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| Status |
Public on May 30, 2018 |
| Title |
Gene expression in alveolar macrophages between bleomycin–treated wild-type and S1pr2-/- mice. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We compared mRNA expression in alveolar macrophages between bleomycin–treated wild-type and S1pr2-/- mice, using DNA microarray analysis. In S1pr2-/- macrophages, 398 genes showed decreases to less than 50% of the levels in wild-type macrophages. In contrast, 122 genes showed more than 2.0-fold increases in S1pr2-/- macrophages compared with wild-type macrophages. The downregulated genes in S1pr2-/- mice included the following potentially fibrosis–related genes: profibrotic cytokines, chemokines, and the markers characteristic of classically activated (M1) and alternatively activated (M2) macrophages.
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| Overall design |
BALF cells from wild-type and S1pr2-/- mice on day 22 after bleomycin administration were collected and analyzed. Two independent experiments were performed.
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| Contributor(s) |
Takuwa Y, Okamoto Y |
| Citation(s) |
29782549 |
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| Submission date |
Aug 10, 2016 |
| Last update date |
May 30, 2018 |
| Contact name |
Takumi Nishiuchi |
| E-mail(s) |
[email protected]
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| Organization name |
Kanazawa University
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| Street address |
13-1 Takaramachi
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| City |
Kanazawa |
| ZIP/Postal code |
920-0934 |
| Country |
Japan |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA338392 |
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