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Series GSE48329 Query DataSets for GSE48329
Status Public on Jun 27, 2013
Title Interleukin-17 mediated paracrine network promote tumor resistance to anti-angiogenic therapy
Organism Mus musculus
Experiment type Expression profiling by array
Summary While angiogenesis inhibitors have provided significant clinical benefit as cancer therapeutics, the mechanisms of anti-VEGF resistance remain incompletely understood. We uncovered an interleukin-17 mediated paracrine network of signaling between the adaptive and innate immune system associated with resistance to anti-VEGF treatment in multiple tumor models.
 
Overall design The expression of tumor-associated fibroblasts and tumor-associated granulocytes (defined as CD11b+Gr1+) and tumor-associated monocytic cells (defined as CD11b+Gr1-) were compared between wildtype and IL-17RC knockout tumor bearing mice.
 
Contributor(s) Chung A, Ferrara N, Jiang Z, Modrusan Z
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Submission date Jun 26, 2013
Last update date Jan 12, 2017
Contact name Zhaoshi Jiang
E-mail(s) [email protected]
Phone 6504675508
Organization name Genentech, Inc
Department Bioinformatics
Street address 1 DNA Way
City South San Francisco
State/province CA
ZIP/Postal code 94080
Country USA
 
Platforms (1)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
Samples (20)
GSM1174950 CD11b+Gr1+ cell sample_1 (derived from wild type mouse)
GSM1174951 CD11b+Gr1+ cell sample_2 (derived from wild type mouse)
GSM1174952 CD11b+Gr1+ cell sample_3 (derived from wild type mouse)
Relations
BioProject PRJNA209708

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE48329_RAW.tar 87.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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