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Zygomycosis

MedGen UID:
12207
•Concept ID:
C0043541
•
Disease or Syndrome
Synonym: Zygomycoses
SNOMED CT: Zygomycosis (59277005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019136
Orphanet: ORPHA73263

Definition

A rare mycosis caused by ubiquitous, opportunistic fungi of the order Mucorales, characterized by tissue infarction and necrosis due to invasion of the vasculature by hyphae. The spectrum of clinical manifestations depends on the route of infection and includes rhinocerebral, pulmonary, cutaneous, gastrointestinal, renal, and disseminated forms. The disease is usually rapidly progressive and associated with high mortality. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVZygomycosis

Professional guidelines

PubMed

Are statins applicable for the prevention and treatment of zygomycosis?
Galgóczy L, Nyilasi I, Papp T, Vágvölgyi C
Clin Infect Dis 2009 Aug 1;49(3):483; author reply 484-5. doi: 10.1086/600825. PMID: 19586402
Invasive zygomycosis: update on pathogenesis, clinical manifestations, and management.
Kontoyiannis DP, Lewis RE
Infect Dis Clin North Am 2006 Sep;20(3):581-607, vi. doi: 10.1016/j.idc.2006.06.003. PMID: 16984870
Review of treatment of zygomycosis with posaconazole in a patient with acute myeloid leukemia.
Vazquez JA
Clin Adv Hematol Oncol 2005 Oct;3(10):777-8. PMID: 16258488

Recent clinical studies

Etiology

Zygomycosis: conventional laboratory diagnosis.
Lass-Flörl C
Clin Microbiol Infect 2009 Oct;15 Suppl 5:60-5. doi: 10.1111/j.1469-0691.2009.02999.x. PMID: 19754760
Cutaneous zygomycosis.
Skiada A, Petrikkos G
Clin Microbiol Infect 2009 Oct;15 Suppl 5:41-5. doi: 10.1111/j.1469-0691.2009.02979.x. PMID: 19754756
Epidemiology and outcome of zygomycosis: a review of 929 reported cases.
Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, Sein M, Sein T, Chiou CC, Chu JH, Kontoyiannis DP, Walsh TJ
Clin Infect Dis 2005 Sep 1;41(5):634-53. Epub 2005 Jul 29 doi: 10.1086/432579. PMID: 16080086
Zygomycosis.
Gonzalez CE, Rinaldi MG, Sugar AM
Infect Dis Clin North Am 2002 Dec;16(4):895-914, vi. doi: 10.1016/s0891-5520(02)00037-5. PMID: 12512186
Rhinophycomycosis.
Thakar A, Baruah P, Kumar S, Sharma MC
J Laryngol Otol 2001 Jun;115(6):493-6. doi: 10.1258/0022215011908027. PMID: 11429077

Diagnosis

Transdiaphragmatic Mucormycosis.
Koehler P, Reimer R, Wahba R, Schömig-Markiefka B, Cornely OA
Clin Infect Dis 2020 Feb 14;70(5):940-942. doi: 10.1093/cid/ciz533. PMID: 31222210
Rhinofacialentomophthoromycosis.
Menon S, Pujary K, Kudva R, Ramaswamy B
BMJ Case Rep 2018 Mar 22;2018 doi: 10.1136/bcr-2017-223608. PMID: 29572369Free PMC Article
Rhinofacial Entomophthoromycosis.
Cao C, Khader JA
N Engl J Med 2018 Mar 1;378(9):e13. doi: 10.1056/NEJMicm1709956. PMID: 29490172
Subcutaneous fungal infections.
Pang KR, Wu JJ, Huang DB, Tyring SK
Dermatol Ther 2004;17(6):523-31. doi: 10.1111/j.1396-0296.2004.04056.x. PMID: 15571502
Zygomycosis.
Gonzalez CE, Rinaldi MG, Sugar AM
Infect Dis Clin North Am 2002 Dec;16(4):895-914, vi. doi: 10.1016/s0891-5520(02)00037-5. PMID: 12512186

Therapy

Transdiaphragmatic Mucormycosis.
Koehler P, Reimer R, Wahba R, Schömig-Markiefka B, Cornely OA
Clin Infect Dis 2020 Feb 14;70(5):940-942. doi: 10.1093/cid/ciz533. PMID: 31222210
Rhinofacial Entomophthoromycosis.
Cao C, Khader JA
N Engl J Med 2018 Mar 1;378(9):e13. doi: 10.1056/NEJMicm1709956. PMID: 29490172
Pharyngeal entomophthoromycosis.
Yu WN, Chen CJ, Chen CM
J Chin Med Assoc 2014 Jun;77(6):337-40. Epub 2014 Apr 18 doi: 10.1016/j.jcma.2014.02.013. PMID: 24746408
Epidemiology and outcome of zygomycosis: a review of 929 reported cases.
Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, Sein M, Sein T, Chiou CC, Chu JH, Kontoyiannis DP, Walsh TJ
Clin Infect Dis 2005 Sep 1;41(5):634-53. Epub 2005 Jul 29 doi: 10.1086/432579. PMID: 16080086
Subcutaneous fungal infections.
Pang KR, Wu JJ, Huang DB, Tyring SK
Dermatol Ther 2004;17(6):523-31. doi: 10.1111/j.1396-0296.2004.04056.x. PMID: 15571502

Prognosis

Rhino-orbitocerebral entomophthoramycosis.
Hoogendijk CF, van Heerden WF, Pretorius E, Vismer HF, Jacobs JF
Int J Oral Maxillofac Surg 2006 Mar;35(3):277-80. Epub 2005 Nov 8 doi: 10.1016/j.ijom.2005.07.021. PMID: 16280238
Epidemiology and outcome of zygomycosis: a review of 929 reported cases.
Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, Sein M, Sein T, Chiou CC, Chu JH, Kontoyiannis DP, Walsh TJ
Clin Infect Dis 2005 Sep 1;41(5):634-53. Epub 2005 Jul 29 doi: 10.1086/432579. PMID: 16080086
Rhinophycomycosis.
Thakar A, Baruah P, Kumar S, Sharma MC
J Laryngol Otol 2001 Jun;115(6):493-6. doi: 10.1258/0022215011908027. PMID: 11429077
Zygomycosis.
Elgart ML
Dermatol Clin 1996 Jan;14(1):141-146. doi: 10.1016/s0733-8635(05)70334-x. PMID: 8821167
Systemic zygomycosis.
Benbow EW, Stoddart RW
Postgrad Med J 1986 Nov;62(733):985-96. doi: 10.1136/pgmj.62.733.985. PMID: 3306640Free PMC Article

Clinical prediction guides

Coronavirus Disease 2019-Associated Mucormycosis: Risk Factors and Mechanisms of Disease.
Narayanan S, Chua JV, Baddley JW
Clin Infect Dis 2022 Apr 9;74(7):1279-1283. doi: 10.1093/cid/ciab726. PMID: 34420052Free PMC Article
Transdiaphragmatic Mucormycosis.
Koehler P, Reimer R, Wahba R, Schömig-Markiefka B, Cornely OA
Clin Infect Dis 2020 Feb 14;70(5):940-942. doi: 10.1093/cid/ciz533. PMID: 31222210
Epidemiology of mucormycosis in Europe.
Petrikkos G, Skiada A, Drogari-Apiranthitou M
Clin Microbiol Infect 2014 Jun;20 Suppl 6:67-73. Epub 2014 Mar 6 doi: 10.1111/1469-0691.12563. PMID: 24476100
Rhinocerebral zygomycosis.
Parthiban K, Gnanaguruvelan S, Janaki C, Sentamilselvi G, Boopalraj JM
Mycoses 1998 Jan-Feb;41(1-2):51-3. doi: 10.1111/j.1439-0507.1998.tb00376.x. PMID: 9610134
Indirect enzyme-linked immunosorbent assay for zygomycosis.
Kaufman L, Turner LF, McLaughlin DW
J Clin Microbiol 1989 Sep;27(9):1979-82. doi: 10.1128/jcm.27.9.1979-1982.1989. PMID: 2674194Free PMC Article

Recent systematic reviews

Ibrutinib and tracheal mucormycosis: A case report and systematic review of literature.
Damaraju V, Agarwal R, Singh Sehgal I, Khadwal A, Bal A, Rudramurthy SM, Muthu V
J Mycol Med 2023 Aug;33(3):101414. Epub 2023 Jul 23 doi: 10.1016/j.mycmed.2023.101414. PMID: 37523991
Mucormycosis following burn injuries: A systematic review.
Dang J, Goel P, Choi KJ, Massenzio E, Landau MJ, Pham CH, Huang S, Yenikomshian HA, Spellberg B, Gillenwater TJ
Burns 2023 Feb;49(1):15-25. Epub 2022 May 13 doi: 10.1016/j.burns.2022.05.012. PMID: 35842270
Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature.
Garg D, Muthu V, Sehgal IS, Ramachandran R, Kaur H, Bhalla A, Puri GD, Chakrabarti A, Agarwal R
Mycopathologia 2021 May;186(2):289-298. Epub 2021 Feb 5 doi: 10.1007/s11046-021-00528-2. PMID: 33544266Free PMC Article
Mucormycosis in lung transplant recipients: A systematic review of the literature and a case series.
Wand O, Unterman A, Izhakian S, Fridel L, Kramer MR
Clin Transplant 2020 Feb;34(2):e13774. Epub 2020 Jan 9 doi: 10.1111/ctr.13774. PMID: 31860739
Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease.
Ramírez Soto MC, Malaga G
Int J Dermatol 2017 Oct;56(10):1037-1045. Epub 2017 Jul 3 doi: 10.1111/ijd.13665. PMID: 28670680

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