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Renal tubular karyomegaly

MedGen UID:
1054657
•Concept ID:
CN377025
•
Finding
HPO: HP:6000429

Definition

Marked enlargement of nuclei observed predominantly in the proximal convoluted tubule cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal tubular karyomegaly

Recent clinical studies

Diagnosis

Cellular senescence in kidney biopsies is associated with tubular dysfunction and predicts CKD progression in childhood cancer patients with karyomegalic interstitial nephropathy.
Knoppert SN, Keijzer-Veen MG, Valentijn FA, van den Heuvel-Eibrink MM, Lilien MR, van den Berg G, Haveman LM, Stokman MF, Janssens GO, van Kempen S, Broekhuizen R, Goldschmeding R, Nguyen TQ
J Pathol 2023 Dec;261(4):455-464. Epub 2023 Oct 4 doi: 10.1002/path.6202. PMID: 37792603
Heterozygous Variants in a Patient with Karyomegalic Interstitial Nephritis.
Wang H, Li K, Xiao R, Xu L, Zhen J, Wang R, Sun J
Nephron 2023;147(3-4):223-228. Epub 2022 Jul 27 doi: 10.1159/000525445. PMID: 35896079
Systemic karyomegaly with primary pulmonary presentation.
Tagliente DJ, Voss JS, Peters SG, Aubry MC, Cornell LD, Maleszewski JJ
Hum Pathol 2014 Jan;45(1):180-4. Epub 2013 Sep 16 doi: 10.1016/j.humpath.2013.07.036. PMID: 24047724
Primer: histopathology of polyomavirus-associated nephropathy in renal allografts.
Liptak P, Kemeny E, Ivanyi B
Nat Clin Pract Nephrol 2006 Nov;2(11):631-6. doi: 10.1038/ncpneph0319. PMID: 17066055

Therapy

Primer: histopathology of polyomavirus-associated nephropathy in renal allografts.
Liptak P, Kemeny E, Ivanyi B
Nat Clin Pract Nephrol 2006 Nov;2(11):631-6. doi: 10.1038/ncpneph0319. PMID: 17066055
Karyomegaly of tubular kidney cells in human chronic interstitial nephropathy in Tunisia: respective role of Ochratoxin A and possible genetic predisposition.
Hassen W, Abid-Essafi S, Achour A, Guezzah N, Zakhama A, Ellouz F, Creppy EE, Bacha H
Hum Exp Toxicol 2004 Jul;23(7):339-46. doi: 10.1191/0960327104ht458oa. PMID: 15311851
Carcinogenicity of ochratoxin A in experimental animals.
Huff JE
IARC Sci Publ 1991;(115):229-44. PMID: 1820337

Prognosis

Cellular senescence in kidney biopsies is associated with tubular dysfunction and predicts CKD progression in childhood cancer patients with karyomegalic interstitial nephropathy.
Knoppert SN, Keijzer-Veen MG, Valentijn FA, van den Heuvel-Eibrink MM, Lilien MR, van den Berg G, Haveman LM, Stokman MF, Janssens GO, van Kempen S, Broekhuizen R, Goldschmeding R, Nguyen TQ
J Pathol 2023 Dec;261(4):455-464. Epub 2023 Oct 4 doi: 10.1002/path.6202. PMID: 37792603
Systemic karyomegaly with primary pulmonary presentation.
Tagliente DJ, Voss JS, Peters SG, Aubry MC, Cornell LD, Maleszewski JJ
Hum Pathol 2014 Jan;45(1):180-4. Epub 2013 Sep 16 doi: 10.1016/j.humpath.2013.07.036. PMID: 24047724
Carcinogenicity of ochratoxin A in experimental animals.
Huff JE
IARC Sci Publ 1991;(115):229-44. PMID: 1820337

Clinical prediction guides

In vitro and in vivo induction of ochratoxin A exposure-related micronucleus formation in rat proximal tubular epithelial cells and expression profiling of chromosomal instability-related genes.
Ozawa S, Ojiro R, Tang Q, Zou X, Jin M, Yoshida T, Shibutani M
Food Chem Toxicol 2024 Mar;185:114486. Epub 2024 Feb 1 doi: 10.1016/j.fct.2024.114486. PMID: 38301995
Cellular senescence in kidney biopsies is associated with tubular dysfunction and predicts CKD progression in childhood cancer patients with karyomegalic interstitial nephropathy.
Knoppert SN, Keijzer-Veen MG, Valentijn FA, van den Heuvel-Eibrink MM, Lilien MR, van den Berg G, Haveman LM, Stokman MF, Janssens GO, van Kempen S, Broekhuizen R, Goldschmeding R, Nguyen TQ
J Pathol 2023 Dec;261(4):455-464. Epub 2023 Oct 4 doi: 10.1002/path.6202. PMID: 37792603
Primer: histopathology of polyomavirus-associated nephropathy in renal allografts.
Liptak P, Kemeny E, Ivanyi B
Nat Clin Pract Nephrol 2006 Nov;2(11):631-6. doi: 10.1038/ncpneph0319. PMID: 17066055

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