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Mpox

MedGen UID:
124442
Concept ID:
C0276180
Disease or Syndrome
Synonyms: Monkeypox; Monkeypox virus infection
SNOMED CT: Monkey pox (359814004); Monkeypox (359814004); Mpox (359814004)
 
Monarch Initiative: MONDO:0002594

Definition

An infection that is caused by an Orthopoxvirus, which is transmitted by primates or rodents, and which is characterized by a prodromal syndrome of fever, chills, headache, myalgia, and lymphedema; initial symptoms are followed by a generalized papular rash that typically progresses from vesiculation through crusting over the course of two weeks. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMpox

Professional guidelines

PubMed

Lu J, Xing H, Wang C, Tang M, Wu C, Ye F, Yin L, Yang Y, Tan W, Shen L
Signal Transduct Target Ther 2023 Dec 27;8(1):458. doi: 10.1038/s41392-023-01675-2. PMID: 38148355Free PMC Article
Li P, Pachis ST, Xu G, Schraauwen R, Incitti R, de Vries AC, Bruno MJ, Peppelenbosch MP, Alam I, Raymond K, Pan Q
Nat Microbiol 2023 Nov;8(11):2067-2079. Epub 2023 Oct 12 doi: 10.1038/s41564-023-01489-6. PMID: 37828248
Beeson AM, Haston J, McCormick DW, Reynolds M, Chatham-Stephens K, McCollum AM, Godfred-Cato S
Pediatrics 2023 Feb 1;151(2) doi: 10.1542/peds.2022-060179. PMID: 36471498Free PMC Article

Recent clinical studies

Etiology

Sanchez Clemente N, Coles C, Paixao ES, Brickley EB, Whittaker E, Alfven T, Rulisa S, Agudelo Higuita N, Torpiano P, Agravat P, Thorley EV, Drysdale SB, Le Doare K, Muyembe Tamfum JJ
Lancet Glob Health 2024 Apr;12(4):e572-e588. Epub 2024 Feb 21 doi: 10.1016/S2214-109X(23)00607-1. PMID: 38401556Free PMC Article
Beeson AM, Haston J, McCormick DW, Reynolds M, Chatham-Stephens K, McCollum AM, Godfred-Cato S
Pediatrics 2023 Feb 1;151(2) doi: 10.1542/peds.2022-060179. PMID: 36471498Free PMC Article
Singhal T, Kabra SK, Lodha R
Indian J Pediatr 2022 Oct;89(10):955-960. Epub 2022 Aug 10 doi: 10.1007/s12098-022-04348-0. PMID: 35947269Free PMC Article
Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR, Steffen R
PLoS Negl Trop Dis 2022 Feb;16(2):e0010141. Epub 2022 Feb 11 doi: 10.1371/journal.pntd.0010141. PMID: 35148313Free PMC Article
Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1027-1043. Epub 2019 Apr 11 doi: 10.1016/j.idc.2019.03.001. PMID: 30981594Free PMC Article

Diagnosis

Karagoz A, Tombuloglu H, Alsaeed M, Tombuloglu G, AlRubaish AA, Mahmoud A, Smajlović S, Ćordić S, Rabaan AA, Alsuhaimi E
J Infect Public Health 2023 Apr;16(4):531-541. Epub 2023 Feb 9 doi: 10.1016/j.jiph.2023.02.003. PMID: 36801633Free PMC Article
Lim CK, Roberts J, Moso M, Liew KC, Taouk ML, Williams E, Tran T, Steinig E, Caly L, Williamson DA
J Med Virol 2023 Jan;95(1):e28429. doi: 10.1002/jmv.28429. PMID: 36571266Free PMC Article
Elsayed S, Bondy L, Hanage WP
Clin Microbiol Rev 2022 Dec 21;35(4):e0009222. Epub 2022 Nov 14 doi: 10.1128/cmr.00092-22. PMID: 36374082Free PMC Article
Huang Y, Mu L, Wang W
Signal Transduct Target Ther 2022 Nov 2;7(1):373. doi: 10.1038/s41392-022-01215-4. PMID: 36319633Free PMC Article
Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1027-1043. Epub 2019 Apr 11 doi: 10.1016/j.idc.2019.03.001. PMID: 30981594Free PMC Article

Therapy

Lu J, Xing H, Wang C, Tang M, Wu C, Ye F, Yin L, Yang Y, Tan W, Shen L
Signal Transduct Target Ther 2023 Dec 27;8(1):458. doi: 10.1038/s41392-023-01675-2. PMID: 38148355Free PMC Article
Karagoz A, Tombuloglu H, Alsaeed M, Tombuloglu G, AlRubaish AA, Mahmoud A, Smajlović S, Ćordić S, Rabaan AA, Alsuhaimi E
J Infect Public Health 2023 Apr;16(4):531-541. Epub 2023 Feb 9 doi: 10.1016/j.jiph.2023.02.003. PMID: 36801633Free PMC Article
Beeson AM, Haston J, McCormick DW, Reynolds M, Chatham-Stephens K, McCollum AM, Godfred-Cato S
Pediatrics 2023 Feb 1;151(2) doi: 10.1542/peds.2022-060179. PMID: 36471498Free PMC Article
Hatmal MM, Al-Hatamleh MAI, Olaimat AN, Ahmad S, Hasan H, Ahmad Suhaimi NA, Albakri KA, Abedalbaset Alzyoud A, Kadir R, Mohamud R
Emerg Microbes Infect 2022 Dec;11(1):2600-2631. doi: 10.1080/22221751.2022.2132882. PMID: 36263798Free PMC Article
Singhal T, Kabra SK, Lodha R
Indian J Pediatr 2022 Oct;89(10):955-960. Epub 2022 Aug 10 doi: 10.1007/s12098-022-04348-0. PMID: 35947269Free PMC Article

Prognosis

Moss B
Nat Microbiol 2024 Jun;9(6):1408-1416. Epub 2024 May 9 doi: 10.1038/s41564-024-01690-1. PMID: 38724757
Berry MT, Khan SR, Schlub TE, Notaras A, Kunasekaran M, Grulich AE, MacIntyre CR, Davenport MP, Khoury DS
Nat Commun 2024 May 8;15(1):3856. doi: 10.1038/s41467-024-48180-w. PMID: 38719852Free PMC Article
Thornhill JP, Barkati S, Walmsley S, Rockstroh J, Antinori A, Harrison LB, Palich R, Nori A, Reeves I, Habibi MS, Apea V, Boesecke C, Vandekerckhove L, Yakubovsky M, Sendagorta E, Blanco JL, Florence E, Moschese D, Maltez FM, Goorhuis A, Pourcher V, Migaud P, Noe S, Pintado C, Maggi F, Hansen AE, Hoffmann C, Lezama JI, Mussini C, Cattelan A, Makofane K, Tan D, Nozza S, Nemeth J, Klein MB, Orkin CM; SHARE-net Clinical Group
N Engl J Med 2022 Aug 25;387(8):679-691. Epub 2022 Jul 21 doi: 10.1056/NEJMoa2207323. PMID: 35866746
Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MB, Duncan CJ, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM; NHS England High Consequence Infectious Diseases (Airborne) Network
Lancet Infect Dis 2022 Aug;22(8):1153-1162. Epub 2022 May 24 doi: 10.1016/S1473-3099(22)00228-6. PMID: 35623380Free PMC Article
Weaver JR, Isaacs SN
Immunol Rev 2008 Oct;225:96-113. doi: 10.1111/j.1600-065X.2008.00691.x. PMID: 18837778Free PMC Article

Clinical prediction guides

Karagoz A, Tombuloglu H, Alsaeed M, Tombuloglu G, AlRubaish AA, Mahmoud A, Smajlović S, Ćordić S, Rabaan AA, Alsuhaimi E
J Infect Public Health 2023 Apr;16(4):531-541. Epub 2023 Feb 9 doi: 10.1016/j.jiph.2023.02.003. PMID: 36801633Free PMC Article
Letafati A, Sakhavarz T
Microb Pathog 2023 Mar;176:106027. Epub 2023 Feb 8 doi: 10.1016/j.micpath.2023.106027. PMID: 36758824Free PMC Article
Mills MG, Juergens KB, Gov JP, McCormick CJ, Sampoleo R, Kachikis A, Amory JK, Fang FC, Pérez-Osorio AC, Lieberman NAP, Greninger AL
J Clin Virol 2023 Feb;159:105373. Epub 2022 Dec 23 doi: 10.1016/j.jcv.2022.105373. PMID: 36603329Free PMC Article
Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, Osborne JC, Rampling T, Beadsworth MB, Duncan CJ, Dunning J, Fletcher TE, Hunter ER, Jacobs M, Khoo SH, Newsholme W, Porter D, Porter RJ, Ratcliffe L, Schmid ML, Semple MG, Tunbridge AJ, Wingfield T, Price NM; NHS England High Consequence Infectious Diseases (Airborne) Network
Lancet Infect Dis 2022 Aug;22(8):1153-1162. Epub 2022 May 24 doi: 10.1016/S1473-3099(22)00228-6. PMID: 35623380Free PMC Article
Weaver JR, Isaacs SN
Immunol Rev 2008 Oct;225:96-113. doi: 10.1111/j.1600-065X.2008.00691.x. PMID: 18837778Free PMC Article

Recent systematic reviews

Pischel L, Martini BA, Yu N, Cacesse D, Tracy M, Kharbanda K, Ahmed N, Patel KM, Grimshaw AA, Malik AA, Goshua G, Omer SB
Vaccine 2024 Nov 14;42(25):126053. Epub 2024 Jun 21 doi: 10.1016/j.vaccine.2024.06.021. PMID: 38906763
Berry MT, Khan SR, Schlub TE, Notaras A, Kunasekaran M, Grulich AE, MacIntyre CR, Davenport MP, Khoury DS
Nat Commun 2024 May 8;15(1):3856. doi: 10.1038/s41467-024-48180-w. PMID: 38719852Free PMC Article
Sanchez Clemente N, Coles C, Paixao ES, Brickley EB, Whittaker E, Alfven T, Rulisa S, Agudelo Higuita N, Torpiano P, Agravat P, Thorley EV, Drysdale SB, Le Doare K, Muyembe Tamfum JJ
Lancet Glob Health 2024 Apr;12(4):e572-e588. Epub 2024 Feb 21 doi: 10.1016/S2214-109X(23)00607-1. PMID: 38401556Free PMC Article
Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR, Steffen R
PLoS Negl Trop Dis 2022 Feb;16(2):e0010141. Epub 2022 Feb 11 doi: 10.1371/journal.pntd.0010141. PMID: 35148313Free PMC Article
Beer EM, Rao VB
PLoS Negl Trop Dis 2019 Oct;13(10):e0007791. Epub 2019 Oct 16 doi: 10.1371/journal.pntd.0007791. PMID: 31618206Free PMC Article

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