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Neoplasms, Hormone-Dependent

MedGen UID:
10218
•Concept ID:
C0027661
•
Neoplastic Process
Synonyms: Hormone Dependent Neoplasms; Hormone-Dependent Neoplasm; Hormone-Dependent Neoplasms; Neoplasm, Hormone-Dependent; Neoplasms, Hormone Dependent

Definition

Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasms, Hormone-Dependent

Professional guidelines

PubMed

Managing menopausal symptoms after cancer: an evidence-based approach for primary care.
Marino JL, McNamara HC, Hickey M
Med J Aust 2018 Feb 19;208(3):127-132. doi: 10.5694/mja17.00693. PMID: 29438648
Management of cancer treatment-induced bone loss in early breast and prostate cancer -- a consensus paper of the Belgian Bone Club.
Body JJ, Bergmann P, Boonen S, Boutsen Y, Devogelaer JP, Goemaere S, Reginster JY, Rozenberg S, Kaufman JM
Osteoporos Int 2007 Nov;18(11):1439-50. Epub 2007 Aug 10 doi: 10.1007/s00198-007-0439-4. PMID: 17690930
Treatment of breast cancer with gonadotropin-releasing hormone.
Manni A, Santen R, Harvey H, Lipton A, Max D
Endocr Rev 1986 Feb;7(1):89-94. doi: 10.1210/edrv-7-1-89. PMID: 3082618

Recent clinical studies

Etiology

Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Pharmacogenetics of aromatase inhibitors.
Hadfield KD, Newman WG
Pharmacogenomics 2012 Apr;13(6):699-707. doi: 10.2217/pgs.12.28. PMID: 22515612
Pathology of endometrioid carcinoma.
Albertini AF, Devouassoux-Shisheboran M, Genestie C
Bull Cancer 2012 Jan;99(1):7-12. doi: 10.1684/bdc.2011.1526. PMID: 22231875
Operable breast cancer.
Cianfrocca M, Goldstein LJ
Curr Treat Options Oncol 2001 Apr;2(2):157-67. doi: 10.1007/s11864-001-0058-9. PMID: 12057134
Tamoxifen and the endometrium.
Barakat RR
Cancer Treat Res 1998;94:195-207. doi: 10.1007/978-1-4615-6189-7_11. PMID: 9587689

Diagnosis

Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Chemotherapy in Prostate Cancer.
Hurwitz M
Curr Oncol Rep 2015 Oct;17(10):44. doi: 10.1007/s11912-015-0468-7. PMID: 26216506
Advanced clinical states in prostate cancer.
Cheng HH, Lin DW, Yu EY
Urol Clin North Am 2012 Nov;39(4):561-71. Epub 2012 Sep 12 doi: 10.1016/j.ucl.2012.07.011. PMID: 23084531
Drug and hormone interactions of aromatase inhibitors.
Dowsett M
Endocr Relat Cancer 1999 Jun;6(2):181-5. doi: 10.1677/erc.0.0060181. PMID: 10731107
Neurofibromatosis and cancer.
Bader JL
Ann N Y Acad Sci 1986;486:57-65. doi: 10.1111/j.1749-6632.1986.tb48062.x. PMID: 3105405

Therapy

Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer: Long-Term Survival Analysis of the Randomized Phase III E3805 CHAARTED Trial.
Kyriakopoulos CE, Chen YH, Carducci MA, Liu G, Jarrard DF, Hahn NM, Shevrin DH, Dreicer R, Hussain M, Eisenberger M, Kohli M, Plimack ER, Vogelzang NJ, Picus J, Cooney MM, Garcia JA, DiPaola RS, Sweeney CJ
J Clin Oncol 2018 Apr 10;36(11):1080-1087. Epub 2018 Jan 31 doi: 10.1200/JCO.2017.75.3657. PMID: 29384722Free PMC Article
Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis.
Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V, Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE Jr, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Minckwitz G
Lancet 2014 Jul 12;384(9938):164-72. Epub 2014 Feb 14 doi: 10.1016/S0140-6736(13)62422-8. PMID: 24529560
The role of IMiDs alone or in combination in prostate cancer.
Nabhan C, Petrylak DP
Clin Genitourin Cancer 2012 Sep;10(3):141-6. Epub 2012 May 17 doi: 10.1016/j.clgc.2012.03.005. PMID: 22608152
Triple-negative breast cancer.
Bartsch R, Ziebermayr R, Zielinski CC, Steger GG
Wien Med Wochenschr 2010 Apr;160(7-8):174-81. doi: 10.1007/s10354-010-0773-6. PMID: 20473728
Prevention of prostate cancer.
DePrimo SE, Shinghal R, Vidanes G, Brooks JD
Hematol Oncol Clin North Am 2001 Jun;15(3):445-57. doi: 10.1016/s0889-8588(05)70225-2. PMID: 11525290

Prognosis

Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Chemotherapy in Prostate Cancer.
Hurwitz M
Curr Oncol Rep 2015 Oct;17(10):44. doi: 10.1007/s11912-015-0468-7. PMID: 26216506
Maximal testosterone suppression in prostate cancer--free vs total testosterone.
Rove KO, Crawford ED, Perachino M, Morote J, Klotz L, Lange PH, Andriole GL, Matsumoto AM, Taneja SS, Eisenberger MA, Reis LO
Urology 2014 Jun;83(6):1217-22. Epub 2014 Apr 6 doi: 10.1016/j.urology.2014.02.001. PMID: 24713136Free PMC Article
The changing therapeutic landscape of castration-resistant prostate cancer.
Yap TA, Zivi A, Omlin A, de Bono JS
Nat Rev Clin Oncol 2011 Aug 9;8(10):597-610. doi: 10.1038/nrclinonc.2011.117. PMID: 21826082
Prevention of prostate cancer.
DePrimo SE, Shinghal R, Vidanes G, Brooks JD
Hematol Oncol Clin North Am 2001 Jun;15(3):445-57. doi: 10.1016/s0889-8588(05)70225-2. PMID: 11525290

Clinical prediction guides

Update on breast cancer risk prediction and prevention.
Sestak I, Cuzick J
Curr Opin Obstet Gynecol 2015 Feb;27(1):92-7. doi: 10.1097/GCO.0000000000000153. PMID: 25517358
Pharmacogenetics of aromatase inhibitors.
Hadfield KD, Newman WG
Pharmacogenomics 2012 Apr;13(6):699-707. doi: 10.2217/pgs.12.28. PMID: 22515612
Predicting response to cytotoxic drugs--the endocrine part of the story.
Sheri A, Dowsett M
Breast 2011 Oct;20 Suppl 3:S28-30. doi: 10.1016/S0960-9776(11)70290-9. PMID: 22015289
Estrogen carcinogenesis in breast cancer.
Germain D
Endocrinol Metab Clin North Am 2011 Sep;40(3):473-84, vii. Epub 2011 Jun 29 doi: 10.1016/j.ecl.2011.05.009. PMID: 21889715
MicroRNAs and prostate cancer.
Coppola V, De Maria R, Bonci D
Endocr Relat Cancer 2010 Mar;17(1):F1-17. Epub 2010 Jan 29 doi: 10.1677/ERC-09-0172. PMID: 19779034

Recent systematic reviews

Review of concepts in therapeutic decision-making in HER2-negative luminal metastatic breast cancer.
Alvarez-Lopez I, Bezares S, Dalmau Portulas E, García-Martínez E, García-Sáenz JÁ, Gil-Gil M, Martínez de Dueñas E, Ribelles N, Santaballa Bertrán A
Clin Transl Oncol 2020 Aug;22(8):1364-1377. Epub 2020 Feb 12 doi: 10.1007/s12094-019-02269-7. PMID: 32052382Free PMC Article
Gender-affirming hormone therapy and the risk of sex hormone-dependent tumours in transgender individuals-A systematic review.
McFarlane T, Zajac JD, Cheung AS
Clin Endocrinol (Oxf) 2018 Dec;89(6):700-711. Epub 2018 Sep 18 doi: 10.1111/cen.13835. PMID: 30107028
Aromatase inhibitors in premenopausal women with breast cancer: the state of the art and future prospects.
Pistelli M, Mora AD, Ballatore Z, Berardi R
Curr Oncol 2018 Apr;25(2):e168-e175. Epub 2018 Apr 30 doi: 10.3747/co.25.3735. PMID: 29719441Free PMC Article
Cardiac glycosides and breast cancer risk: A systematic review and meta-analysis of observational studies.
Karasneh RA, Murray LJ, Cardwell CR
Int J Cancer 2017 Mar 1;140(5):1035-1041. Epub 2016 Nov 27 doi: 10.1002/ijc.30520. PMID: 27861859
Systematic review on hormone receptor testing in breast cancer.
Nofech-Mozes S, Vella ET, Dhesy-Thind S, Hagerty KL, Mangu PB, Temin S, Hanna WM
Appl Immunohistochem Mol Morphol 2012 May;20(3):214-63. doi: 10.1097/PAI.0b013e318234aa12. PMID: 22505008

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