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| Status |
Public on May 01, 2018 |
| Title |
Phenotypic analysis of conventional knockout mice lacking a protein responsible for ossification of the posterior longitudinal ligament |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We found disease-specific proteins from serum proteomics of ossification of posterior longitudinal ligament, and made knockout mice.
We discovered protein peculiar to a disease in serum of the ossification of posterior longitudinal ligament (OPLL), and, as a result of producing knockout mouse, we checked spinal ligament ossification and combination of diabetes and thought that it was a typical mouse and analyzed the sequence of the kidney organization.
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| Overall design |
Proteomics analysis carried out OPLL of the wild mouse that the ossification of the ligament was confirmed when glucose and urine glucose showed a mouse to the high value from a knockout
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| Contributor(s) |
Tsuru M, Nagata K |
| Citation(s) |
29782494 |
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| Submission date |
May 12, 2014 |
| Last update date |
May 25, 2018 |
| Contact name |
Michiyo Tsuru |
| E-mail(s) |
[email protected]
|
| Phone |
81-942-31-7568
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| Organization name |
Kurume Universuty
|
| Department |
Orthopardic Surgery
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| Street address |
67 Asahimachi
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| City |
Kurume |
| State/province |
Fukuoka |
| ZIP/Postal code |
830-0011 |
| Country |
Japan |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA246741 |
