FTO FTO alpha-ketoglutarate dependent dioxygenase
Gene ID: 79068, updated on 4-Jan-2025Gene type: protein coding
Also known as: GDFD; IFEX9; ALKBH9; BMIQ14
- See all available tests in GTR for this gene
- Go to complete Gene record for FTO
- Go to Variation Viewer for FTO variants
Summary
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. GeneReviews: Not available | |
| A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. GeneReviews: Not available | |
| A genome-wide association study on obesity and obesity-related traits. GeneReviews: Not available | |
| A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. GeneReviews: Not available | |
| A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. GeneReviews: Not available | |
| A variant in FTO shows association with melanoma risk not due to BMI. GeneReviews: Not available | |
| Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. GeneReviews: Not available | |
| Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. GeneReviews: Not available | |
| Body mass index quantitative trait locus 14 | See labs |
| Common body mass index-associated variants confer risk of extreme obesity. GeneReviews: Not available | |
| Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. GeneReviews: Not available | |
| Common variants near MC4R are associated with fat mass, weight and risk of obesity. GeneReviews: Not available | |
| Discovery and refinement of loci associated with lipid levels. GeneReviews: Not available | |
| EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. GeneReviews: Not available | |
| FTO genotype is associated with phenotypic variability of body mass index. GeneReviews: Not available | |
| Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. GeneReviews: Not available | |
| Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. GeneReviews: Not available | |
| Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. GeneReviews: Not available | |
| Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. GeneReviews: Not available | |
| Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. GeneReviews: Not available | |
| Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. GeneReviews: Not available | |
| Genome-wide association studies identify four ER negative-specific breast cancer risk loci. GeneReviews: Not available | |
| Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. GeneReviews: Not available | |
| Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. GeneReviews: Not available | |
| Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. GeneReviews: Not available | |
| Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women. GeneReviews: Not available | |
| Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3. GeneReviews: Not available | |
| Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. GeneReviews: Not available | |
| Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. GeneReviews: Not available | |
| Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. GeneReviews: Not available | |
| Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. GeneReviews: Not available | |
| Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. GeneReviews: Not available | |
| Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. GeneReviews: Not available | |
| Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. GeneReviews: Not available | |
| Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis. GeneReviews: Not available | |
| Large-scale genotyping identifies 41 new loci associated with breast cancer risk. GeneReviews: Not available | |
| Lethal polymalformative syndrome, Boissel type | See labs |
| Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. GeneReviews: Not available | |
| Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity. GeneReviews: Not available | |
| Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. GeneReviews: Not available | |
| NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. GeneReviews: Not available | |
| Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. GeneReviews: Not available | |
| Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. GeneReviews: Not available | |
| Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. GeneReviews: Not available | |
| Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. GeneReviews: Not available | |
| Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. GeneReviews: Not available | |
| Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. GeneReviews: Not available | |
| Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. GeneReviews: Not available | |
| Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. GeneReviews: Not available |
Genomic context
- Location:
- 16q12.2
- Sequence:
- Chromosome: 16; NC_000016.10 (53703963..54121941)
- Total number of exons:
- 17
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for FTO variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- FTO database
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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