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Glomerular PLA2R immune-complex deposition

MedGen UID:
1052882
Concept ID:
CN377499
Finding
HPO: HP:6000669

Definition

Accumulation of immune deposits, containing auto-antibodies against the podocyte antigen M-type phospholipase A2 receptor (PLA2R) in intraglomerular locations. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular PLA2R immune-complex deposition

Professional guidelines

PubMed

Chung EYM, Wang YM, Keung K, Hu M, McCarthy H, Wong G, Kairaitis L, Bose B, Harris DCH, Alexander SI
Front Immunol 2022;13:1036249. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.1036249. PMID: 36405681Free PMC Article

Recent clinical studies

Etiology

Huang G, Liu F, Yu L, Wang J, Chen J, Mao J
Front Immunol 2022;13:962502. Epub 2022 Aug 9 doi: 10.3389/fimmu.2022.962502. PMID: 36016931Free PMC Article
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Caza TN, Hassen SI, Larsen CP
Kidney360 2020 Jun 25;1(6):491-500. Epub 2020 Apr 21 doi: 10.34067/KID.0000432020. PMID: 35368588Free PMC Article
Ronco P, Debiec H
Annu Rev Pathol 2020 Jan 24;15:287-313. Epub 2019 Oct 17 doi: 10.1146/annurev-pathol-020117-043811. PMID: 31622560
Barrett CM, Troxell ML, Larsen CP, Houghton DC
Int Urol Nephrol 2014 May;46(5):963-71. Epub 2013 Nov 12 doi: 10.1007/s11255-013-0593-x. PMID: 24217802

Diagnosis

Andeen NK, Hou J
Pediatr Dev Pathol 2024 Sep-Oct;27(5):387-410. Epub 2024 Apr 5 doi: 10.1177/10935266241237656. PMID: 38576387
Huang G, Liu F, Yu L, Wang J, Chen J, Mao J
Front Immunol 2022;13:962502. Epub 2022 Aug 9 doi: 10.3389/fimmu.2022.962502. PMID: 36016931Free PMC Article
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Caza TN, Hassen SI, Larsen CP
Kidney360 2020 Jun 25;1(6):491-500. Epub 2020 Apr 21 doi: 10.34067/KID.0000432020. PMID: 35368588Free PMC Article
Ronco P, Debiec H
Annu Rev Pathol 2020 Jan 24;15:287-313. Epub 2019 Oct 17 doi: 10.1146/annurev-pathol-020117-043811. PMID: 31622560

Therapy

Xu B, Bao Q, Shen W, Hong Q
Br J Hosp Med (Lond) 2024 Oct 30;85(10):1-13. Epub 2024 Oct 29 doi: 10.12968/hmed.2024.0338. PMID: 39475016
Chung EYM, Wang YM, Keung K, Hu M, McCarthy H, Wong G, Kairaitis L, Bose B, Harris DCH, Alexander SI
Front Immunol 2022;13:1036249. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.1036249. PMID: 36405681Free PMC Article
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Barrett CM, Troxell ML, Larsen CP, Houghton DC
Int Urol Nephrol 2014 May;46(5):963-71. Epub 2013 Nov 12 doi: 10.1007/s11255-013-0593-x. PMID: 24217802
Debiec H, Lefeu F, Kemper MJ, Niaudet P, Deschênes G, Remuzzi G, Ulinski T, Ronco P
N Engl J Med 2011 Jun 2;364(22):2101-10. doi: 10.1056/NEJMoa1013792. PMID: 21631322

Prognosis

Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Arghiani M, Zamani BH, Nazemian F, Samadi S, Afsharian MS, Habibzadeh M, Eslami S, Sabbagh MG
BMC Nephrol 2021 Apr 19;22(1):138. doi: 10.1186/s12882-021-02338-6. PMID: 33874909Free PMC Article
Truong LD, Seshan SV
Am J Physiol Renal Physiol 2015 Dec 15;309(12):F1000-2. Epub 2015 Sep 23 doi: 10.1152/ajprenal.00264.2015. PMID: 26400544
Ronco P, Debiec H
Lancet 2015 May 16;385(9981):1983-92. doi: 10.1016/S0140-6736(15)60731-0. PMID: 26090644
Barrett CM, Troxell ML, Larsen CP, Houghton DC
Int Urol Nephrol 2014 May;46(5):963-71. Epub 2013 Nov 12 doi: 10.1007/s11255-013-0593-x. PMID: 24217802

Clinical prediction guides

Jiang X, Lan L, Zhou Q, Wang H, Wang H, Chen J, Han F
Lupus Sci Med 2022 Jun;9(1) doi: 10.1136/lupus-2022-000690. PMID: 35710146Free PMC Article
Al-Othman YA, Kroneman O, Kumar S, Li W, Kanaan HD, Liu ML, Qu H, Zhang PL
Ultrastruct Pathol 2022 Jan 2;46(1):122-129. Epub 2022 Feb 2 doi: 10.1080/01913123.2022.2035876. PMID: 35109758
Ronco P, Beck L, Debiec H, Fervenza FC, Hou FF, Jha V, Sethi S, Tong A, Vivarelli M, Wetzels J
Nat Rev Dis Primers 2021 Sep 30;7(1):69. doi: 10.1038/s41572-021-00303-z. PMID: 34593809
Truong LD, Seshan SV
Am J Physiol Renal Physiol 2015 Dec 15;309(12):F1000-2. Epub 2015 Sep 23 doi: 10.1152/ajprenal.00264.2015. PMID: 26400544
Ronco P, Debiec H
Lancet 2015 May 16;385(9981):1983-92. doi: 10.1016/S0140-6736(15)60731-0. PMID: 26090644

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