SUOX sulfite oxidase
Gene ID: 6821, updated on 4-Jan-2025Gene type: protein coding
- See all available tests in GTR for this gene
- Go to complete Gene record for SUOX
- Go to Variation Viewer for SUOX variants
Summary
Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. GeneReviews: Not available | |
| Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population. GeneReviews: Not available | |
| Genetics of rheumatoid arthritis contributes to biology and drug discovery. GeneReviews: Not available | |
| Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. GeneReviews: Not available | |
| Sulfite oxidase deficiency | See labs |
Genomic context
- Location:
- 12q13.2
- Sequence:
- Chromosome: 12; NC_000012.12 (55997276..56005525)
- Total number of exons:
- 6
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for SUOX variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- SUOX database
- Variation ViewerRelated Variants
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