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Elevated circulating vitamin B12 concentration

MedGen UID:
1052593
•Concept ID:
CN376531
•
Finding
Synonyms: Elevated plasma vitamin B12 level; Elevated serum cobalamin level; Elevated serum vitamin B12 level
 
HPO: HP:6000016

Definition

Concentration of vitamin B12 in the blood circulation above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating vitamin B12 concentration

Professional guidelines

PubMed

Metabolomics for improved treatment monitoring of phenylketonuria: urinary biomarkers for non-invasive assessment of dietary adherence and nutritional deficiencies.
Wild J , Shanmuganathan M , Hayashi M , Potter M , Britz-McKibbin P
Analyst 2019 Nov 4;144(22):6595-6608. doi: 10.1039/c9an01642b. PMID: 31608347
Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility.
Nexo E, Hoffmann-Lücke E
Am J Clin Nutr 2011 Jul;94(1):359S-365S. Epub 2011 May 18 doi: 10.3945/ajcn.111.013458. PMID: 21593496Free PMC Article

Recent clinical studies

Etiology

Intracellular processing of vitamin B(12) by MMACHC (CblC).
Hannibal L, Jacobsen DW
Vitam Horm 2022;119:275-298. Epub 2022 Mar 15 doi: 10.1016/bs.vh.2022.02.001. PMID: 35337623
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Homocysteine and renal disease.
van Guldener C, Robinson K
Semin Thromb Hemost 2000;26(3):313-24. doi: 10.1055/s-2000-8407. PMID: 11011849
Homocysteine and coronary atherosclerosis.
Mayer EL, Jacobsen DW, Robinson K
J Am Coll Cardiol 1996 Mar 1;27(3):517-27. doi: 10.1016/0735-1097(95)00508-0. PMID: 8606260

Diagnosis

Diagnostic and Therapeutic Perspectives Associated to Cobalamin-Dependent Metabolism and Transcobalamins' Synthesis in Solid Cancers.
Lacombe V, Lenaers G, Urbanski G
Nutrients 2022 May 14;14(10) doi: 10.3390/nu14102058. PMID: 35631199Free PMC Article
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Significance of elevated cobalamin (vitamin B12) levels in blood.
Ermens AA, Vlasveld LT, Lindemans J
Clin Biochem 2003 Nov;36(8):585-90. doi: 10.1016/j.clinbiochem.2003.08.004. PMID: 14636871
Staging vitamin B-12 (cobalamin) status in vegetarians.
Herbert V
Am J Clin Nutr 1994 May;59(5 Suppl):1213S-1222S. doi: 10.1093/ajcn/59.5.1213S. PMID: 8172125

Therapy

Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Effect of zinc supplementation on hemogram parameters and circulating concentrations of homocysteine, vitamin B(12), and folate in zinc-deficient children and adolescents.
Sonmez Ozkarakaya I, Celik B, Karakukcu C, Altuner Torun Y
J Trace Elem Med Biol 2021 May;65:126724. Epub 2021 Jan 23 doi: 10.1016/j.jtemb.2021.126724. PMID: 33550037
Homocysteine and renal disease.
van Guldener C, Robinson K
Semin Thromb Hemost 2000;26(3):313-24. doi: 10.1055/s-2000-8407. PMID: 11011849
Homocysteine and coronary atherosclerosis.
Mayer EL, Jacobsen DW, Robinson K
J Am Coll Cardiol 1996 Mar 1;27(3):517-27. doi: 10.1016/0735-1097(95)00508-0. PMID: 8606260
Staging vitamin B-12 (cobalamin) status in vegetarians.
Herbert V
Am J Clin Nutr 1994 May;59(5 Suppl):1213S-1222S. doi: 10.1093/ajcn/59.5.1213S. PMID: 8172125

Prognosis

Diagnostic and Therapeutic Perspectives Associated to Cobalamin-Dependent Metabolism and Transcobalamins' Synthesis in Solid Cancers.
Lacombe V, Lenaers G, Urbanski G
Nutrients 2022 May 14;14(10) doi: 10.3390/nu14102058. PMID: 35631199Free PMC Article
Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Elevated Plasma Growth and Differentiation Factor 15 Predicts Incident Anemia in Older Adults Aged 60 Years and Older.
Yamaguchi Y, Zampino M, Tanaka T, Bandinelli S, Osawa Y, Ferrucci L, Semba RD
J Gerontol A Biol Sci Med Sci 2021 Jun 14;76(7):1192-1197. doi: 10.1093/gerona/glaa324. PMID: 33367500Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Homocysteine and renal disease.
van Guldener C, Robinson K
Semin Thromb Hemost 2000;26(3):313-24. doi: 10.1055/s-2000-8407. PMID: 11011849

Clinical prediction guides

Genetically predicted circulating B vitamins in relation to digestive system cancers.
Yuan S, Carter P, Vithayathil M, Kar S, Mason AM, Burgess S, Larsson SC
Br J Cancer 2021 Jun;124(12):1997-2003. Epub 2021 Apr 9 doi: 10.1038/s41416-021-01383-0. PMID: 33837300Free PMC Article
Elevated Plasma Growth and Differentiation Factor 15 Predicts Incident Anemia in Older Adults Aged 60 Years and Older.
Yamaguchi Y, Zampino M, Tanaka T, Bandinelli S, Osawa Y, Ferrucci L, Semba RD
J Gerontol A Biol Sci Med Sci 2021 Jun 14;76(7):1192-1197. doi: 10.1093/gerona/glaa324. PMID: 33367500Free PMC Article
Homocysteine and Non-Cardiac Vascular Disease.
Katsiki N, Perez-Martinez P, Mikhailidis DP
Curr Pharm Des 2017;23(22):3224-3232. doi: 10.2174/1381612823666170317124913. PMID: 28317478
Folate, vitamin B₁₂ and total homocysteine levels in Arab adolescent subjects: reference ranges and potential determinants.
Akanji AO, Thalib L, Al-Isa AN
Nutr Metab Cardiovasc Dis 2012 Oct;22(10):900-6. Epub 2010 Dec 30 doi: 10.1016/j.numecd.2010.10.020. PMID: 21194911
Significance of elevated cobalamin (vitamin B12) levels in blood.
Ermens AA, Vlasveld LT, Lindemans J
Clin Biochem 2003 Nov;36(8):585-90. doi: 10.1016/j.clinbiochem.2003.08.004. PMID: 14636871

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