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| Status |
Public on Apr 16, 2013 |
| Title |
Investigation of Alterations in Gene Expression in the Retina Induced by Intravitreal Injection of SH-42 and SH-80 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we demonstrate that SH-42 and SH-80, novel heat shock protein 90 inhibitors, suppress retinal neovascularization via inhibition of hypoxia-mediated angiogenesis. To figure out any genotoxic effect of these compounds related with heat shock protein 90 inhibition, we performed microarray analyses with retinal tissues treated with SH-42 and SH-80 for 7 days.
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| Overall design |
We intravitreally injected PBS, SH42, or SH80 into the right eyes of C57BL/6 male mice (n = 12 per group). PBS-treated mice were regarded as negative control. Four retinal tissues were pooled into 1 test tube and prepared for further analyses.
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| Contributor(s) |
Jo DH, An H, Cho CS, Jun H, Kim J, Suh Y, Kim J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Apr 15, 2013 |
| Last update date |
Nov 01, 2017 |
| Contact name |
Jeong Hun Kim |
| Organization name |
Seoul National University
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| Lab |
FARB (Fight against Angiogenesis-Related Blindness) Laboratory
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| Street address |
101, Daehak-ro, Jongno-gu
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| City |
Seoul |
| ZIP/Postal code |
110744 |
| Country |
South Korea |
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| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA197139 |
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