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Pertussis

MedGen UID:
12159
Concept ID:
C0043167
Disease or Syndrome
Synonym: Bordetella pertussis infection
SNOMED CT: Pertussis (27836007); Infection due to Bordetella pertussis (27836007); Whooping cough (27836007); WC - Whooping cough (27836007)
 
Monarch Initiative: MONDO:0005077
Orphanet: ORPHA1489

Definition

A rare bacterial infectious disease characterized by severe coughing paroxysms with inspiratory whooping and posttussive vomiting, caused by infection with <i>Bordetella pertussis</i>. After a variable incubation time, the clinical course progresses through a catarrhal stage with sore throat, nasal congestion, rhinorrhea, and mild progressive dry cough, a paroxysmal stage with the typical paroxysmal coughing, and finally convalescence. Disease duration is usually 2-3 months, often with milder presentation in adolescents and adults than in infants and children. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPertussis
Follow this link to review classifications for Pertussis in Orphanet.

Professional guidelines

PubMed

Kilgore PE, Salim AM, Zervos MJ, Schmitt HJ
Clin Microbiol Rev 2016 Jul;29(3):449-86. doi: 10.1128/CMR.00083-15. PMID: 27029594Free PMC Article
Albert RH
Am Fam Physician 2010 Dec 1;82(11):1345-50. PMID: 21121518
Braman SS
Chest 2006 Jan;129(1 Suppl):138S-146S. doi: 10.1378/chest.129.1_suppl.138S. PMID: 16428703

Recent clinical studies

Etiology

Guo S, Zhu Y, Guo Q, Wan C
Ann Med 2024 Dec;56(1):2352606. Epub 2024 May 10 doi: 10.1080/07853890.2024.2352606. PMID: 38728617Free PMC Article
Alghounaim M, Alsaffar Z, Alfraij A, Bin-Hasan S, Hussain E
Med Princ Pract 2022;31(4):313-321. Epub 2022 Jun 13 doi: 10.1159/000525468. PMID: 35696990Free PMC Article
Kline JM, Smith EA, Zavala A
Am Fam Physician 2021 Aug 1;104(2):186-192. PMID: 34383446
Kilgore PE, Salim AM, Zervos MJ, Schmitt HJ
Clin Microbiol Rev 2016 Jul;29(3):449-86. doi: 10.1128/CMR.00083-15. PMID: 27029594Free PMC Article
Spector TB, Maziarz EK
Med Clin North Am 2013 Jul;97(4):537-52, ix. Epub 2013 Apr 17 doi: 10.1016/j.mcna.2013.02.004. PMID: 23809713

Diagnosis

Scruggs-Wodkowski E, Malani P
JAMA 2024 Sep 24;332(12):1030. doi: 10.1001/jama.2024.9049. PMID: 39207741
Nguyen VTN, Simon L
Prim Care 2018 Sep;45(3):423-431. doi: 10.1016/j.pop.2018.05.003. PMID: 30115332
Daniels HL, Sabella C
Pediatr Rev 2018 May;39(5):247-257. doi: 10.1542/pir.2017-0229. PMID: 29716967
Nieves DJ, Heininger U
Microbiol Spectr 2016 Jun;4(3) doi: 10.1128/microbiolspec.EI10-0008-2015. PMID: 27337481
Spector TB, Maziarz EK
Med Clin North Am 2013 Jul;97(4):537-52, ix. Epub 2013 Apr 17 doi: 10.1016/j.mcna.2013.02.004. PMID: 23809713

Therapy

Boisnard F, Manson C, Serradell L, Macina D
Expert Rev Vaccines 2023 Jan-Dec;22(1):1196-1213. Epub 2023 Dec 6 doi: 10.1080/14760584.2023.2280236. PMID: 37936265
Callegaro A, Curran D, Matthews S
Pharm Stat 2020 Sep;19(5):636-645. Epub 2020 Mar 27 doi: 10.1002/pst.2020. PMID: 32220002Free PMC Article
Locht C, Mielcarek N
Expert Rev Vaccines 2014 Sep;13(9):1147-58. Epub 2014 Aug 1 doi: 10.1586/14760584.2014.942222. PMID: 25085735
Yeh SH
Expert Rev Vaccines 2005 Apr;4(2):139-45. doi: 10.1586/14760584.4.2.139. PMID: 15889985
Mastrantonio P, Giuliano M, Stefanelli P, Sofia T, De Marzi L, Tarabini G, Quarto M, Moiraghi A
Dev Biol Stand 1997;89:255-9. PMID: 9272358

Prognosis

Nordholm AC, Emborg HD, Nørgaard SK, Nygaard U, Ronayne A, Nielsen LB, Søborg B, Andersen PH, Dalby T
Euro Surveill 2024 Apr;29(14) doi: 10.2807/1560-7917.ES.2024.29.14.2400160. PMID: 38577803Free PMC Article
Benn CS, Fisker AB, Rieckmann A, Sørup S, Aaby P
Lancet Infect Dis 2020 Oct;20(10):e274-e283. Epub 2020 Jul 6 doi: 10.1016/S1473-3099(19)30742-X. PMID: 32645296
Kuchar E, Karlikowska-Skwarnik M, Han S, Nitsch-Osuch A
Adv Exp Med Biol 2016;934:77-82. doi: 10.1007/5584_2016_21. PMID: 27256351
Vernon N, Jhaveri P
J Am Osteopath Assoc 2014 Mar;114(3 Suppl 1):S13-7. doi: 10.7556/jaoa.2014.044. PMID: 24636968
Cherry JD
Pediatr Infect Dis J 2006 Apr;25(4):361-2. doi: 10.1097/01.inf.0000210478.60841.69. PMID: 16567990

Clinical prediction guides

Domenech de Cellès M, Rohani P
Nat Rev Microbiol 2024 Nov;22(11):722-735. Epub 2024 Jun 21 doi: 10.1038/s41579-024-01064-8. PMID: 38907021
Guo S, Zhu Y, Guo Q, Wan C
Ann Med 2024 Dec;56(1):2352606. Epub 2024 May 10 doi: 10.1080/07853890.2024.2352606. PMID: 38728617Free PMC Article
Alghounaim M, Alsaffar Z, Alfraij A, Bin-Hasan S, Hussain E
Med Princ Pract 2022;31(4):313-321. Epub 2022 Jun 13 doi: 10.1159/000525468. PMID: 35696990Free PMC Article
Wilkinson K, Righolt CH, Elliott LJ, Fanella S, Mahmud SM
Vaccine 2021 May 27;39(23):3120-3130. Epub 2021 Apr 30 doi: 10.1016/j.vaccine.2021.04.032. PMID: 33934917
Esposito S, Stefanelli P, Fry NK, Fedele G, He Q, Paterson P, Tan T, Knuf M, Rodrigo C, Weil Olivier C, Flanagan KL, Hung I, Lutsar I, Edwards K, O'Ryan M, Principi N; World Association of Infectious Diseases and Immunological Disorders (WAidid) and the Vaccine Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EVASG)
Front Immunol 2019;10:1344. Epub 2019 Jul 3 doi: 10.3389/fimmu.2019.01344. PMID: 31333640Free PMC Article

Recent systematic reviews

Zhu Y, Zhang W, Hu J, Luo S, Zhou Y, Tang X, Yan R, Deng X, He H
Hum Vaccin Immunother 2024 Dec 31;20(1):2341454. Epub 2024 May 2 doi: 10.1080/21645515.2024.2341454. PMID: 38695296Free PMC Article
O'Grady NP, Alexander E, Alhazzani W, Alshamsi F, Cuellar-Rodriguez J, Jefferson BK, Kalil AC, Pastores SM, Patel R, van Duin D, Weber DJ, Deresinski S
Crit Care Med 2023 Nov 1;51(11):1570-1586. Epub 2023 Oct 12 doi: 10.1097/CCM.0000000000006022. PMID: 37902340
Wilkinson K, Righolt CH, Elliott LJ, Fanella S, Mahmud SM
Vaccine 2021 May 27;39(23):3120-3130. Epub 2021 Apr 30 doi: 10.1016/j.vaccine.2021.04.032. PMID: 33934917
Jarrett C, Wilson R, O'Leary M, Eckersberger E, Larson HJ; SAGE Working Group on Vaccine Hesitancy
Vaccine 2015 Aug 14;33(34):4180-90. Epub 2015 Apr 18 doi: 10.1016/j.vaccine.2015.04.040. PMID: 25896377
Kramer A, Schwebke I, Kampf G
BMC Infect Dis 2006 Aug 16;6:130. doi: 10.1186/1471-2334-6-130. PMID: 16914034Free PMC Article

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