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Schizophreniform disorder

MedGen UID:
11336
•Concept ID:
C0036358
•
Mental or Behavioral Dysfunction
Synonyms: Disorder, Schizophreniform; Disorders, Schizophreniform; Schizophreniform Disorder; Schizophreniform Disorders
SNOMED CT: Schizophreniform disorder (88975006)
 
Monarch Initiative: MONDO:0001265

Definition

A disorder that differs from schizophrenia specifically in total duration (schizophreniform disorder lasts at least 1 month but less than 6 months whereas schizophrenia lasts at least 6 months); schizophreniform disorder also typically causes less impairment in the individual''s social and occupational functioning. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSchizophreniform disorder

Professional guidelines

PubMed

A Brief History and the Use of PET in the Diagnosis and Management of Schizophrenia: An Educational Review.
Singh SB, Bhattarai Y, Kafle R, Panta M, Tiwari A, Ayubcha C, Werner TJ, Alavi A, Revheim ME
PET Clin 2025 Jan;20(1):11-24. Epub 2024 Oct 29 doi: 10.1016/j.cpet.2024.09.005. PMID: 39477720
Anesthesia Management of Special Patient Populations Undergoing Electroconvulsive Therapy: A Review.
Wajima Z
J Nippon Med Sch 2019;86(2):70-80. doi: 10.1272/jnms.JNMS.2019_86-202. PMID: 31130568
Antipsychotic drug treatment for elderly people with late-onset schizophrenia.
Arunpongpaisal S, Ahmed I, Aqeel N, Suchat P
Cochrane Database Syst Rev 2003;(2):CD004162. doi: 10.1002/14651858.CD004162. PMID: 12804499

Recent clinical studies

Etiology

Remission in patients with first-episode schizophrenia receiving assured antipsychotic medication: a study with risperidone long-acting injection.
Emsley R, Oosthuizen P, Koen L, Niehaus DJ, Medori R, Rabinowitz J
Int Clin Psychopharmacol 2008 Nov;23(6):325-31. doi: 10.1097/YIC.0b013e32830c2042. PMID: 18854720
Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial.
Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE; EUFEST study group
Lancet 2008 Mar 29;371(9618):1085-97. doi: 10.1016/S0140-6736(08)60486-9. PMID: 18374841
Direct costs of schizophrenia and related disorders in Italian community mental health services: a multicenter, prospective 1-year followup study.
Garattini L, Barbui C, Clemente R, Cornago D, Parazzini F; Study Group SCORE
Schizophr Bull 2004;30(2):295-302. doi: 10.1093/oxfordjournals.schbul.a007079. PMID: 15279047
Insomnia as a predictor for symptom worsening following antipsychotic withdrawal in schizophrenia.
Chemerinski E, Ho BC, Flaum M, Arndt S, Fleming F, Andreasen NC
Compr Psychiatry 2002 Sep-Oct;43(5):393-6. doi: 10.1053/comp.2002.34627. PMID: 12216015
Schizophreniform disorder: a 1-year follow-up study.
Casacchia M, de Cataldo S, Roncone R, Marcelli G
Psychopathology 1996;29(2):104-8. doi: 10.1159/000284978. PMID: 8861514

Diagnosis

A Brief History and the Use of PET in the Diagnosis and Management of Schizophrenia: An Educational Review.
Singh SB, Bhattarai Y, Kafle R, Panta M, Tiwari A, Ayubcha C, Werner TJ, Alavi A, Revheim ME
PET Clin 2025 Jan;20(1):11-24. Epub 2024 Oct 29 doi: 10.1016/j.cpet.2024.09.005. PMID: 39477720
Catatonia in DSM-5.
Tandon R, Heckers S, Bustillo J, Barch DM, Gaebel W, Gur RE, Malaspina D, Owen MJ, Schultz S, Tsuang M, van Os J, Carpenter W
Schizophr Res 2013 Oct;150(1):26-30. Epub 2013 Jun 24 doi: 10.1016/j.schres.2013.04.034. PMID: 23806583
Hypothermia and rhabdomyolysis following olanzapine injection in an adolescent with schizophreniform disorder.
Hung CF, Huang TY, Lin PY
Gen Hosp Psychiatry 2009 Jul-Aug;31(4):376-8. Epub 2008 Oct 18 doi: 10.1016/j.genhosppsych.2008.09.009. PMID: 19555799
Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial.
Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE; EUFEST study group
Lancet 2008 Mar 29;371(9618):1085-97. doi: 10.1016/S0140-6736(08)60486-9. PMID: 18374841
Schizophreniform disorder: a 1-year follow-up study.
Casacchia M, de Cataldo S, Roncone R, Marcelli G
Psychopathology 1996;29(2):104-8. doi: 10.1159/000284978. PMID: 8861514

Therapy

Hypothermia and rhabdomyolysis following olanzapine injection in an adolescent with schizophreniform disorder.
Hung CF, Huang TY, Lin PY
Gen Hosp Psychiatry 2009 Jul-Aug;31(4):376-8. Epub 2008 Oct 18 doi: 10.1016/j.genhosppsych.2008.09.009. PMID: 19555799
Remission in patients with first-episode schizophrenia receiving assured antipsychotic medication: a study with risperidone long-acting injection.
Emsley R, Oosthuizen P, Koen L, Niehaus DJ, Medori R, Rabinowitz J
Int Clin Psychopharmacol 2008 Nov;23(6):325-31. doi: 10.1097/YIC.0b013e32830c2042. PMID: 18854720
Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial.
Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP, Gheorghe MD, Rybakowski JK, Galderisi S, Libiger J, Hummer M, Dollfus S, López-Ibor JJ, Hranov LG, Gaebel W, Peuskens J, Lindefors N, Riecher-Rössler A, Grobbee DE; EUFEST study group
Lancet 2008 Mar 29;371(9618):1085-97. doi: 10.1016/S0140-6736(08)60486-9. PMID: 18374841
The association of weight gain and olanzapine plasma concentrations.
Perry PJ, Argo TR, Carnahan RM, Lund BC, Holman TL, Ellingrod VL, Miller D
J Clin Psychopharmacol 2005 Jun;25(3):250-4. doi: 10.1097/01.jcp.0000162800.64378.82. PMID: 15876904
Insomnia as a predictor for symptom worsening following antipsychotic withdrawal in schizophrenia.
Chemerinski E, Ho BC, Flaum M, Arndt S, Fleming F, Andreasen NC
Compr Psychiatry 2002 Sep-Oct;43(5):393-6. doi: 10.1053/comp.2002.34627. PMID: 12216015

Prognosis

A Brief History and the Use of PET in the Diagnosis and Management of Schizophrenia: An Educational Review.
Singh SB, Bhattarai Y, Kafle R, Panta M, Tiwari A, Ayubcha C, Werner TJ, Alavi A, Revheim ME
PET Clin 2025 Jan;20(1):11-24. Epub 2024 Oct 29 doi: 10.1016/j.cpet.2024.09.005. PMID: 39477720
Remission in patients with first-episode schizophrenia receiving assured antipsychotic medication: a study with risperidone long-acting injection.
Emsley R, Oosthuizen P, Koen L, Niehaus DJ, Medori R, Rabinowitz J
Int Clin Psychopharmacol 2008 Nov;23(6):325-31. doi: 10.1097/YIC.0b013e32830c2042. PMID: 18854720
Direct costs of schizophrenia and related disorders in Italian community mental health services: a multicenter, prospective 1-year followup study.
Garattini L, Barbui C, Clemente R, Cornago D, Parazzini F; Study Group SCORE
Schizophr Bull 2004;30(2):295-302. doi: 10.1093/oxfordjournals.schbul.a007079. PMID: 15279047
Insomnia as a predictor for symptom worsening following antipsychotic withdrawal in schizophrenia.
Chemerinski E, Ho BC, Flaum M, Arndt S, Fleming F, Andreasen NC
Compr Psychiatry 2002 Sep-Oct;43(5):393-6. doi: 10.1053/comp.2002.34627. PMID: 12216015
Schizophreniform disorder: a 1-year follow-up study.
Casacchia M, de Cataldo S, Roncone R, Marcelli G
Psychopathology 1996;29(2):104-8. doi: 10.1159/000284978. PMID: 8861514

Clinical prediction guides

A Brief History and the Use of PET in the Diagnosis and Management of Schizophrenia: An Educational Review.
Singh SB, Bhattarai Y, Kafle R, Panta M, Tiwari A, Ayubcha C, Werner TJ, Alavi A, Revheim ME
PET Clin 2025 Jan;20(1):11-24. Epub 2024 Oct 29 doi: 10.1016/j.cpet.2024.09.005. PMID: 39477720
A commentary revisiting the viral hypothesis of schizophrenia: Onset of a schizophreniform disorder subsequent to SARS CoV-2 infection.
DeLisi LE
Psychiatry Res 2021 Jan;295:113573. Epub 2020 Nov 16 doi: 10.1016/j.psychres.2020.113573. PMID: 33223274
Remission in patients with first-episode schizophrenia receiving assured antipsychotic medication: a study with risperidone long-acting injection.
Emsley R, Oosthuizen P, Koen L, Niehaus DJ, Medori R, Rabinowitz J
Int Clin Psychopharmacol 2008 Nov;23(6):325-31. doi: 10.1097/YIC.0b013e32830c2042. PMID: 18854720
Direct costs of schizophrenia and related disorders in Italian community mental health services: a multicenter, prospective 1-year followup study.
Garattini L, Barbui C, Clemente R, Cornago D, Parazzini F; Study Group SCORE
Schizophr Bull 2004;30(2):295-302. doi: 10.1093/oxfordjournals.schbul.a007079. PMID: 15279047
Boundaries of schizophrenia.
Adler CM, Strakowski SM
Psychiatr Clin North Am 2003 Mar;26(1):1-23. doi: 10.1016/s0193-953x(02)00085-0. PMID: 12683257

Recent systematic reviews

The prevalence of schizophrenia and other psychotic disorders among homeless people: a systematic review and meta-analysis.
Ayano G, Tesfaw G, Shumet S
BMC Psychiatry 2019 Nov 27;19(1):370. doi: 10.1186/s12888-019-2361-7. PMID: 31775786Free PMC Article
Sex differences in event-related potential (ERP) waveforms of primary psychotic disorders: A systematic review.
Riel H, Lee JB, Fisher DJ, Tibbo PG
Int J Psychophysiol 2019 Nov;145:119-124. Epub 2019 Feb 18 doi: 10.1016/j.ijpsycho.2019.02.006. PMID: 30790596
Systematic review and meta-analysis found higher levels of behavioural problems in male left-behind children aged 6-11 years.
Qu GB, Wu W, Wang LL, Tang X, Sun YH, Li J, Wang J
Acta Paediatr 2018 Aug;107(8):1327-1334. Epub 2018 Jan 18 doi: 10.1111/apa.14199. PMID: 29280182
Asenapine versus placebo for schizophrenia.
Hay A, Byers A, Sereno M, Basra MK, Dutta S
Cochrane Database Syst Rev 2015 Nov 24;2015(11):CD011458. doi: 10.1002/14651858.CD011458.pub2. PMID: 26599405Free PMC Article
Quality assessment and comparison of evidence for electroconvulsive therapy and repetitive transcranial magnetic stimulation for schizophrenia: a systematic meta-review.
Matheson SL, Green MJ, Loo C, Carr VJ
Schizophr Res 2010 May;118(1-3):201-10. Epub 2010 Feb 1 doi: 10.1016/j.schres.2010.01.002. PMID: 20117918

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