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Coronary microvascular disorder

MedGen UID:
104771
•Concept ID:
C0206064
•
Disease or Syndrome
Synonym: Coronary microvascular disease
SNOMED CT: Cardiac syndrome X (233845001); Chest pain with normal coronary angiography (233845001); Coronary small artery disease (233845001); Coronary microvascular disease (233845001); Microvascular angina (233845001)
 
Monarch Initiative: MONDO:0044875

Definition

A disorder affecting the smallest coronary arteries. Causes include atherosclerosis and arterial spasm. Chest pain is a frequently observed symptom. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCoronary microvascular disorder

Professional guidelines

PubMed

Myocardial infarction with nonobstructive coronary artery disease (MINOCA): a review of pathophysiology and management.
Cheema AN, Yanagawa B, Verma S, Bagai A, Liu S
Curr Opin Cardiol 2021 Sep 1;36(5):589-596. doi: 10.1097/HCO.0000000000000886. PMID: 34397465

Recent clinical studies

Etiology

Myocardial infarction with nonobstructive coronary artery disease (MINOCA): a review of pathophysiology and management.
Cheema AN, Yanagawa B, Verma S, Bagai A, Liu S
Curr Opin Cardiol 2021 Sep 1;36(5):589-596. doi: 10.1097/HCO.0000000000000886. PMID: 34397465
Serum Salusin-β Levels Are Correlated with Slow Coronary Flow.
Wang T, Dong AH, Cao HY
Genet Test Mol Biomarkers 2016 Jul;20(7):393-7. Epub 2016 May 26 doi: 10.1089/gtmb.2015.0243. PMID: 27227272
Sex differences in the impact of CYP2C19 polymorphisms and low-grade inflammation on coronary microvascular disorder.
Akasaka T, Hokimoto S, Sueta D, Tabata N, Sakamoto K, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Ogawa H
Am J Physiol Heart Circ Physiol 2016 Jun 1;310(11):H1494-500. Epub 2016 Mar 18 doi: 10.1152/ajpheart.00911.2015. PMID: 26993229
Acute effects of intracoronary nitroglycerin and diltiazem in coronary slow flow phenomenon.
Ozdogru I, Zencir C, Dogan A, Orscelik O, Inanc MT, Celik A, Gur M, Elbasan Z, Kalay N, Oguzhan A
J Investig Med 2013 Jan;61(1):45-9. doi: 10.2310/JIM.0b013e318279b7f6. PMID: 23222003
The coronary slow flow phenomenon--a new coronary microvascular disorder.
Beltrame JF, Limaye SB, Horowitz JD
Cardiology 2002;97(4):197-202. doi: 10.1159/000063121. PMID: 12145474

Diagnosis

Myocardial infarction with nonobstructive coronary artery disease (MINOCA): a review of pathophysiology and management.
Cheema AN, Yanagawa B, Verma S, Bagai A, Liu S
Curr Opin Cardiol 2021 Sep 1;36(5):589-596. doi: 10.1097/HCO.0000000000000886. PMID: 34397465
Sex differences in the impact of CYP2C19 polymorphisms and low-grade inflammation on coronary microvascular disorder.
Akasaka T, Hokimoto S, Sueta D, Tabata N, Sakamoto K, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Ogawa H
Am J Physiol Heart Circ Physiol 2016 Jun 1;310(11):H1494-500. Epub 2016 Mar 18 doi: 10.1152/ajpheart.00911.2015. PMID: 26993229
Acute effects of intracoronary nitroglycerin and diltiazem in coronary slow flow phenomenon.
Ozdogru I, Zencir C, Dogan A, Orscelik O, Inanc MT, Celik A, Gur M, Elbasan Z, Kalay N, Oguzhan A
J Investig Med 2013 Jan;61(1):45-9. doi: 10.2310/JIM.0b013e318279b7f6. PMID: 23222003
Clinical analysis of the risk factors of slow coronary flow.
Xia S, Deng SB, Wang Y, Xiao J, Du JL, Zhang Y, Wang XC, Li YQ, Zhao R, He L, Xiang YL, She Q
Heart Vessels 2011 Sep;26(5):480-6. Epub 2011 Jan 5 doi: 10.1007/s00380-010-0081-5. PMID: 21207039
Simvastatin may improve myocardial perfusion abnormality in slow coronary flow.
Cakmak M, Tanriverdi H, Cakmak N, Evrengul H, Cetemen S, Kuru O
Cardiology 2008;110(1):39-44. Epub 2007 Oct 10 doi: 10.1159/000109405. PMID: 17934268

Therapy

Telmisartan ameliorates vascular endothelial dysfunction in coronary slow flow phenomenon (CSFP).
Jin Z, Tan Q, Sun B
Cell Biochem Funct 2018 Jan;36(1):18-26. doi: 10.1002/cbf.3313. PMID: 29314204
Sex differences in the impact of CYP2C19 polymorphisms and low-grade inflammation on coronary microvascular disorder.
Akasaka T, Hokimoto S, Sueta D, Tabata N, Sakamoto K, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Ogawa H
Am J Physiol Heart Circ Physiol 2016 Jun 1;310(11):H1494-500. Epub 2016 Mar 18 doi: 10.1152/ajpheart.00911.2015. PMID: 26993229
Nicorandil improves myocardial function by regulating plasma nitric oxide and endothelin-1 in coronary slow flow.
Chen Z, Chen X, Li S, Huo X, Fu X, Dong X
Coron Artery Dis 2015 Mar;26(2):114-20. doi: 10.1097/MCA.0000000000000179. PMID: 25325437Free PMC Article
Acute effects of intracoronary nitroglycerin and diltiazem in coronary slow flow phenomenon.
Ozdogru I, Zencir C, Dogan A, Orscelik O, Inanc MT, Celik A, Gur M, Elbasan Z, Kalay N, Oguzhan A
J Investig Med 2013 Jan;61(1):45-9. doi: 10.2310/JIM.0b013e318279b7f6. PMID: 23222003
Simvastatin may improve myocardial perfusion abnormality in slow coronary flow.
Cakmak M, Tanriverdi H, Cakmak N, Evrengul H, Cetemen S, Kuru O
Cardiology 2008;110(1):39-44. Epub 2007 Oct 10 doi: 10.1159/000109405. PMID: 17934268

Prognosis

Serum Salusin-β Levels Are Correlated with Slow Coronary Flow.
Wang T, Dong AH, Cao HY
Genet Test Mol Biomarkers 2016 Jul;20(7):393-7. Epub 2016 May 26 doi: 10.1089/gtmb.2015.0243. PMID: 27227272
Sex differences in the impact of CYP2C19 polymorphisms and low-grade inflammation on coronary microvascular disorder.
Akasaka T, Hokimoto S, Sueta D, Tabata N, Sakamoto K, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Ogawa H
Am J Physiol Heart Circ Physiol 2016 Jun 1;310(11):H1494-500. Epub 2016 Mar 18 doi: 10.1152/ajpheart.00911.2015. PMID: 26993229
Clinical analysis of the risk factors of slow coronary flow.
Xia S, Deng SB, Wang Y, Xiao J, Du JL, Zhang Y, Wang XC, Li YQ, Zhao R, He L, Xiang YL, She Q
Heart Vessels 2011 Sep;26(5):480-6. Epub 2011 Jan 5 doi: 10.1007/s00380-010-0081-5. PMID: 21207039
Simvastatin may improve myocardial perfusion abnormality in slow coronary flow.
Cakmak M, Tanriverdi H, Cakmak N, Evrengul H, Cetemen S, Kuru O
Cardiology 2008;110(1):39-44. Epub 2007 Oct 10 doi: 10.1159/000109405. PMID: 17934268
The coronary slow flow phenomenon--a new coronary microvascular disorder.
Beltrame JF, Limaye SB, Horowitz JD
Cardiology 2002;97(4):197-202. doi: 10.1159/000063121. PMID: 12145474

Clinical prediction guides

Myocardial infarction with nonobstructive coronary artery disease (MINOCA): a review of pathophysiology and management.
Cheema AN, Yanagawa B, Verma S, Bagai A, Liu S
Curr Opin Cardiol 2021 Sep 1;36(5):589-596. doi: 10.1097/HCO.0000000000000886. PMID: 34397465
Serum Salusin-β Levels Are Correlated with Slow Coronary Flow.
Wang T, Dong AH, Cao HY
Genet Test Mol Biomarkers 2016 Jul;20(7):393-7. Epub 2016 May 26 doi: 10.1089/gtmb.2015.0243. PMID: 27227272
Sex differences in the impact of CYP2C19 polymorphisms and low-grade inflammation on coronary microvascular disorder.
Akasaka T, Hokimoto S, Sueta D, Tabata N, Sakamoto K, Yamamoto E, Yamamuro M, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Ogata Y, Ogawa H
Am J Physiol Heart Circ Physiol 2016 Jun 1;310(11):H1494-500. Epub 2016 Mar 18 doi: 10.1152/ajpheart.00911.2015. PMID: 26993229
Clinical analysis of the risk factors of slow coronary flow.
Xia S, Deng SB, Wang Y, Xiao J, Du JL, Zhang Y, Wang XC, Li YQ, Zhao R, He L, Xiang YL, She Q
Heart Vessels 2011 Sep;26(5):480-6. Epub 2011 Jan 5 doi: 10.1007/s00380-010-0081-5. PMID: 21207039
The coronary slow flow phenomenon--a new coronary microvascular disorder.
Beltrame JF, Limaye SB, Horowitz JD
Cardiology 2002;97(4):197-202. doi: 10.1159/000063121. PMID: 12145474

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