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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jun 18, 2015 |
| Title |
Mouse lung tissue transcriptome response to H1N1, H5N1, and mutants [mRNA] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The purpose is to obtain samples for mRNA, miRNA, proteomics, lipidomics, metabolomics, and histopathology analysis in mouse lung infected with WT A/Vietnam/1203/2004 (H5N1; 'VN1203'), VN1203-NS1trunc124, and WT A/California/04/2009 (H1N1; 'CA04').
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| Overall design |
Groups of 22-week-old C57BL/6 mice were infected with WT A/Vietnam/1203/2004 (H5N1; 'VN1203'), VN12013-PB2-627E, VN1203-NS1trunc124, and WT A/California/04/2009 (H1N1; 'CA04').Infections were done at 176 PFU/mouse for VN1203, 1100 PFU/mouse for VN1203-NS1trunc124, and 10^4 PFU/mouse for CA04. Time points were 1, 2, 4, and 7 d.p.i. There were 5 mice for all infection groups and 3 mice for all mock groups. Lung samples were collected for virus load, transcriptional and proteomics analysis. Weight loss and animal survival were also monitored.
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| Contributor(s) |
Stratton K, Waters KM, Eisfeld AJ, Kawaoka Y |
| Citation(s) |
34051754, 38565538 |
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| Submission date |
Jun 17, 2015 |
| Last update date |
Jun 19, 2024 |
| Contact name |
Natalie Heller |
| E-mail(s) |
[email protected]
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| Organization name |
PNNL
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| Street address |
902 Battelle Blvd.
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| City |
Richland |
| ZIP/Postal code |
99354 |
| Country |
USA |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (67)
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| This SubSeries is part of SuperSeries: |
| GSE65575 |
Modeling Host Responses to Understand Severe Human Virus Infections |
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| Relations |
| BioProject |
PRJNA287214 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE69945_RAW.tar |
144.8 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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