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| Status |
Public on Dec 31, 2013 |
| Title |
Gene expression changes in Su(H) induced wing disc hyperplasia |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
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| Summary |
The outcome of Notch activation of proliferation depends on cellular context. In Drosophila wing discs Notch pathway overactivation results in hyperplasia. To understand the mechanisms we have used genomic strategies to indetify the Notch-S(H) target genes directly regulated in wing disc hyperplasia. These data are the results from expression profiling the RNAs from hyperplastic wing discs overexpressing Su(H).
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| Overall design |
Direct comparison of Giant third instar lavae wing imaginal disc (UAS-GFP:Su(H) expressed by the patched[559.1]-Gal4 driver) vs control (UAS-NLS-GFP expressed by the patched[559.1]-Gal4 driver). 3 Biological replicates, the 3rd replicate was performed as a dye-swap.
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| Contributor(s) |
Djiane A, Krejci A, Bray SJ |
| Citation(s) |
23232763 |
| |
| Submission date |
Oct 09, 2012 |
| Last update date |
Jun 25, 2014 |
| Contact name |
Sarah Bray |
| E-mail(s) |
[email protected]
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| Organization name |
University of Cambridge
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| Department |
PDN
|
| Street address |
Downing Street
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| City |
Cambridge |
| ZIP/Postal code |
CB2 3DY |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL14121 |
FL003 - INDAC Drosophila melanogaster 14.5K long oligo array (FlyBase r.5.39) |
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| Samples (3) |
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| This SubSeries is part of SuperSeries: |
| GSE41429 |
Notch-regulated genes in wing disc hyperplasia |
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| Relations |
| BioProject |
PRJNA176933 |
