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Series GSE8361 Query DataSets for GSE8361
Status Public on Jul 01, 2008
Title Juvenile idiopathic arthritis: peripheral blood cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Systemic-onset juvenile idiopathic arthritis (soJIA) is a rheumatic disease in childhood characterized by systemic symptoms and a relatively poor prognosis. The peripheral leukocytes are thought to play the pathological role of soJIA although the exact cause is still obscure. In this study, we aimed to clarify the cellular functional abnormality in those cells. Here, we analyzed the gene expression profile in peripheral leukocytes from 51 patients with soJIA, 6 patients with poly-articular type JIA (polyJIA) and 8 healthy children utilizing DNA microarrays. A total of 3,491 genes, including genes related to immune reponse and metabolism, were differentially expressed in patients with soJIA compared to healthy individuals. The result provides insight into the pathogenesis of soJIA.
Keywords: disease state analysis
 
Overall design Total RNA was extracted from peripheral leukocytes from 51 soJIA patients, 6 poly-articular type JIA patients, and 8 healthy children. The gene expression profile was analyzed with DNA microarrays.
 
Contributor(s) Ishikawa S, Mima T, Aoki C, Yoshiwo-Hoshino N, Adachi Y, Imagawa T, Mori M, Tomiita M, Iwata N, Murata T, Miyoshi M, Takei S, Aihara Y, Yokota S, Matsubara K, Nishimoto N
Citation(s) 18388159
Submission date Jul 03, 2007
Last update date Mar 17, 2012
Contact name Norihiro Nishimoto
E-mail(s) [email protected]
Phone +81-72-646-8039
Fax +81-72-646-8140
Organization name Wakayama Medical University
Lab Laboratory of Immune Regulation
Street address 7-7-20, Saito-Asagi
City Ibaraki
State/province Osaka
ZIP/Postal code 567-0085
Country Japan
 
Platforms (1)
GPL1291 Hitachisoft AceGene Human Oligo Chip 30K 1 Chip Version
Samples (65)
GSM207108 Peripheral blood cells - healthy child - 1
GSM207109 Peripheral blood cells - healthy child - 2
GSM207110 Peripheral blood cells - healthy child - 3
Relations
BioProject PRJNA101383

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE8361_RAW.tar 339.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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