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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 09, 2018 |
| Title |
In vivo CRISPR screening unveils multiple epigenetic regulators as novel tumour suppressor genes in lung cancer |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
This study provides the first systematic CRIPSR screening of tumour suppressor genes (TSGs) in vivo and identifies bona fide TSGs especially for epigenetic regulators contributing to lung tumour progression. Moreover, our data provides a potential therapeutic strategy for the effective treatment of UTX-mutant lung tumours.
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| Overall design |
mRNA profiles of Kras and Kras/Utx tumors were generated by next generation sequencing
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| Contributor(s) |
Wu Q, Zhang J, Zhao H, Tong X, Tang Y, Gao L, Fang Z, Hu X, Tian Y, Li F, Qin Z, Yao S, Huang H, Ge K, Chen L, Wong K, Chen L, Ji H |
| Citation(s) |
29632194 |
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| Submission date |
Jan 09, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Hongbin Ji |
| E-mail(s) |
[email protected]
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| Organization name |
Shanghai Institute of Biochemistry and Cell Biology
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| Street address |
320 Yue Yang Road
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| City |
Shanghai |
| ZIP/Postal code |
200031 |
| Country |
China |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA360579 |
| SRA |
SRP096321 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE93302_gene_diff.txt.gz |
50.6 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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