ZIC1 Zic family member 1
Gene ID: 7545, updated on 27-Nov-2024Gene type: protein coding
Also known as: ZIC; CRS6; BAIDCS; ZNF201
- See all available tests in GTR for this gene
- Go to complete Gene record for ZIC1
- Go to Variation Viewer for ZIC1 variants
Summary
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Craniosynostosis 6 | See labs |
| Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. GeneReviews: Not available | |
| Structural brain anomalies with impaired intellectual development and craniosynostosis | See labs |
Copy number response
| Description |
|---|
| Copy number response Haploinsufficency No evidence available (Last evaluated 2021-07-19) ClinGen Genome Curation PageTriplosensitivity No evidence available (Last evaluated 2021-07-19) ClinGen Genome Curation Page |
Genomic context
- Location:
- 3q24
- Sequence:
- Chromosome: 3; NC_000003.12 (147409365..147416719)
- Total number of exons:
- 3
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for ZIC1 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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