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| Status |
Public on Dec 12, 2015 |
| Title |
Development of gene expression signatures for knockdown of synthetic lethal gene |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We performed genome-wide expression profiling analysis to define the genes underlying the synthetic-lethal relationship between CBP and p300. We extracted 1,936 genes whose expression levels changed >2-fold upon p300-knockdown (KD) in CBP-KO cells, or upon CBP-KD in p300-KO cells, but not in either KD in wild-type cells
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| Overall design |
Gene expression profile in human lung H1299, H1299 CBP KO, H1299 p300KO cells was measured at 48 hours after transfection of siNT, siCBP or sip300. Two independent experiments were performed at each time (48 hours).
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| Contributor(s) |
Ogiwara H, Kohno T |
| Citation(s) |
26603525 |
| |
| Submission date |
Oct 02, 2015 |
| Last update date |
Nov 27, 2018 |
| Contact name |
Takashi Kohno |
| E-mail(s) |
[email protected]
|
| Phone |
+81-3-3547-2511 (4650)
|
| Organization name |
National Cancer Center Research Institute
|
| Lab |
Division of Genome Biology
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| Street address |
1-1, Tsukiji 5-chome
|
| City |
Chuo-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
104-0045 |
| Country |
Japan |
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| Platforms (1) |
| GPL13607 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version) |
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| Samples (14)
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| Relations |
| BioProject |
PRJNA297663 |
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