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Dermal foam cells

MedGen UID:
1054671
•Concept ID:
CN378006
•
Finding
HPO: HP:6000859

Definition

Presence of lipid-laden macrophages (foam cells) in the inner layer of the skin (dermis). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDermal foam cells

Professional guidelines

PubMed

Polyurethane-biomacromolecule combined foam dressing containing asiaticoside: fabrication, characterization and clinical efficacy for traumatic dermal wound treatment.
Namviriyachote N, Muangman P, Chinaroonchai K, Chuntrasakul C, Ritthidej GC
Int J Biol Macromol 2020 Jan 15;143:510-520. Epub 2019 Nov 25 doi: 10.1016/j.ijbiomac.2019.10.166. PMID: 31778697

Recent clinical studies

Etiology

Degrees of macrophage-facilitated healing in aneurysm occlusion devices.
Donehoo DA, Collier CA, VandenHeuvel SN, Roy S, Solberg SC, Raghavan SA
J Biomed Mater Res B Appl Biomater 2024 Feb;112(2):e35385. doi: 10.1002/jbm.b.35385. PMID: 38345190
The use of acellular porcine dermis, hyaluronic acid and polynucleotides in the treatment of cutaneous ulcers: Single blind randomised clinical trial.
Segreto F, Carotti S, Marangi GF, Francesconi M, Scaramuzzino L, Gratteri M, Caldaria E, Morini S, Persichetti P
Int Wound J 2020 Dec;17(6):1702-1708. Epub 2020 Jul 25 doi: 10.1111/iwj.13454. PMID: 32710584Free PMC Article
Dysfunctional lipoproteins from young smokers exacerbate cellular senescence and atherogenesis with smaller particle size and severe oxidation and glycation.
Park KH, Shin DG, Cho KH
Toxicol Sci 2014 Jul;140(1):16-25. Epub 2014 May 5 doi: 10.1093/toxsci/kfu076. PMID: 24798380
Application of a drainage film reduces fibroblast ingrowth into large-pored polyurethane foam during negative-pressure wound therapy in an in vitro model.
Wiegand C, Springer S, Abel M, Wesarg F, Ruth P, Hipler UC
Wound Repair Regen 2013 Sep-Oct;21(5):697-703. Epub 2013 Aug 12 doi: 10.1111/wrr.12073. PMID: 23937617
Verruciform xanthoma in close association with isolated epidermolytic acanthoma: a case report and review of the Japanese dermatological literature.
Fukuda H, Saito R
J Dermatol 2005 Jun;32(6):464-8. doi: 10.1111/j.1346-8138.2005.tb00781.x. PMID: 16043921

Diagnosis

Dysfunctional lipoproteins from young smokers exacerbate cellular senescence and atherogenesis with smaller particle size and severe oxidation and glycation.
Park KH, Shin DG, Cho KH
Toxicol Sci 2014 Jul;140(1):16-25. Epub 2014 May 5 doi: 10.1093/toxsci/kfu076. PMID: 24798380
Verruciform xanthoma in close association with isolated epidermolytic acanthoma: a case report and review of the Japanese dermatological literature.
Fukuda H, Saito R
J Dermatol 2005 Jun;32(6):464-8. doi: 10.1111/j.1346-8138.2005.tb00781.x. PMID: 16043921
Xanthogranulomas with inconspicuous foam cells and giant cells mimicking malignant melanoma: a clinical, histologic, and immunohistochemical study of three cases.
Busam KJ, Rosai J, Iversen K, Jungbluth AA
Am J Surg Pathol 2000 Jun;24(6):864-9. doi: 10.1097/00000478-200006000-00013. PMID: 10843290
Lipophagic panniculitis in re-excision specimens.
Zelickson BD, Winkelmann RK
Acta Derm Venereol 1991;71(1):59-61. PMID: 1676218
Immunohistochemical study of human xanthoma.
Kodama H, Masuda T
J Dermatol 1977 Apr;4(2):41-8. doi: 10.1111/j.1346-8138.1977.tb01009.x. PMID: 15461324

Therapy

Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis.
Heim M, Irondelle M, Duteil L, Cardot-Leccia N, Rocchi S, Passeron T, Tulic MK
Exp Dermatol 2022 Nov;31(11):1764-1778. Epub 2022 Aug 19 doi: 10.1111/exd.14657. PMID: 36054319Free PMC Article
The use of acellular porcine dermis, hyaluronic acid and polynucleotides in the treatment of cutaneous ulcers: Single blind randomised clinical trial.
Segreto F, Carotti S, Marangi GF, Francesconi M, Scaramuzzino L, Gratteri M, Caldaria E, Morini S, Persichetti P
Int Wound J 2020 Dec;17(6):1702-1708. Epub 2020 Jul 25 doi: 10.1111/iwj.13454. PMID: 32710584Free PMC Article
Dysfunctional lipoproteins from young smokers exacerbate cellular senescence and atherogenesis with smaller particle size and severe oxidation and glycation.
Park KH, Shin DG, Cho KH
Toxicol Sci 2014 Jul;140(1):16-25. Epub 2014 May 5 doi: 10.1093/toxsci/kfu076. PMID: 24798380
Toluene diisocyanate emission to air and migration to a surface from a flexible polyurethane foam.
Vangronsveld E, Berckmans S, Spence M
Ann Occup Hyg 2013 Jun;57(5):650-61. Epub 2013 May 16 doi: 10.1093/annhyg/mes105. PMID: 23680588
An unusual histologic variant of necrobiotic xanthogranuloma.
Ziemer M, Norgauer J, Simon JC, Koehler MJ
Am J Dermatopathol 2012 Apr;34(2):e22-6. doi: 10.1097/DAD.0b013e3182222aa8. PMID: 22441374

Prognosis

Verruciform xanthoma in close association with isolated epidermolytic acanthoma: a case report and review of the Japanese dermatological literature.
Fukuda H, Saito R
J Dermatol 2005 Jun;32(6):464-8. doi: 10.1111/j.1346-8138.2005.tb00781.x. PMID: 16043921
Lipidized fibrous histiocytoma: clinicopathologic analysis of 22 cases.
Iwata J, Fletcher CD
Am J Dermatopathol 2000 Apr;22(2):126-34. doi: 10.1097/00000372-200004000-00007. PMID: 10770432
Immunohistochemical study of human xanthoma.
Kodama H, Masuda T
J Dermatol 1977 Apr;4(2):41-8. doi: 10.1111/j.1346-8138.1977.tb01009.x. PMID: 15461324

Clinical prediction guides

A poly (saccharide-ester-urethane) scaffold for mammalian cell growth.
González-Torres M, Becerra-González M, Leyva-Gómez G, Lima E, González Mendoza O, Ruvalcaba-Paredes EK, Cortés H, Pineda C, Martínez-Torres A
Cell Mol Biol (Noisy-le-grand) 2021 Nov 25;67(3):113-117. doi: 10.14715/cmb/2021.67.3.15. PMID: 34933725
Polyurethane-biomacromolecule combined foam dressing containing asiaticoside: fabrication, characterization and clinical efficacy for traumatic dermal wound treatment.
Namviriyachote N, Muangman P, Chinaroonchai K, Chuntrasakul C, Ritthidej GC
Int J Biol Macromol 2020 Jan 15;143:510-520. Epub 2019 Nov 25 doi: 10.1016/j.ijbiomac.2019.10.166. PMID: 31778697
Post-surgical lipophagic panniculitis: a specific model of traumatic panniculitis and new histopathological findings.
Grassi S, Rosso R, Tomasini C, Pezzini C, Merlino M, Borroni G
G Ital Dermatol Venereol 2013 Aug;148(4):435-41. PMID: 23900165
Granulomatous slack skin.
Balus L, Bassetti F, Gentili G
Arch Dermatol 1985 Feb;121(2):250-2. PMID: 3977343
Immunohistochemical study of human xanthoma.
Kodama H, Masuda T
J Dermatol 1977 Apr;4(2):41-8. doi: 10.1111/j.1346-8138.1977.tb01009.x. PMID: 15461324

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