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| Status |
Public on Sep 28, 2017 |
| Title |
Dietary medium-chain saturated fatty acids induce gene expression of energy metabolism-related pathways in adipose tissue of abdominally obese subjects |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
High MC-SFA intake resulted in a downregulation of gene expression of pathways related to complement system and inflammation, and an upregulation of gene expression of pathways related to citric acid cycle, electron transport chain and lipid metabolism in adipose tissue. Based on our results, we hypothesize that the beneficial effects of MC-SFAs on prevention of fat accumulation may be mediated by increases in gene expression related to energy metabolism in the adipose tissue. Additionally, decreases in inflammation-related gene expression in the adipose may potentially have beneficial effects in relation to cardiometabolic diseases.
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| Overall design |
In this 12 week, randomized, double-blind, diet intervention study, participants consumed 60 g milk protein (whey or casein) and 63 g milk fat (high MC-SFA or low MC-SFA) daily in a 2 by 2 factorial design. We used microarrays to measure whole genome gene expression in adipose tissue in a subpopulation of 12 participants, 6 in the casein + low MC-SFA group and 6 in the casein + high MC-SFA group, before and after intervention.
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| Contributor(s) |
Matualatupauw JC, Bohl M, Gregersen S, Hermansen K, Afman LA |
| Citation(s) |
28529330 |
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| Submission date |
Sep 27, 2016 |
| Last update date |
Jan 03, 2018 |
| Contact name |
Juri C Matualatupauw |
| E-mail(s) |
[email protected]
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| Organization name |
Wageningen University
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| Department |
Human Nutrition
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| Street address |
PO Box 17
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| City |
Wageningen |
| ZIP/Postal code |
6700 AA |
| Country |
Netherlands |
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| Platforms (1) |
| GPL11532 |
[HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (24)
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| GSM2330004 |
SubjectID 89, low MC-SFA, after |
| GSM2330005 |
SubjectID 93, low MC-SFA, before |
| GSM2330006 |
SubjectID 93, low MC-SFA, after |
| GSM2330007 |
SubjectID 34, low MC-SFA, before |
| GSM2330008 |
SubjectID 34, low MC-SFA, after |
| GSM2330009 |
SubjectID 63, low MC-SFA, before |
| GSM2330010 |
SubjectID 63, low MC-SFA, after |
| GSM2330011 |
SubjectID 8, low MC-SFA, before |
| GSM2330012 |
SubjectID 8, low MC-SFA, after |
| GSM2330013 |
SubjectID 64, high MC-SFA, before |
| GSM2330014 |
SubjectID 64, high MC-SFA, after |
| GSM2330015 |
SubjectID 65, high MC-SFA, before |
| GSM2330016 |
SubjectID 65, high MC-SFA, after |
| GSM2330017 |
SubjectID 88, high MC-SFA, before |
| GSM2330018 |
SubjectID 88, high MC-SFA, after |
| GSM2330019 |
SubjectID 87, high MC-SFA, before |
| GSM2330020 |
SubjectID 87, high MC-SFA, after |
| GSM2330021 |
SubjectID 96, high MC-SFA, before |
| GSM2330022 |
SubjectID 96, high MC-SFA, after |
| GSM2330023 |
SubjectID 36, high MC-SFA, before |
| GSM2330024 |
SubjectID 36, high MC-SFA, after |
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| Relations |
| BioProject |
PRJNA344580 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE87382_RAW.tar |
104.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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