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Pulmonary cryptococcosis

MedGen UID:
124445
•Concept ID:
C0276688
•
Disease or Syndrome
Synonym: Cryptococcal Pneumonia
SNOMED CT: Pulmonary cryptococcosis (20953001)

Definition

Fungal pneumonia caused by inhalation of particles of Cryptococcus. It usually occurs in immunocompromised patients such as persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies. It is rare in immunocompetent individuals. Signs and symptoms include fever, cough, and dyspnea. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary cryptococcosis

Professional guidelines

PubMed

Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article
Primary pulmonary cryptococcosis.
Hatcher CR Jr, Sehdeva J, Waters WC 3rd, Schulze V, Symbas P, Logan WD Jr, Abbott OA
J Thorac Cardiovasc Surg 1971 Jan;61(1):39-49. PMID: 5540461
Pulmonary cryptococcosis: special problems in diagnosis and treatment.
Bates JH
Mod Treat 1970 May;7(3):596-605. PMID: 4920807

Recent clinical studies

Etiology

Glucocorticoids, COVID-19 and Cryptococcosis.
Dos Santos WM, Rogerio AP
Antiinflamm Antiallergy Agents Med Chem 2023;22(2):67-70. doi: 10.2174/1871523022666230912142540. PMID: 37702231
A Rare Association of Chronic Pulmonary Aspergillosis and Pulmonary Cryptococcosis as an Underlying Risk Factor.
Sekiguchi WK, Albuquerque RM, Rapozo MM, Polly M, Nastri ACSS, Magri MMC, de Oliveira VF, Bernardi FDC, Sotto MN
Mycopathologia 2023 Aug;188(4):429-431. Epub 2023 Jun 30 doi: 10.1007/s11046-023-00769-3. PMID: 37389745
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Diagnosis

Pulmonary Cryptococcosis.
Dos Santos VM
Arch Iran Med 2019 Oct 1;22(10):629-630. PMID: 31679366
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article
Pulmonary cryptococcosis.
Woodring JH, Ciporkin G, Lee C, Worm B, Woolley S
Semin Roentgenol 1996 Jan;31(1):67-75. doi: 10.1016/s0037-198x(96)80041-1. PMID: 8838946

Therapy

Cutaneous and pulmonary cryptococcosis.
Markman DL, Oliveira PPB, Takano DM, Cambuim IIFN
An Bras Dermatol 2020 May-Jun;95(3):395-397. Epub 2020 Mar 18 doi: 10.1016/j.abd.2019.07.009. PMID: 32299737Free PMC Article
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Pulmonary Cryptococcosis.
Chang CC, Sorrell TC, Chen SC
Semin Respir Crit Care Med 2015 Oct;36(5):681-91. Epub 2015 Sep 23 doi: 10.1055/s-0035-1562895. PMID: 26398535
Primary pulmonary cryptococcosis.
Asadi Gharabaghi M, Allameh SF
BMJ Case Rep 2014 Apr 1;2014 doi: 10.1136/bcr-2014-203821. PMID: 24692384Free PMC Article
Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.
Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, Harrison TS, Larsen RA, Lortholary O, Nguyen MH, Pappas PG, Powderly WG, Singh N, Sobel JD, Sorrell TC
Clin Infect Dis 2010 Feb 1;50(3):291-322. doi: 10.1086/649858. PMID: 20047480Free PMC Article

Prognosis

Rituximab for treatment of pachymeningitis in granulomatosis with polyangiitis.
Patankar A, Yadav S, Balakrishnan C, Baliga S
BMJ Case Rep 2023 Jul 14;16(7) doi: 10.1136/bcr-2022-253835. PMID: 37451799Free PMC Article
Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients.
Wu HH, Chen YX, Fang SY
J Int Med Res 2020 Jun;48(6):300060520927877. doi: 10.1177/0300060520927877. PMID: 32527202Free PMC Article
Pulmonary cryptococcosis: A review of pathobiology and clinical aspects.
Setianingrum F, Rautemaa-Richardson R, Denning DW
Med Mycol 2019 Feb 1;57(2):133-150. doi: 10.1093/mmy/myy086. PMID: 30329097
Primary pulmonary cryptococcosis.
Hatcher CR Jr, Sehdeva J, Waters WC 3rd, Schulze V, Symbas P, Logan WD Jr, Abbott OA
J Thorac Cardiovasc Surg 1971 Jan;61(1):39-49. PMID: 5540461
The spectrum of pulmonary cryptococcosis.
Warr W, Bates JH, Stone A
Ann Intern Med 1968 Dec;69(6):1109-16. doi: 10.7326/0003-4819-69-6-1109. PMID: 5725729

Clinical prediction guides

Characterization of Clinical and CT Manifestations of Pulmonary Cryptococcosis with Consolidation.
Yang D, Yu L, Luo J, Shen J, Wang D, Kuang P, Fu G
Arch Iran Med 2021 Jun 1;24(6):508-511. doi: 10.34172/aim.2021.73. PMID: 34488315
Pulmonary Cryptococcosis: comparison of Cryptococcal antigen detection and radiography in Immunocompetent and Immunocompromised patients.
Min J, Huang K, Shi C, Li L, Li F, Zhu T, Deng H
BMC Infect Dis 2020 Jan 30;20(1):91. doi: 10.1186/s12879-020-4818-1. PMID: 32000709Free PMC Article
The radiology of pulmonary cryptococcosis in a tertiary medical center.
Lacomis JM, Costello P, Vilchez R, Kusne S
J Thorac Imaging 2001 Jul;16(3):139-48. doi: 10.1097/00005382-200107000-00001. PMID: 11428412
Pulmonary cryptococcosis.
Patz EF Jr, Goodman PC
J Thorac Imaging 1992 Sep;7(4):51-5. doi: 10.1097/00005382-199209000-00008. PMID: 1404545
Pulmonary cryptococcosis.
McDonnell JM, Hutchins GM
Hum Pathol 1985 Feb;16(2):121-8. doi: 10.1016/s0046-8177(85)80060-5. PMID: 3972394

Recent systematic reviews

Pulmonary cryptococcosis complicated with pulmonary aspergillosis: a series of studies and a literature review.
Wang X, Li S, Zhu M, Qiu Y, Hui Y, Li Y, Zhan Y, Wang Y, Ye F, Li Z
BMC Infect Dis 2024 Jan 16;24(1):92. doi: 10.1186/s12879-024-09014-8. PMID: 38229026Free PMC Article
Comparison of the clinical manifestations and chest CT findings of pulmonary cryptococcosis in immunocompetent and immunocompromised patients: a systematic review and meta-analysis.
Xiong C, Lu J, Chen T, Xu R
BMC Pulm Med 2022 Nov 11;22(1):415. doi: 10.1186/s12890-022-02175-9. PMID: 36369001Free PMC Article

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