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| Status |
Public on Apr 10, 2015 |
| Title |
Role of TBC1D4 in mouse kidneys: Identification of compensatory mechanisms in the DCT of TBC1D4-deficient mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In vitro studies identified TBC1D4 as an regulator of renal ion and water transporting proteins. However, TBC1D4-deficient mice did not show a defective renal salt and water homeostasis.
With microarray analysis we aimed to decipher compensatory mechanisms in TBC1D4-deficient mice which might mask the renal phenotype already on transciptomic levels.
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| Overall design |
We used and compared mRNA of COPAS-sorted and -enriched distal convoluted tubule (DCT)-cells, known to express TBC1D4 at high levels, of 8-week old male homogenous C57/Bl6 mice of TBC1D4-deficient and wild-type mice.
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| Contributor(s) |
Di Chiara M, Loffing J |
| Citation(s) |
26336159 |
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| Submission date |
Apr 09, 2015 |
| Last update date |
Apr 18, 2017 |
| Contact name |
Marianna Di Chiara |
| Organization name |
University of Zurich
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| Department |
Institute of Anatomy
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| Lab |
Prof. Johannes Loffing
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| Street address |
Winterthurerstrasse 190
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| City |
Zurich |
| State/province |
Zurich |
| ZIP/Postal code |
8057 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL11533 |
[MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA280721 |
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