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PALB2 partner and localizer of BRCA2

Gene ID: 79728, updated on 10-Dec-2024
Gene type: protein coding
Also known as: FANCN; PNCA3; BROVCA5

Summary

This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]

Associated conditions

See all available tests in GTR for this gene

DescriptionTests
Breast-ovarian cancer, familial, susceptibility to, 5
MedGen: C5830615OMIM: 620442GeneReviews: Not available
not available
Fanconi anemia complementation group N
MedGen: C1835817OMIM: 610832GeneReviews: Fanconi Anemia
not available
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
GeneReviews: Not available
Hereditary cancer-predisposing syndrome
MedGen: C0027672GeneReviews: Not available
not available
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
GeneReviews: Not available
Pancreatic cancer, susceptibility to, 3
MedGen: C3150547OMIM: 613348GeneReviews: Not available
not available
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
GeneReviews: Not available

Genomic context

Location:
16p12.2
Sequence:
Chromosome: 16; NC_000016.10 (23603165..23641310, complement)
Total number of exons:
14

Links

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