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| Status |
Public on Mar 24, 2016 |
| Title |
Genome wide comparison of the inducible transcriptomes of CAR, PXR and PPARα in primary human hepatocytes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To identify the CAR-, PXR- and PPARα-specific genome-wide expression changes, hepatocyte cultures from six individual donors were treated with the prototypical ligands for
CAR (CITCO), PXR (rifampicin) and PPARα (WY14,643) as well as DMSO (vehicle control). Afterwards, the mRNA expression in these samples was determined utilizing Affymetrix® microarrays.
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| Overall design |
Primary human hepatocytes (PHH) from 6 donors were treated for 24 h with 10µM of rifampicin, 50µM of WY14,643, 1µM of CITCO and 0.1% of DMSO (vehicle).
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| Contributor(s) |
Kandel BA, Thomas M, Damm G, Winter S, Seehofer D, Burk O, Schwab M, Zanger UM |
| Citation(s) |
26994748 |
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| Submission date |
Dec 18, 2015 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Ulrich M. Zanger |
| E-mail(s) |
[email protected]
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| Organization name |
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
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| Street address |
Auerbachstr. 112
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| City |
Stuttgart |
| ZIP/Postal code |
70376 |
| Country |
Germany |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (24)
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| GSM1975033 |
PHH from Donor 1 (D1), treated with DMSO |
| GSM1975034 |
PHH from Donor 1 (D1), treated with Rifampicin |
| GSM1975035 |
PHH from Donor 1 (D1), treated with CITCO |
| GSM1975036 |
PHH from Donor 1 (D1), treated with WY14,643 |
| GSM1975037 |
PHH from Donor 1 (D2), treated with DMSO |
| GSM1975038 |
PHH from Donor 1 (D2), treated with Rifampicin |
| GSM1975039 |
PHH from Donor 1 (D2), treated with CITCO |
| GSM1975040 |
PHH from Donor 1 (D2), treated with WY14,643 |
| GSM1975041 |
PHH from Donor 1 (D3), treated with DMSO |
| GSM1975042 |
PHH from Donor 1 (D3), treated with Rifampicin |
| GSM1975043 |
PHH from Donor 1 (D3), treated with CITCO |
| GSM1975044 |
PHH from Donor 1 (D3), treated with WY14,643 |
| GSM1975045 |
PHH from Donor 1 (D4), treated with DMSO |
| GSM1975046 |
PHH from Donor 1 (D4), treated with Rifampicin |
| GSM1975047 |
PHH from Donor 1 (D4), treated with CITCO |
| GSM1975048 |
PHH from Donor 1 (D4), treated with WY14,643 |
| GSM1975049 |
PHH from Donor 1 (D5), treated with DMSO |
| GSM1975050 |
PHH from Donor 1 (D5), treated with Rifampicin |
| GSM1975051 |
PHH from Donor 1 (D5), treated with CITCO |
| GSM1975052 |
PHH from Donor 1 (D5), treated with WY14,643 |
| GSM1975053 |
PHH from Donor 1 (D6), treated with DMSO |
| GSM1975054 |
PHH from Donor 1 (D6), treated with Rifampicin |
| GSM1975055 |
PHH from Donor 1 (D6), treated with CITCO |
| GSM1975056 |
PHH from Donor 1 (D6), treated with WY14,643 |
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| Relations |
| BioProject |
PRJNA306430 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE76148_RAW.tar |
99.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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