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GTR Home > Conditions/Phenotypes > Marbach-Schaaf neurodevelopmental syndrome

Summary

Marbach-Schaaf neurodevelopmental syndrom (MASNS) is characterized by global developmental delay with speech delay and behavioral abnormalities, including autism spectrum disorder and ADHD. Affected individuals also show movement disorders, such as dyspraxia and apraxia. More variable features include high pain tolerance, sleep disturbances, and variable nonspecific dysmorphic features (summary by Marbach et al., 2021). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: MASNS, PRKAR1, PRKAR1B
    Summary: protein kinase cAMP-dependent type I regulatory subunit beta

Clinical features

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