clin Endocrinol Metab 1993 May;76(5):1209-16. doi: 10.1210/jcem.76.5.8496312. PMID: 8496312

Prognosis

Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Dyslipidemia, Insulin Resistance, Ectopic Lipid Accumulation, and Vascular Function in Resistance to Thyroid Hormone β.
Moran C, McEniery CM, Schoenmakers N, Mitchell C, Sleigh A, Watson L, Lyons G, Burling K, Barker P, Chatterjee K
J Clin Endocrinol Metab 2021 Apr 23;106(5):e2005-e2014. doi: 10.1210/clinem/dgab002. PMID: 33524107Free PMC Article
Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies.
Kwong LK, Ridinger DN, Bandhauer M, Ward JH, Samlowski WE, Iverius PH, Pritchard H, Wilson DE
J Clin Endocrinol Metab 1997 May;82(5):1572-81. doi: 10.1210/jcem.82.5.3937. PMID: 9141552
HDLs containing apolipoproteins A-I and A-II (LpA-I:A-II) as markers of coronary artery disease in men with non-insulin-dependent diabetes mellitus.
Syvänne M, Kahri J, Virtanen KS, Taskinen MR
Circulation 1995 Aug 1;92(3):364-70. doi: 10.1161/01.cir.92.3.364. PMID: 7634450
Lipoprotein(a) and apolipoproteins B and A-1 in children and coronary vascular events in their grandparents.
Wilcken DE, Wang XL, Greenwood J, Lynch J
J Pediatr 1993 Oct;123(4):519-26. doi: 10.1016/s0022-3476(05)80944-8. PMID: 8410502

Clinical prediction guides

Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease.
Amaya-Garrido A, Brunet M, Buffin-Meyer B, Piedrafita A, Grzesiak L, Agbegbo E, Del Bello A, Ferrandiz I, Ardeleanu S, Bermudez-Lopez M, Fedou C, Camus M, Burlet-Schiltz O, Massines J, Buléon M, Feuillet G, Alves M, Neau E, Casemayou A, Breuil B, Saulnier-Blache JS, Denis C, Voelkl J, Glorieux G, Hobson S, Arefin S, Rahman A, Kublickiene K, Stenvinkel P, Bascands JL, Faguer S, Valdivielso JM, Schanstra JP, Klein J
Sci Transl Med 2023 Sep 6;15(712):eabn5939. doi: 10.1126/scitranslmed.abn5939. PMID: 37672568
Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis.
Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG
Hepatology 2022 Apr;75(4):968-982. Epub 2021 Dec 7 doi: 10.1002/hep.32203. PMID: 34662439Free PMC Article
Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.
Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Antiphospholipid antibodies: discovery, definitions, detection and disease.
McIntyre JA, Wagenknecht DR, Faulk WP
Prog Lipid Res 2003 May;42(3):176-237. doi: 10.1016/s0163-7827(02)00048-6. PMID: 12689618
Fasting and postprandial lipid abnormalities in hypopituitary women receiving conventional replacement therapy.
al-Shoumer KA, Cox KH, Hughes CL, Richmond W, Johnston DG
J Clin Endocrinol Metab 1997 Aug;82(8):2653-9. doi: 10.1210/jcem.82.8.4129. PMID: 9253349

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