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Elevated natural killer cell count

MedGen UID:
1054022
•Concept ID:
CN377506
•
Finding
HPO: HP:6000677

Definition

The count of natural killer cells per volume of blood is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated natural killer cell count

Professional guidelines

PubMed

PD-1, PD-L1 and PD-L2 Gene Expression on T-Cells and Natural Killer Cells Declines in Conjunction with a Reduction in PD-1 Protein during the Intensive Phase of Tuberculosis Treatment.
Hassan SS, Akram M, King EC, Dockrell HM, Cliff JM
PLoS One 2015;10(9):e0137646. Epub 2015 Sep 11 doi: 10.1371/journal.pone.0137646. PMID: 26359860Free PMC Article
High circulating CD3+CD56+CD16+ natural killer-like T cell levels predict a better IVF treatment outcome.
Zhou J, Zhao X, Wang Z, Wang J, Sun H, Hu Y
J Reprod Immunol 2013 Apr;97(2):197-203. Epub 2013 Feb 27 doi: 10.1016/j.jri.2012.12.006. PMID: 23452704
Interferons in the pathogenesis and treatment of human immunodeficiency virus infection.
Poli G, Biswas P, Fauci AS
Antiviral Res 1994 Jul;24(2-3):221-33. doi: 10.1016/0166-3542(94)90069-8. PMID: 7526793

Recent clinical studies

Etiology

Natural Killer Cell Phenotypes and Clinical Outcomes in Pediatric Kidney Transplantation.
Kahan RH, Abraham N, Lee HJ, Ettenger RB, Grimm PC, Reed EF, Reeves RK, Sarwal MM, Stempora LL, Warshaw BL, Kirk AD, Martinez OM, Chambers ET
Pediatr Transplant 2024 Dec;28(8):e14877. doi: 10.1111/petr.14877. PMID: 39508125
The central role of natural killer cells in preeclampsia.
Wei X, Yang X
Front Immunol 2023;14:1009867. Epub 2023 Feb 14 doi: 10.3389/fimmu.2023.1009867. PMID: 36865565Free PMC Article
Recipient T Cell Exhaustion and Successful Adoptive Transfer of Haploidentical Natural Killer Cells.
Williams RL, Cooley S, Bachanova V, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR
Biol Blood Marrow Transplant 2018 Mar;24(3):618-622. Epub 2017 Nov 29 doi: 10.1016/j.bbmt.2017.11.022. PMID: 29197679Free PMC Article
Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis.
Seshadri S, Sunkara SK
Hum Reprod Update 2014 May-Jun;20(3):429-38. Epub 2013 Nov 27 doi: 10.1093/humupd/dmt056. PMID: 24285824
Exercise immunology: practical applications.
Nieman DC
Int J Sports Med 1997 Mar;18 Suppl 1:S91-100. doi: 10.1055/s-2007-972705. PMID: 9129268

Diagnosis

The causal effect of inflammatory proteins and immune cell populations on diabetic nephropathy: evidence from Mendelian randomization.
Ren Y, Zhang H
Int Urol Nephrol 2024 Aug;56(8):2769-2778. Epub 2024 Mar 23 doi: 10.1007/s11255-024-04017-5. PMID: 38520496
Uterine Natural Killer Cells in the Context of Implantation: Immunohistochemical Analysis of Endometrial Samples from Women with Habitual Abortion and Recurrent Implantation Failure.
Lapides L, Klein M, Belušáková V, Csöbönyeiová M, Varga I, Babál P
Physiol Res 2022 Dec 27;71(Suppl 1):S99-S105. doi: 10.33549/physiolres.935012. PMID: 36592445Free PMC Article
Repeated cupping manipulation temporary decreases natural killer lymphocyte frequency, activity and cytotoxicity.
Dons'koi BV, Chernyshov VP, Osypchuk DV, Baksheev SM
J Integr Med 2016 May;14(3):197-202. doi: 10.1016/S2095-4964(16)60250-9. PMID: 27181126
Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis.
Seshadri S, Sunkara SK
Hum Reprod Update 2014 May-Jun;20(3):429-38. Epub 2013 Nov 27 doi: 10.1093/humupd/dmt056. PMID: 24285824
Exercise immunology: practical applications.
Nieman DC
Int J Sports Med 1997 Mar;18 Suppl 1:S91-100. doi: 10.1055/s-2007-972705. PMID: 9129268

Therapy

The causal role of circulating immunity-inflammation in preeclampsia: A Mendelian randomization.
Xue X, Guo C, Fan C, Lei D
J Clin Hypertens (Greenwich) 2024 May;26(5):474-482. Epub 2024 Mar 12 doi: 10.1111/jch.14775. PMID: 38476059Free PMC Article
Recipient T Cell Exhaustion and Successful Adoptive Transfer of Haploidentical Natural Killer Cells.
Williams RL, Cooley S, Bachanova V, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR
Biol Blood Marrow Transplant 2018 Mar;24(3):618-622. Epub 2017 Nov 29 doi: 10.1016/j.bbmt.2017.11.022. PMID: 29197679Free PMC Article
NK cell recruitment and exercise: Potential immunotherapeutic role of shear stress and endothelial health.
Evans W
Med Hypotheses 2017 Nov;109:170-173. Epub 2017 Oct 17 doi: 10.1016/j.mehy.2017.10.015. PMID: 29150280
The role of gamma delta T cells in haematopoietic stem cell transplantation.
Minculescu L, Sengeløv H
Scand J Immunol 2015 Jun;81(6):459-68. doi: 10.1111/sji.12289. PMID: 25753378
beta-Endorphin and natural killer cell cytolytic activity during prolonged exercise. is there a connection?
Gannon GA, Rhind SG, Suzui M, Zamecnik J, Sabiston BH, Shek PN, Shephard RJ
Am J Physiol 1998 Dec;275(6):R1725-34. doi: 10.1152/ajpregu.1998.275.6.R1725. PMID: 9843861

Prognosis

The Innate Immune System and Cardiovascular Disease in ESKD: Monocytes and Natural Killer Cells.
Dounousi E, Duni A, Naka KK, Vartholomatos G, Zoccali C
Curr Vasc Pharmacol 2021;19(1):63-76. doi: 10.2174/1570161118666200628024027. PMID: 32600233
Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis.
Huang W, Berube J, McNamara M, Saksena S, Hartman M, Arshad T, Bornheimer SJ, O'Gorman M
Cytometry A 2020 Aug;97(8):772-776. Epub 2020 Jul 18 doi: 10.1002/cyto.a.24172. PMID: 32542842Free PMC Article
Recipient T Cell Exhaustion and Successful Adoptive Transfer of Haploidentical Natural Killer Cells.
Williams RL, Cooley S, Bachanova V, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR
Biol Blood Marrow Transplant 2018 Mar;24(3):618-622. Epub 2017 Nov 29 doi: 10.1016/j.bbmt.2017.11.022. PMID: 29197679Free PMC Article
NOX2-dependent immunosuppression in chronic myelomonocytic leukemia.
Aurelius J, Hallner A, Werlenius O, Riise R, Möllgård L, Brune M, Hansson M, Martner A, Thorén FB, Hellstrand K
J Leukoc Biol 2017 Aug;102(2):459-466. Epub 2017 Mar 14 doi: 10.1189/jlb.5VMA1116-454R. PMID: 28292946
Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis.
Seshadri S, Sunkara SK
Hum Reprod Update 2014 May-Jun;20(3):429-38. Epub 2013 Nov 27 doi: 10.1093/humupd/dmt056. PMID: 24285824

Clinical prediction guides

The causal role of circulating immunity-inflammation in preeclampsia: A Mendelian randomization.
Xue X, Guo C, Fan C, Lei D
J Clin Hypertens (Greenwich) 2024 May;26(5):474-482. Epub 2024 Mar 12 doi: 10.1111/jch.14775. PMID: 38476059Free PMC Article
The Innate Immune System and Cardiovascular Disease in ESKD: Monocytes and Natural Killer Cells.
Dounousi E, Duni A, Naka KK, Vartholomatos G, Zoccali C
Curr Vasc Pharmacol 2021;19(1):63-76. doi: 10.2174/1570161118666200628024027. PMID: 32600233
Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19.
Osman M, Faridi RM, Sligl W, Shabani-Rad MT, Dharmani-Khan P, Parker A, Kalra A, Tripathi MB, Storek J, Cohen Tervaert JW, Khan FM
Blood Adv 2020 Oct 27;4(20):5035-5039. doi: 10.1182/bloodadvances.2020002650. PMID: 33075136Free PMC Article
Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis.
Huang W, Berube J, McNamara M, Saksena S, Hartman M, Arshad T, Bornheimer SJ, O'Gorman M
Cytometry A 2020 Aug;97(8):772-776. Epub 2020 Jul 18 doi: 10.1002/cyto.a.24172. PMID: 32542842Free PMC Article
Recipient T Cell Exhaustion and Successful Adoptive Transfer of Haploidentical Natural Killer Cells.
Williams RL, Cooley S, Bachanova V, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR
Biol Blood Marrow Transplant 2018 Mar;24(3):618-622. Epub 2017 Nov 29 doi: 10.1016/j.bbmt.2017.11.022. PMID: 29197679Free PMC Article

Recent systematic reviews

The Effect of Acute Physical Exercise on NK-Cell Cytolytic Activity: A Systematic Review and Meta-Analysis.
Rumpf C, Proschinger S, Schenk A, Bloch W, Lampit A, Javelle F, Zimmer P
Sports Med 2021 Mar;51(3):519-530. Epub 2021 Jan 4 doi: 10.1007/s40279-020-01402-9. PMID: 33398798Free PMC Article
The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
Akbari H, Tabrizi R, Lankarani KB, Aria H, Vakili S, Asadian F, Noroozi S, Keshavarz P, Faramarz S
Life Sci 2020 Oct 1;258:118167. Epub 2020 Jul 29 doi: 10.1016/j.lfs.2020.118167. PMID: 32735885Free PMC Article
Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis.
Seshadri S, Sunkara SK
Hum Reprod Update 2014 May-Jun;20(3):429-38. Epub 2013 Nov 27 doi: 10.1093/humupd/dmt056. PMID: 24285824

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