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| Status |
Public on Aug 13, 2015 |
| Title |
Interspecies Comparative Genomics Identifies Optimal Mouse Models of Scleroderma (Tsk2) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Systemic sclerosis (SSc) is confounded by considerable disease heterogeneity. Animal models of SSc that recapitulate distinct subsets of disease at the molecular level have not delineated. We applied interspecies comparative analysis of genomic data from multiple mouse models of SSc and patients with SSc to determine which animal models best reflect the SSc intrinsic gene expression subsets.
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| Overall design |
Gene expression measured in skin from mice with sclerodermatous graft-versus-host disease, bleomycin-induced fibrosis, or Tsk1/+ and Tsk2/+ mice was mapped to human orthologs and compared to SSc skin biopsy-derived gene expression.
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| Contributor(s) |
Sargent J, Li Z |
| Citation(s) |
26945694 |
| |
| Submission date |
Aug 12, 2015 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Michael Whitfield |
| Phone |
6036501105
|
| Organization name |
Geisel School of Medicine at Dartmouth
|
| Department |
Genetics
|
| Street address |
710 Remsen 74 College Street
|
| City |
Hanover |
| State/province |
New Hampshire |
| ZIP/Postal code |
03755 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (10)
|
| GSM1849416 |
Tsk2 transgenic 1month old TSK2_1month_10120-1 |
| GSM1849417 |
Tsk2 transgenic 1month old TSK2_1month_10120-1 (rep1) |
| GSM1849418 |
Tsk2 transgenic 1month old TSK2_1month_10120-2 |
| GSM1849419 |
Tsk2 transgenic 1month old TSK2_1month_10121-1 |
| GSM1849420 |
Tsk2 transgenic 1month old TSK2_1month_10121-2 |
| GSM1849421 |
Tsk2 transgenic 4month old TSK2_4month_9869-1 |
| GSM1849422 |
Tsk2 transgenic 4month old TSK2_4month_9919-1 |
| GSM1849423 |
Tsk2 transgenic 4month old TSK2_4month_9919-1 (rep1) |
| GSM1849424 |
Tsk2 transgenic 4month old TSK2_4month_9919-2 |
| GSM1849425 |
Tsk2 transgenic 4month old TSK2_4month_9920-1 |
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| This SubSeries is part of SuperSeries: |
| GSE71999 |
Interspecies Comparative Genomics Identifies Optimal Mouse Models of Scleroderma |
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| Relations |
| BioProject |
PRJNA292692 |
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