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| Status |
Public on Dec 02, 2013 |
| Title |
Gene expression profiling of MYC-amplified medulloblastoma cell lines treated by JQ1, a BET bromodomain inhibitor |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
MYC-amplified medulloblastomas are highly lethal tumors. BET bromodomain inhibition was recently described to downregulate MYC-associated transcriptional activity in various cancer subtypes. To investigate whether JQ1, a BET bromodomain inhibitor is downregulation MYC and MYC-associated transcriptional activity, we performed global gene expression profiling of five medulloblastomas MYC-amplified patient-derived cell lines treated by JQ1 and the inactive form of JQ1.
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| Overall design |
Five medulloblastomas patient-derived MYC-amplified cell lines were treated with the active and the inactive form of the drug (JQ1S or JQ1R, respectively, 1μM for 24 hours) followed by RNA extraction and hybridization on Affymetrix microarrays
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| Contributor(s) |
Rameen B, Yoon-Jae C |
| Citation(s) |
24297863 |
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| Submission date |
Sep 19, 2013 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Rameen Beroukhim |
| E-mail(s) |
[email protected]
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| Organization name |
DANA-FARBER CANCER INSTITUTE
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| Department |
Cancer Biology
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| Street address |
450 Brookline Av
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (10)
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| GSM1234970 |
MB002 cell line, treated by JQ1 (form active) |
| GSM1234971 |
MB002 cell line, treated by JQ1 (form inactive) |
| GSM1234972 |
MB004 cell line, treated by JQ1 (form active) |
| GSM1234973 |
MB004 cell line, treated by JQ1 (form inactive) |
| GSM1234974 |
D283 cell line, treated by JQ1 (form active) |
| GSM1234975 |
D283 cell line, treated by JQ1 (form inactive) |
| GSM1234976 |
D458 cell line, treated by JQ1 (form active) |
| GSM1234977 |
D458 cell line, treated by JQ1 (form inactive) |
| GSM1234978 |
D556 cell line, treated by JQ1 (form active) |
| GSM1234979 |
D556 cell line, treated by JQ1 (form inactive) |
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| Relations |
| BioProject |
PRJNA219643 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE51020_RAW.tar |
43.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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