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| Status |
Public on Sep 28, 2018 |
| Title |
overexpression/knockdown MEG3 in C2C12 cell lines |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
MEG3 was known as a growth suppressor in tumor cells by activating p53. Besides, MEG3 could regulate transforming growth factor-β (TGF-β) signaling pathway, which is the key regulator of skeletal myogenesis and can enhance the proliferation of myogenic cells. Previous study also showed MEG3 was highly expressed in the paraxial mesoderm and probably regulated muscle development. To investigate the potential function of MEG3 in muscle development, we detected the expression levels of protein-coding genes after MEG3 over-expression or knockdown in C2C12 cell line using microarrays.
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| |
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| Overall design |
Identification of differentially expressed genes in C2C12 cell lines after MEG3 overexpression and knockdown
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| Contributor(s) |
Tang Z, Li K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 28, 2015 |
| Last update date |
Sep 29, 2018 |
| Contact name |
Zhonglin Tang |
| E-mail(s) |
[email protected]
|
| Phone |
+86-10-62813822
|
| Organization name |
Chinese Academy of Agricultural Sciences
|
| Department |
Institute of Animal Science
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| Lab |
Department of Gene and Cell Engineering
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| Street address |
No. 2 Yuanmingyuan West Road, Beijing, 100193, P.R.China,
|
| City |
Beijing |
| ZIP/Postal code |
100193 |
| Country |
China |
| |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA297217 |
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