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| Status |
Public on Nov 17, 2016 |
| Title |
mRNA expression profiling in myocardial tissue by caloric restriction initiated in different aged mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The pathway analysis of differentially expressed genes (DEGs) demonstrated that some altered pathways, such as p53, cell cycle, and TGFb signaling pathways were closely associated with cardiac aging. Notably, FOXO signaling pathway revealed significant differences between CR initiated in different aged mice
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| |
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| Overall design |
In this study, 6 samples from young, middle-aged, and old mice with or without caloric restriction (CR) were used to acquire the mRNA expression profiling thus to elucidate the possible molecular pathways underlying the observed different effects of CR on cardiac aging.
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| |
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| Contributor(s) |
Sheng Y, Huang M |
| Citation(s) |
28799249 |
| |
| Submission date |
Nov 16, 2016 |
| Last update date |
Nov 01, 2017 |
| Contact name |
yunlu sheng |
| E-mail(s) |
[email protected]
|
| Phone |
15952008286
|
| Organization name |
The First Hospital Affiliated to Nanjing Medical University
|
| Department |
Department of Gerotology
|
| Street address |
300 Guangzhou Road
|
| City |
Nanjing |
| State/province |
Jiangsu |
| ZIP/Postal code |
210029 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE89909 |
mRNA and miRNA expression profiling in myocardial tissue by caloric restriction initiated in different aged mice |
|
| Relations |
| BioProject |
PRJNA354529 |
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