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| Status |
Public on Jan 09, 2022 |
| Title |
The Replication Kinase Cdc7 Marks Histones to Regulate Biosynthesis Genes |
| Organism |
Saccharomyces cerevisiae |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We demonstrate that the Cdc7/Dbf4-dependent histone modification, H3 threonine 45 phosphorylation (H3T45p), is specifically enriched at origins of replication, and highly transcribed genes involved in protein synthesis and glycolysis. Furthermore, we show that H3T45p also mediates polymerase recruitment and expression of these genes.
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| Overall design |
Histone H3 threonine 45 phosphorylation mapped in S. cerevisiae using ChIP-seq
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| |
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| Contributor(s) |
Sendinc E, Hoang SA, Xu X, Zakari M, Gerton JL, Bekiranov S, Grant PA |
| Citation missing |
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| |
| Submission date |
Jan 24, 2013 |
| Last update date |
Jan 09, 2022 |
| Contact name |
Stephen Aurelien Hoang |
| Organization name |
HemoShear Therapeutics
|
| Street address |
501 Locust Ave, Suite 301
|
| City |
Charlottesville |
| State/province |
Virginia |
| ZIP/Postal code |
22902 |
| Country |
USA |
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| Platforms (1) |
| GPL9377 |
Illumina Genome Analyzer II (Saccharomyces cerevisiae) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA187389 |
| SRA |
SRP018229 |
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