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| Status |
Public on Mar 09, 2015 |
| Title |
Genome-Wide Gene Expression Profiles in the Pancreatic Lymph Nodes of non-obese diabetic (NOD) mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Type 1 diabetes (T1D) is a polygenic autoimmune disorder caused by autoreactive T cells that recognize pancreatic islet antigens and subsequently destroy insulin-producing β-cells. Pancreatic lymph nodes (PLN) are an essential site for the development of T1D, where tolerance to pancreatic self-antigens is first broken and the autoimmune responses are amplified. The purpose of this study was to identify candidate genes and pathways in the PLN that may contribute to the pathogenesis of T1D using a mouse model of T1D.
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| Overall design |
Genome-wide gene expression was measured in individual NOD PLN at 10 days (n=6), 4 weeks (n=6) or 12 weeks of age (n=5), against a pooled sample of age-matched NOD.B10 PLN as the control (n≥6), using Agilent Whole Mouse Genome Microarrays.
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| Contributor(s) |
Kodama K, Yip L, Fuhlbrigge R, Fathman CG |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 09, 2015 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Keiichi Kodama |
| E-mail(s) |
[email protected]
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| Organization name |
Stanford Univeristy School of Medicine
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| Department |
Department of Medicine, Division of Immunology & Rheumatology
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| Lab |
Fathman
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| Street address |
269 Campus Drive, Room 2225
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305-5166 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA277635 |
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