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| Status |
Public on Sep 11, 2015 |
| Title |
Differential Toxicity of Nuclear RNA Foci Versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Nuclear RNA foci are often associated with mis-regulation of RNA processing in repeat expansion diseases. Here we report transcriptomic analysis of flies carrying expanded G4C2 repeats, the most common genetic cause of FTD/ALS. By obtaining an average of 32 million reads per library, we show that the presence of numerous nuclear G4C2 repeat RNA foci does not cause extensive changes in RNA processing in this model organism.
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| |
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| Overall design |
Comparision of the transcriptomic profile of flies expressing 5R or 160R from two different chromosomes
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| |
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| Contributor(s) |
Tran H, Moore J, Weng Z, Gao F |
| Citation(s) |
26402604 |
| |
| Submission date |
Sep 08, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Fen-Biao Gao |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Massachusetts Medical School
|
| Department |
Department of Neurology
|
| Street address |
55 Lake Avenue North
|
| City |
Worcester |
| State/province |
Massachusetts |
| ZIP/Postal code |
01605 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19132 |
Illumina NextSeq 500 (Drosophila melanogaster) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA295028 |
| SRA |
SRP063448 |
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