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APOE genotype
Clinical Genetic Test
Help
offered by
IBC Instituto de Bioquimica Clinica SRL
GTR Test Accession: Help GTR000552067.1
INHERITED DISEASENERVOUS SYSTEMPSYCHIATRIC ... View more
Registered in GTR: 2016-09-20
View version history
Last annual review date for the lab: 2023-07-12 Past due LinkOut
At a Glance
Test purpose: Help
Prognostic
Conditions (2): Help
Early-onset autosomal dominant Alzheimer disease; Alzheimer disease type 1
Genes (1): Help
APOE (19q13.32)
Methods (1): Help
Molecular Genetics - Targeted variant analysis: RFLP
Target population: Help
Alzheimer family patients
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
IBC Instituto de Bioquimica Clinica SRL
View lab's website
Test short name: Help
APOE
Specimen Source: Help
  • Peripheral (whole) blood
Who can order: Help
  • Health Care Provider
Test Order Code: Help
APOE genotype
Contact Policy: Help
Pre-test email/phone consultation regarding genetic test results and interpretation is provided to patients/families.
How to Order: Help
Order URL
Test service: Help
Clinical Testing/Confirmation of Mutations Identified Previously
Test additional service: Help
Custom mutation-specific/Carrier testing
Test development: Help
Test developed by laboratory but exempt from FDA oversight (eg. NYS CLEP approved, offered within a hospital or clinic)
Informed consent required: Help
Decline to answer
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Lab contact for this test, Test strategy
Conditions Help
Total conditions: 2
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 1
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument
Targeted variant analysis
RFLP
Multigene Labnet
Clinical Information
Test purpose: Help
Prognostic
Target population: Help
Alzheimer family patients
View citations (1)
  • Wolters FJ, Koudstaal PJ, Hofman A, van Duijn CM, Ikram MA. Serum apolipoprotein E is associated with long-term risk of Alzheimer's disease: The Rotterdam Study. Neurosci Lett. 2016;617:139-42. doi:10.1016/j.neulet.2016.02.018. Epub 2016 Feb 11. PMID: 26876448.
Recommended fields not provided:
Clinical validity, Clinical utility, What is the protocol for interpreting a variation as a VUS?, Are family members with defined clinical status recruited to assess significance of VUS without charge?, Will the lab re-contact the ordering physician if variant interpretation changes?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
142 patients 100% specificity
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
No
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, PT Provider, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Category: FDA exercises enforcement discretion
Additional Information

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