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| Status |
Public on Apr 26, 2013 |
| Title |
Investigation of Alterations in Gene Expression in the Retina Induced by High-Affinity Peptides targeting vascular endothelial growth factor, AAP and HAN |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we demonstrate that high-affinity peptides targeting vascular endothelial growth factor, AAP and HAN, suppress in vivo pathologic angiogenesis in the retina. To figure out any definite toxicity at the level of gene expression, we performed microarray analyses of gene expression from retinal tissues after the treatment with AAP and HAN
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| Overall design |
We intravitreally injected PBS, AAP, or HAN into the right eyes of C57BL/6 male mice (n = 12 per group). PBS-treated mice were regarded as negative control. Four retinal tissues were pooled into 1 test tube and prepared for further analyses.
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| Contributor(s) |
Jo D, Jon S, Kim J |
| Citation(s) |
24388818 |
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| Submission date |
Apr 25, 2013 |
| Last update date |
Nov 01, 2017 |
| Contact name |
Jeong Hun Kim |
| Organization name |
Seoul National University
|
| Lab |
FARB (Fight against Angiogenesis-Related Blindness) Laboratory
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| Street address |
101, Daehak-ro, Jongno-gu
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| City |
Seoul |
| ZIP/Postal code |
110744 |
| Country |
South Korea |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA198862 |
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