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Hepatic tuberculosis

MedGen UID:
11944
•Concept ID:
C0041313
•
Disease or Syndrome
Synonyms: Hepatic Tuberculoses; Hepatic Tuberculosis; Tuberculoses, Hepatic; Tuberculosis, Hepatic
SNOMED CT: Tuberculosis of liver (186273003)
 
Monarch Initiative: MONDO:0005787

Definition

Infection of the liver with species of mycobacterium, most often mycobacterium tuberculosis. It is characterized by localized small tuberculous miliary lesions or tumor-like mass (tuberculoma), and abnormalities in liver function tests. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatic tuberculosis

Professional guidelines

PubMed

Diagnosis and treatment of congenital tuberculosis: a systematic review of 92 cases.
Li C, Liu L, Tao Y
Orphanet J Rare Dis 2019 Jun 10;14(1):131. doi: 10.1186/s13023-019-1101-x. PMID: 31182120Free PMC Article
Tuberculosis and liver disease: management issues.
Sonika U, Kar P
Trop Gastroenterol 2012 Apr-Jun;33(2):102-6. doi: 10.7869/tg.2012.25. PMID: 23025055
Treatment of congenital tuberculosis.
Patel S, DeSantis ER
Am J Health Syst Pharm 2008 Nov 1;65(21):2027-31. doi: 10.2146/ajhp080054. PMID: 18945861

Recent clinical studies

Etiology

Hepatic tuberculosis masquerading as malignancy.
Kale A, Patil PS, Chhanchure U, Deodhar K, Kulkarni S, Mehta S, Tandon S
Hepatol Int 2022 Apr;16(2):463-472. Epub 2021 Oct 23 doi: 10.1007/s12072-021-10257-9. PMID: 34687434
Extrapulmonary involvement in pediatric tuberculosis.
Kritsaneepaiboon S, Andres MM, Tatco VR, Lim CCQ, Concepcion NDP
Pediatr Radiol 2017 Sep;47(10):1249-1259. Epub 2017 Aug 29 doi: 10.1007/s00247-017-3867-0. PMID: 29052770
The impersonator.
Lode H, Wagner J, Scherübl H
Am J Med 2007 Mar;120(3):239-41. doi: 10.1016/j.amjmed.2007.01.019. PMID: 17349446
Tuberculosis transmitted through transplantation.
Graham JC, Kearns AM, Magee JG, El-Sheikh MF, Hudson M, Manas D, Gould FK, Orr KE, Freeman R
J Infect 2001 Nov;43(4):251-4. doi: 10.1053/jinf.2000.0879. PMID: 11869064
Miliary tuberculosis.
Gelb AF, Leffler C, Brewin A, Mascatello V, Lyons HA
Am Rev Respir Dis 1973 Dec;108(6):1327-33. doi: 10.1164/arrd.1973.108.6.1327. PMID: 4201630

Diagnosis

Common and uncommon imaging features of abdominal tuberculosis.
Gupta P, Kumar S, Sharma V, Mandavdhare H, Dhaka N, Sinha SK, Dutta U, Kochhar R
J Med Imaging Radiat Oncol 2019 Jun;63(3):329-339. Epub 2019 Apr 1 doi: 10.1111/1754-9485.12874. PMID: 30932343
Diagnosis and management of intra-abdominal tuberculosis.
Roberts S, Newsholme W, Gibson T
Br J Hosp Med (Lond) 2018 Jun 2;79(6):C86-C89. doi: 10.12968/hmed.2018.79.6.C86. PMID: 29894250
Imaging of abdominal tuberculosis.
Akhan O, Pringot J
Eur Radiol 2002 Feb;12(2):312-23. Epub 2001 Jul 7 doi: 10.1007/s003300100994. PMID: 11870428
Tuberculous liver abscess.
Spiegel CT, Tuazon CU
Tubercle 1984 Jun;65(2):127-31. doi: 10.1016/0041-3879(84)90065-5. PMID: 6464195
Gastrointestinal tuberculosis.
Thoeni RF, Margulis AR
Semin Roentgenol 1979 Oct;14(4):283-94. doi: 10.1016/0037-198x(79)90025-7. PMID: 386522

Therapy

A case of hepatic tuberculosis: A tuberculoma.
Khanijo S, Tandon P
Indian J Tuberc 2018 Jan;65(1):91-93. Epub 2017 Aug 12 doi: 10.1016/j.ijtb.2017.08.009. PMID: 29332659
Primary/local hepatic tuberculosis without dissemination.
Meena M, Dixit R, Meena LP, Samaria JK
BMJ Case Rep 2015 Jan 27;2015 doi: 10.1136/bcr-2014-206974. PMID: 25628318Free PMC Article
Primary tuberculoma of the liver: a case report and literature review.
Kharrasse G, Soufi M, Berekhli H, Intissar H, Bouziane M, Ismaili Z
Pan Afr Med J 2014;19:321. Epub 2014 Nov 26 doi: 10.11604/pamj.2014.19.321.5107. PMID: 25918561Free PMC Article
Isolated hepatic tuberculosis.
Jayakumar J
Kathmandu Univ Med J (KUMJ) 2008 Jul-Sep;6(23):391-2. doi: 10.3126/kumj.v6i3.1721. PMID: 20071827
The impersonator.
Lode H, Wagner J, Scherübl H
Am J Med 2007 Mar;120(3):239-41. doi: 10.1016/j.amjmed.2007.01.019. PMID: 17349446

Prognosis

Renal transplantation in a patient with chronic granulomatous disease: case report.
Caliskan B, Yazici H, Gulluoglu M, Caliskan Y, Turkmen A, Sever MS
Transplant Proc 2015 Jan-Feb;47(1):158-60. Epub 2014 Dec 2 doi: 10.1016/j.transproceed.2014.07.069. PMID: 25480525
The impersonator.
Lode H, Wagner J, Scherübl H
Am J Med 2007 Mar;120(3):239-41. doi: 10.1016/j.amjmed.2007.01.019. PMID: 17349446
Hepatobiliary tuberculosis.
Alvarez SZ
J Gastroenterol Hepatol 1998 Aug;13(8):833-9. doi: 10.1111/j.1440-1746.1998.tb00743.x. PMID: 9736180
The renaissance of abdominal tuberculosis.
Jayanthi V, Probert CS, Sher KS, Wicks AC, Mayberry JF
Dig Dis 1993;11(1):36-44. doi: 10.1159/000171399. PMID: 8443955
Tuberculous liver abscess.
Spiegel CT, Tuazon CU
Tubercle 1984 Jun;65(2):127-31. doi: 10.1016/0041-3879(84)90065-5. PMID: 6464195

Clinical prediction guides

Hepatic tuberculosis masquerading as malignancy.
Kale A, Patil PS, Chhanchure U, Deodhar K, Kulkarni S, Mehta S, Tandon S
Hepatol Int 2022 Apr;16(2):463-472. Epub 2021 Oct 23 doi: 10.1007/s12072-021-10257-9. PMID: 34687434
Multidrug-resistant tubercular liver abscess in β-thalassemia.
Agrawal A, Shrivastava J, Singh A
Indian Pediatr 2014 May;51(5):401-2. PMID: 24953587
Congenital tuberculosis.
Foo AL, Tan KK, Chay OM
Tuber Lung Dis 1993 Feb;74(1):59-61. doi: 10.1016/0962-8479(93)90070-E. PMID: 8495020
Periportal tuberculous adenitis: CT features.
Mathieu D, Ladeb MF, Guigui B, Rousseau M, Vasile N
Radiology 1986 Dec;161(3):713-5. doi: 10.1148/radiology.161.3.3786720. PMID: 3786720
Peritoneal tuberculosis.
Jorge AD
Endoscopy 1984 Jan;16(1):10-2. doi: 10.1055/s-2007-1018516. PMID: 6230225

Recent systematic reviews

Appropriate chemopreventive strategy for anti-tubercular therapy related liver injury is unsettled: Results from a systematic review and network meta-analysis.
Singh AK, Verma S, Kumar-M P, Soni H, Sharma S, Sharma S, Patil A, Sharma V
Expert Rev Clin Pharmacol 2020 Nov;13(11):1253-1262. Epub 2020 Oct 27 doi: 10.1080/17512433.2020.1835468. PMID: 33043729
Diagnosis and treatment of congenital tuberculosis: a systematic review of 92 cases.
Li C, Liu L, Tao Y
Orphanet J Rare Dis 2019 Jun 10;14(1):131. doi: 10.1186/s13023-019-1101-x. PMID: 31182120Free PMC Article
A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection.
Hickey AJ, Gounder L, Moosa MY, Drain PK
BMC Infect Dis 2015 May 6;15:209. doi: 10.1186/s12879-015-0944-6. PMID: 25943103Free PMC Article

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