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GTR Home > Conditions/Phenotypes > Spermatogenic failure 58

Spermatogenic failure 58

Summary

Spermatogenic failure-58 (SPGF58) is characterized by male infertility due to multiple morphologic abnormalities of the flagella (MMAF). Sperm are immotile or show severely reduced progressive motility due to short and irregular caliber flagella as well as bent, coiled, and absent flagella. Head abnormalities have also been observed, including acrosomal and postacrosomal defects (Lores et al., 2021). For a general phenotypic description and discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150). [from OMIM]

Available tests

1 test is in the database for this condition.

Clinical tests (1 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: BBS22, CCDC2, CMG-1, CMG1, JBTS40, SPGF58, IFT74
    Summary: intraflagellar transport 74

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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